eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| arachnoiditis | ||||
| Disease ID | 926 |
|---|---|
| Disease | arachnoiditis |
| Definition | Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25) |
| Synonym | arachnitis arachnoid membrane inflamm arachnoid membrane inflammation arachnoid membrane inflammations arachnoiditides arachnoiditis (disorder) arachnoiditis [disease/finding] arachnoiditis, nos inflamm arachnoid membrane inflammation, arachnoid membrane inflammations, arachnoid membrane other meningitis nos other meningitis nos &/or arachnoiditis other meningitis nos &/or arachnoiditis (disorder) |
| Orphanet | |
| DOID | |
| UMLS | C0003708 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:11) C0039144 | syringomyelia | 7 C0038013 | ankylosing spondylitis | 2 C0041296 | tuberculosis | 2 C0078981 | arachnoid cyst | 2 C0020255 | hydrocephalus | 2 C0038012 | spondylitis | 2 C0030486 | paraplegia | 1 C0026975 | myelitis | 1 C0078981 | arachnoid cysts | 1 C0392548 | cauda equina syndrome | 1 C0021874 | intracranial abscess | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:15) 361 | AQP4 | 2.186 | DISEASES 100506742 | CASP12 | 2.065 | DISEASES 6354 | CCL7 | 2.039 | DISEASES 9244 | CRLF1 | 2.568 | DISEASES 2919 | CXCL1 | 1.451 | DISEASES 3303 | HSPA1A | 1.87 | DISEASES 3309 | HSPA5 | 1.259 | DISEASES 102723508 | KANTR | 2.659 | DISEASES 4512 | MT-CO1 | 2.112 | DISEASES 4535 | MT-ND1 | 2.685 | DISEASES 5817 | PVR | 1.524 | DISEASES 6164 | RPL34 | 3.349 | DISEASES 6863 | TAC1 | 1.001 | DISEASES 284486 | THEM5 | 3.19 | DISEASES 83857 | TMTC1 | 2.889 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 926 |
|---|---|
| Disease | arachnoiditis |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:15) HP:0002829 | Arthralgia HP:0003401 | Paresthesia HP:0000970 | Anhidrosis HP:0000504 | Abnormality of vision HP:0000763 | Sensory neuropathy HP:0002076 | Migraine HP:0001324 | Muscle weakness HP:0012378 | Fatigue HP:0002839 | Urinary bladder sphincter dysfunction HP:0000365 | Hearing impairment HP:0001265 | Hyporeflexia HP:0001287 | Meningitis HP:0000238 | Hydrocephalus HP:0000360 | Tinnitus HP:0000478 | Abnormality of the eye |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:11) HP:0003396 | Syringomyelia | 7 HP:0100775 | Dural ectasia | 2 HP:0100702 | Arachnoid cyst | 2 HP:0000238 | Nonsyndromal hydrocephalus | 2 HP:0002138 | Subarachnoid hemorrhage | 1 HP:0003287 | Abnormality of mitochondrial metabolism | 1 HP:0012486 | Inflammation of spinal cord | 1 HP:0010550 | Paraplegia | 1 HP:0001287 | Meningitis | 1 HP:0002344 | Progressive neurologic deterioration | 1 HP:0002196 | Myelopathy | 1 |
| Disease ID | 926 |
|---|---|
| Disease | arachnoiditis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:8) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:4) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000504 | Abnormality of vision | MP:0012528 | abnormal zone of polarizing activity morphology | any structural anomaly of the subset of cells found in the posterior mesenchyme region of the vertebrate limb bud; Sonic hedgehog (Shh) produced by ZPA represents the key mediator of the polarizing activity that regulates patterning of the limb along the |
| HP:0001324 | Muscle weakness | MP:0000746 | weakness | state of being infirm or less strong than normal |
| HP:0000478 | Abnormality of the eye | MP:0012069 | abnormal horizontal basal cell of olfactory epithelium morphology | any structural anomaly of the flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells, that lie in contact with the bas |
| HP:0002839 | Urinary bladder sphincter dysfunction | MP:0011874 | enlarged urinary bladder | increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys |
Mapped by homologous gene(Total Items:15) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000504 | Abnormality of vision | MP:0013545 | cleft hard palate | cleft in the anterior portion of the palate consisting of bone and mucous membranes; the hard palate is formed from bony processes of the maxilla, premaxilla and palatine bones |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0000970 | Anhidrosis | MP:0013897 | decreased eyelid cilium number | reduction in the number of the hairs that grow at the edge of the upper or lower eyelid |
| HP:0001265 | Hyporeflexia | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001287 | Meningitis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0000478 | Abnormality of the eye | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000360 | Tinnitus | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0000365 | Hearing impairment | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0000238 | Hydrocephalus | MP:0020080 | increased bone mineralization | increase in the rate at which minerals are deposited into bone |
| HP:0003401 | Paresthesia | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0002839 | Urinary bladder sphincter dysfunction | MP:0012676 | dilated brain ventricles | the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid |
| HP:0002076 | Migraine | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001324 | Muscle weakness | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0012378 | Fatigue | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
| HP:0000763 | Sensory neuropathy | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| Disease ID | 926 |
|---|---|
| Disease | arachnoiditis |
| Case | (Waiting for update.) |