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	acute t cell leukemia

Disease ID	1443
Disease	acute t cell leukemia
Definition	A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.
Synonym	acute t cell lymphoblastic leukemia acute t cell lymphocytic leukemia acute t-cell leukemia acute t-cell leukemias acute t-cell lymphoblastic leukaemia acute t-cell lymphoblastic leukemia acute t-cell lymphocytic leukemia acute t-lymphocytic leukemia acute t-lymphocytic leukemias cortical t all leukemia, acute t-cell leukemia, acute t-lymphocytic leukemia, lymphoblastic, acute, t cell leukemia, lymphoblastic, acute, t-cell leukemia, lymphocytic, acute t cell leukemia, lymphocytic, acute, t-cell leukemia, t-cell, acute leukemias, acute t-cell leukemias, acute t-lymphocytic lymphoblastic leukemia, acute, t cell lymphoblastic leukemia, acute, t-cell lymphocytic leukemia acute bt lymphocytic leukemia, t cell, acute lymphocytic leukemia, t-cell, acute pre t-all pre-t all precursor t cell lymphoblastic leukemia precursor t cell lymphoblastic leukemia lymphoma precursor t cell lymphoblastic lymphoma precursor t-cell lymphoblastic leukaemia precursor t-cell lymphoblastic leukemia precursor t-cell lymphoblastic leukemia (morphologic abnormality) precursor t-cell lymphoblastic leukemia-lymphoma precursor t-cell lymphoblastic leukemia-lymphoma [disease/finding] precursor t-lymphoblastic leukemia precursor t-lymphoblastic leukemia (t-cell all) pro-t all t acute lymphoblastic leukemia t cell leukemia, acute t lymphocytic leukemia, acute t-cell acute lymphoblastic leukaemia t-cell acute lymphoblastic leukemia t-cell acute lymphoblastic leukemia (disorder) t-cell acute lymphoblastic leukemias t-cell acute lymphocytic leukemia t-cell all t-cell leukemia, acute t-cell leukemias, acute t-cell type acute leukemia t-lymphocytic leukemia, acute t-lymphocytic leukemias, acute
DOID	DOID:5603
UMLS	C1961099
MeSH	D054218
SNOMED-CT	SNOMEDCT_US_2016_09_01:277575008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0023418 \| leukemia \| 3 C0281963 \| red cell aplasia \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0034902 \| pure red cell aplasia \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0442874 \| neuropathy \| 1 C0029443 \| osteomyelitis \| 1 C0004134 \| ataxia \| 1 C0010414 \| cryptococcus neoformans \| 1 C0004135 \| ataxia telangiectasia \| 1 C0029132 \| optic neuropathy \| 1 C0027947 \| neutropenia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:18) 5771 \| PTPN2 \| CTD_human 84295 \| PHF6 \| CTD_human 9429 \| ABCG2 \| CTD_human 8915 \| BCL10 \| CLINVAR 6125 \| RPL5 \| CTD_human 4851 \| NOTCH1 \| CTD_human 4004 \| LMO1 \| CTD_human 4005 \| LMO2 \| CTD_human 581 \| BAX \| CLINVAR 64919 \| BCL11B \| CTD_human 55294 \| FBXW7 \| CTD_human 2475 \| MTOR \| CTD_human 6886 \| TAL1 \| CTD_human 3195 \| TLX1 \| CTD_human 4602 \| MYB \| CTD_human 3575 \| IL7R \| CTD_human 4849 \| CNOT3 \| CTD_human 6134 \| RPL10 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:20) 207 \| AKT1 \| CIPHER 55294 \| FBXW7 \| CIPHER;CTD_human 4851 \| NOTCH1 \| CIPHER;CTD_human 5290 \| PIK3CA \| CIPHER 5728 \| PTEN \| CIPHER 7157 \| TP53 \| CIPHER 4004 \| LMO1 \| CTD_human 4005 \| LMO2 \| CTD_human 6125 \| RPL5 \| CTD_human 6886 \| TAL1 \| CTD_human 3195 \| TLX1 \| CTD_human 3575 \| IL7R \| CTD_human 5771 \| PTPN2 \| CTD_human 4849 \| CNOT3 \| CTD_human 84295 \| PHF6 \| CTD_human 2475 \| MTOR \| CTD_human 9429 \| ABCG2 \| CTD_human 6134 \| RPL10 \| CTD_human 4602 \| MYB \| CTD_human 64919 \| BCL11B \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:52) 238 \| ALK \| 1.061 \| DISEASES 2683 \| B4GALT1 \| 2.151 \| DISEASES 8945 \| BTRC \| 1.762 \| DISEASES 84433 \| CARD11 \| 1.945 \| DISEASES 840 \| CASP7 \| 1.216 \| DISEASES 841 \| CASP8 \| 1.023 \| DISEASES 896 \| CCND3 \| 2.112 \| DISEASES 977 \| CD151 \| 2.743 \| DISEASES 914 \| CD2 \| 1.667 \| DISEASES 921 \| CD5 \| 2.191 \| DISEASES 4267 \| CD99 \| 1.47 \| DISEASES 26586 \| CKAP2 \| 2.389 \| DISEASES 1612 \| DAPK1 \| 1.225 \| DISEASES 1676 \| DFFA \| 1.616 \| DISEASES 1677 \| DFFB \| 2.486 \| DISEASES 56616 \| DIABLO \| 1.094 \| DISEASES 1791 \| DNTT \| 2.002 \| DISEASES 2268 \| FGR \| 1.864 \| DISEASES 81608 \| FIP1L1 \| 1.474 \| DISEASES 2534 \| FYN \| 1.084 \| DISEASES 2959 \| GTF2B \| 2.313 \| DISEASES 3205 \| HOXA9 \| 1.315 \| DISEASES 3292 \| HSD17B1 \| 1.889 \| DISEASES 50615 \| IL21R \| 2.161 \| DISEASES 3725 \| JUN \| 1.818 \| DISEASES 3932 \| LCK \| 1.078 \| DISEASES 8861 \| LDB1 \| 2.282 \| DISEASES 3939 \| LDHA \| 1.082 \| DISEASES 3981 \| LIG4 \| 2.001 \| DISEASES 4004 \| LMO1 \| 3.418 \| DISEASES 8543 \| LMO4 \| 3.332 \| DISEASES 5599 \| MAPK8 \| 1.3 \| DISEASES 10367 \| MICU1 \| 2.19 \| DISEASES 4311 \| MME \| 1.713 \| DISEASES 4602 \| MYB \| 1.172 \| DISEASES 4626 \| MYH8 \| 2.751 \| DISEASES 4772 \| NFATC1 \| 1.134 \| DISEASES 4893 \| NRAS \| 1.542 \| DISEASES 5087 \| PBX1 \| 1.416 \| DISEASES 5154 \| PDGFA \| 1.315 \| DISEASES 5406 \| PNLIP \| 1.142 \| DISEASES 5932 \| RBBP8 \| 2.138 \| DISEASES 253260 \| RICTOR \| 1.558 \| DISEASES 23410 \| SIRT3 \| 1.192 \| DISEASES 23408 \| SIRT5 \| 1.589 \| DISEASES 51548 \| SIRT6 \| 1.406 \| DISEASES 51547 \| SIRT7 \| 1.556 \| DISEASES 347734 \| SLC35B2 \| 1.793 \| DISEASES 6693 \| SPN \| 1.618 \| DISEASES 3195 \| TLX1 \| 4.006 \| DISEASES 10043 \| TOM1 \| 2.919 \| DISEASES 7187 \| TRAF3 \| 1.615 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1443
Disease	acute t cell leukemia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:12) HP:0001909 \| Leukemia \| 3 HP:0001875 \| Neutropenia \| 1 HP:0012531 \| Pain \| 1 HP:0002754 \| Bone infection \| 1 HP:0001251 \| Ataxia \| 1 HP:0012378 \| Fatigue \| 1 HP:0002385 \| Paraparesis \| 1 HP:0000105 \| Renal enlargement \| 1 HP:0001138 \| Damaged optic nerve \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0001945 \| Fever \| 1 HP:0012410 \| Pure red cell aplasia \| 1

Disease ID	1443
Disease	acute t cell leukemia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1805794	25746326	7298	TYMS	umls:C1961099	BeFree	Among the investigated polymorphisms and mutations, NBN Glu185Gln significantly decreased susceptibility to B-cell ALL (p=0.037), while TYMS 3R allele decreased susceptibility to T-cell ALL (p=0.011).	0.000271442	2015	NBN	8	89978251	C	G
rs1805794	25746326	4683	NBN	umls:C1961099	BeFree	Among the investigated polymorphisms and mutations, NBN Glu185Gln significantly decreased susceptibility to B-cell ALL (p=0.037), while TYMS 3R allele decreased susceptibility to T-cell ALL (p=0.011).	0.000271442	2015	NBN	8	89978251	C	G
rs387906351	NA	8915	BCL10	umls:C1961099	CLINVAR	NA	0.120271442	NA	BCL10	1	85270827	-	T
rs398122513	NA	581	BAX	umls:C1961099	CLINVAR	NA	0.120271442	NA	BAX	19	48955799	G	A
rs398122842	NA	581	BAX	umls:C1961099	CLINVAR	NA	0.120271442	NA	BAX	19	48955715	GGGGGGG	-

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1443
Disease	acute t cell leukemia
Case	(Waiting for update.)

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