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	adenoid cystic carcinoma

Disease ID	1579
Disease	adenoid cystic carcinoma
Definition	Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Synonym	[m](adenoid cystic carcinoma) or (cylindroid adenocarcinoma) or (cylindroid bronchial adenoma) or (cylindroma nos) [m](adenoid cystic carcinoma) or (cylindroid adenocarcinoma) or (cylindroid bronchial adenoma) or (cylindroma nos) (disorder) [m]adenoid cystic carcinoma [m]cylindroid adenocarcinoma [m]cylindroid bronchial adenoma [m]cylindroma nos adenocarcinoma, cylindroid adenocystic carcinoma adenocystic carcinomas adenoid cystic cancer adenoid cystic carcinoma (morphologic abnormality) adenoid cystic carcinomas bronchial adenoma, cylindroid carcinoma adenoid cystic carcinoma, adenocystic carcinoma, adenoid cystic carcinoma, adenoid cystic [disease/finding] carcinomas, adenocystic carcinomas, adenoid cystic cylindroid adenocarcinoma cylindroid bronchial adenoma cylindroma cylindroma (except cylindroma of skin, m-82000) cylindroma (morphologic abnormality) cylindroma, nos (except cylindroma of skin, m-82000) cylindromas cystic carcinoma, adenoid cystic carcinomas, adenoid
DOID	DOID:4866
UMLS	C0010606
MeSH	D003528
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0153676 \| lung metastasis \| 3 C1857941 \| brooke-spiegler syndrome \| 3 C0001430 \| adenoma \| 2 C0007104 \| carcinoma of the breast \| 1 C0220650 \| brain metastases \| 1 C0334347 \| spiradenomas \| 1 C0036091 \| sialolithiasis \| 1 C0205969 \| thymic carcinoma \| 1 C0040053 \| thrombosis \| 1 C0334347 \| spiradenoma \| 1 C0007137 \| epidermoid carcinoma \| 1 C0153687 \| skin metastases \| 1 C0206694 \| mucoepidermoid carcinoma \| 1 C0026277 \| pleomorphic adenoma \| 1 C0016436 \| folliculitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:99) 5605 \| MAP2K2 \| CTD_human 595 \| CCND1 \| CTD_human 5728 \| PTEN \| CTD_human 8243 \| SMC1A \| CTD_human 284058 \| KANSL1 \| CTD_human 2309 \| FOXO3 \| CTD_human 58508 \| KMT2C \| CTD_human 7157 \| TP53 \| CTD_human 55783 \| CMTR2 \| CTD_human 93986 \| FOXP2 \| CTD_human 81029 \| WNT5B \| CTD_human 9223 \| MAGI1 \| CTD_human 3265 \| HRAS \| CTD_human 8289 \| ARID1A \| CTD_human 29072 \| SETD2 \| CTD_human 1387 \| CREBBP \| CTD_human 259266 \| ASPM \| CTD_human 6659 \| SOX4 \| CTD_human 7994 \| KAT6A \| CTD_human 23135 \| KDM6B \| CTD_human 7403 \| KDM6A \| CTD_human 4851 \| NOTCH1 \| CTD_human 5591 \| PRKDC \| CTD_human 546 \| ATRX \| CTD_human 3691 \| ITGB4 \| CTD_human 64324 \| NSD1 \| CTD_human 472 \| ATM \| CTD_human 2033 \| EP300 \| CTD_human 2195 \| FAT1 \| CTD_human 358 \| AQP1 \| CTD_human 7153 \| TOP2A \| CTD_human 6595 \| SMARCA2 \| CTD_human 5290 \| PIK3CA \| CTD_human 23543 \| RBFOX2 \| CTD_human 1612 \| DAPK1 \| CTD_human 4082 \| MARCKS \| CTD_human 54880 \| BCOR \| CTD_human 10847 \| SRCAP \| CTD_human 6605 \| SMARCE1 \| CTD_human 8823 \| FGF16 \| CTD_human 999 \| CDH1 \| CTD_human 53335 \| BCL11A \| CTD_human 4613 \| MYCN \| CTD_human 63035 \| BCORL1 \| CTD_human 2175 \| FANCA \| CTD_human 182 \| JAG1 \| CTD_human 3852 \| KRT5 \| CTD_human 2982 \| GUCY1A3 \| CTD_human 5834 \| PYGB \| CTD_human 672 \| BRCA1 \| CTD_human 54756 \| IL17RD \| CTD_human 55534 \| MAML3 \| CTD_human 2264 \| FGFR4 \| CTD_human 55294 \| FBXW7 \| CTD_human 3645 \| INSRR \| CTD_human 5174 \| PDZK1 \| CTD_human 84159 \| ARID5B \| CTD_human 57419 \| SLC24A3 \| CTD_human 5176 \| SERPINF1 \| CTD_human 3008 \| HIST1H1E \| CTD_human 23209 \| MLC1 \| CTD_human 1462 \| VCAN \| CTD_human 81831 \| NETO2 \| CTD_human 27255 \| CNTN6 \| CTD_human 2621 \| GAS6 \| CTD_human 2620 \| GAS2 \| CTD_human 9874 \| TLK1 \| CTD_human 23774 \| BRD1 \| CTD_human 2019 \| EN1 \| CTD_human 51514 \| DTL \| CTD_human 51477 \| ISYNA1 \| CTD_human 4602 \| MYB \| CTD_human 9700 \| ESPL1 \| CTD_human 8332 \| HIST1H2AL \| CTD_human 653220 \| XAGE1B \| CTD_human 54441 \| STAG3L1 \| CTD_human 6664 \| SOX11 \| CTD_human 23619 \| ZIM2 \| CTD_human 80303 \| EFHD1 \| CTD_human 27344 \| PCSK1N \| CTD_human 54531 \| MIER2 \| CTD_human 23269 \| MGA \| CTD_human 29128 \| UHRF1 \| CTD_human 3485 \| IGFBP2 \| CTD_human 26292 \| MYCBP \| CTD_human 9863 \| MAGI2 \| CTD_human 50805 \| IRX4 \| CTD_human 6484 \| ST3GAL4 \| CTD_human 4603 \| MYBL1 \| CTD_human 4781 \| NFIB \| CTD_human 6651 \| SON \| CTD_human 51742 \| ARID4B \| CTD_human 51659 \| GINS2 \| CTD_human 23220 \| DTX4 \| CTD_human 10933 \| MORF4L1 \| CTD_human 2011 \| MARK2 \| CTD_human 9454 \| HOMER3 \| CTD_human 3866 \| KRT15 \| CTD_human 221037 \| JMJD1C \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1579
Disease	adenoid cystic carcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:6) HP:0002664 \| Neoplasia \| 7 HP:0030731 \| Carcinoma \| 2 HP:0002835 \| Aspiration \| 2 HP:0003764 \| Naevus \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0002015 \| Swallowing difficulty \| 1

Disease ID	1579
Disease	adenoid cystic carcinoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2248595 \| dedifferentiation C0686619 \| lymph node metastases C0494165 \| liver metastasis C0241426 \| glossopyrosis C0220650 \| brain metastases C0153676 \| pulmonary metastases C0153676 \| lung metastases C0029896 \| ent disease C0024232 \| lymphatic metastasis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C1857941 \| brooke-spiegler syndrome \| 2 C0024232 \| lymphatic metastasis \| 1 C0002793 \| dedifferentiation \| 1 C0220650 \| brain metastases \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121913529	19362042	2678	GGT1	umls:C0010606	BeFree	KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT-GAT transition at codon 12 (Gly12Asp).	0.000271442	2009	KRAS	12	25245350	C	T,G,A
rs121913529	19362042	728441	GGT2	umls:C0010606	BeFree	KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT-GAT transition at codon 12 (Gly12Asp).	0.000271442	2009	KRAS	12	25245350	C	T,G,A
rs121913529	19362042	728226	GGTLC3	umls:C0010606	BeFree	KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT-GAT transition at codon 12 (Gly12Asp).	0.000271442	2009	KRAS	12	25245350	C	T,G,A
rs121913529	19362042	3845	KRAS	umls:C0010606	BeFree	KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT-GAT transition at codon 12 (Gly12Asp).	0.000271442	2009	KRAS	12	25245350	C	T,G,A
rs121913529	19362042	653590	GGTLC5P	umls:C0010606	BeFree	KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT-GAT transition at codon 12 (Gly12Asp).	0.000271442	2009	KRAS	12	25245350	C	T,G,A
rs121913529	19362042	729838	GGTLC4P	umls:C0010606	BeFree	KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT-GAT transition at codon 12 (Gly12Asp).	0.000271442	2009	KRAS	12	25245350	C	T,G,A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1579
Disease	adenoid cystic carcinoma
Case	(Waiting for update.)

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