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	acute monoblastic leukemia

Disease ID	845
Disease	acute monoblastic leukemia
Definition	An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.
Synonym	[m]acute monocytic leukaemia [m]acute monocytic leukaemia (disorder) [m]acute monocytic leukemia acute monoblastic leukaemia acute monoblastic leukemias acute monocytic leukaemia acute monocytic leukaemia, fab m5 acute monocytic leukemia acute monocytic leukemia, fab m5 acute monocytic leukemia, fab m5 (disorder) acute monocytic leukemia, morphology acute monocytic leukemia, morphology (morphologic abnormality) acute monocytic leukemias disorder: acute monocytic leukemia, fab m5 (disorder) fab m5 leukemia monoblastic acute leukemia myeloid acute m 05 leukemia, acute monocytic leukemia, monoblastic, acute leukemia, monocytic, acute leukemia, monocytic, acute [disease/finding] leukemia, myeloid, acute, m5 leukemia, myeloid, schilling type leukemia, myeloid, schilling-type leukemia, schilling-type myeloid leukemias, acute monoblastic leukemias, acute monocytic monoblastic leukemia, acute monoblastic leukemias, acute monocytic leukemia, acute monocytic leukemias, acute myeloid leukemia acute m 05 myeloid leukemia, acute, m5 myeloid leukemia, schilling type myeloid leukemia, schilling-type schilling-type myeloid leukemia
Orphanet	ORPHANET:514
OMIM	OMIM:151380
DOID	DOID:8864
UMLS	C0023465
MeSH	D007948
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0013080 \| trisomy 21 \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0023448 \| lymphocytic leukemia \| 1 C0023470 \| myeloid leukemia \| 1 C0023467 \| acute myeloid leukemia \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0002871 \| anemia \| 1 C0002874 \| aplastic anemia \| 1 C0023418 \| leukemia \| 1 C1261473 \| sarcoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 1788 \| DNMT3A \| CTD_human 4297 \| KMT2A \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:90) 19 \| ABCA1 \| 1.896 \| DISEASES 9619 \| ABCG1 \| 2.131 \| DISEASES 10006 \| ABI1 \| 1.851 \| DISEASES 130013 \| ACMSD \| 2.081 \| DISEASES 834 \| CASP1 \| 2.284 \| DISEASES 6370 \| CCL25 \| 1.515 \| DISEASES 1233 \| CCR4 \| 1.207 \| DISEASES 9332 \| CD163 \| 1.25 \| DISEASES 930 \| CD19 \| 1.449 \| DISEASES 914 \| CD2 \| 1.368 \| DISEASES 146722 \| CD300LF \| 2.477 \| DISEASES 958 \| CD40 \| 1.006 \| DISEASES 960 \| CD44 \| 1.12 \| DISEASES 961 \| CD47 \| 1.647 \| DISEASES 962 \| CD48 \| 1.096 \| DISEASES 942 \| CD86 \| 1.192 \| DISEASES 51652 \| CHMP3 \| 2.975 \| DISEASES 1153 \| CIRBP \| 1.808 \| DISEASES 10987 \| COPS5 \| 1.219 \| DISEASES 1435 \| CSF1 \| 1.013 \| DISEASES 1789 \| DNMT3B \| 1.314 \| DISEASES 84444 \| DOT1L \| 1.287 \| DISEASES 2060 \| EPS15 \| 1.804 \| DISEASES 2113 \| ETS1 \| 2.315 \| DISEASES 2152 \| F3 \| 1.957 \| DISEASES 2209 \| FCGR1A \| 2.593 \| DISEASES 2331 \| FMOD \| 1.229 \| DISEASES 2526 \| FUT4 \| 2.436 \| DISEASES 5348 \| FXYD1 \| 1.142 \| DISEASES 2821 \| GPI \| 1.074 \| DISEASES 2882 \| GPX7 \| 1.905 \| DISEASES 9146 \| HGS \| 1.354 \| DISEASES 8337 \| HIST2H2AA3 \| 1.497 \| DISEASES 8338 \| HIST2H2AC \| 1.497 \| DISEASES 3105 \| HLA-A \| 1.187 \| DISEASES 3106 \| HLA-B \| 1.07 \| DISEASES 3146 \| HMGB1 \| 1.507 \| DISEASES 3201 \| HOXA4 \| 2.057 \| DISEASES 3205 \| HOXA9 \| 1.603 \| DISEASES 3563 \| IL3RA \| 1.811 \| DISEASES 3684 \| ITGAM \| 2.296 \| DISEASES 3720 \| JARID2 \| 2.018 \| DISEASES 23210 \| JMJD6 \| 1.036 \| DISEASES 3725 \| JUN \| 1.103 \| DISEASES 3738 \| KCNA3 \| 1.012 \| DISEASES 3984 \| LIMK1 \| 1.198 \| DISEASES 4018 \| LPA \| 1.094 \| DISEASES 5599 \| MAPK8 \| 1.91 \| DISEASES 10227 \| MFSD10 \| 2.583 \| DISEASES 4300 \| MLLT3 \| 3.652 \| DISEASES 4318 \| MMP9 \| 1.433 \| DISEASES 4602 \| MYB \| 2.005 \| DISEASES 4542 \| MYO1F \| 3.177 \| DISEASES 10499 \| NCOA2 \| 1.117 \| DISEASES 4774 \| NFIA \| 1.917 \| DISEASES 645030 \| NFIA-AS1 \| 3.556 \| DISEASES 114548 \| NLRP3 \| 1.715 \| DISEASES 654364 \| NME1-NME2 \| 2.364 \| DISEASES 4831 \| NME2 \| 1.867 \| DISEASES 4942 \| OAT \| 1.481 \| DISEASES 22953 \| P2RX2 \| 1.65 \| DISEASES 5032 \| P2RY11 \| 1.893 \| DISEASES 5030 \| P2RY4 \| 1.904 \| DISEASES 9141 \| PDCD5 \| 1.669 \| DISEASES 84295 \| PHF6 \| 1.524 \| DISEASES 8301 \| PICALM \| 1.09 \| DISEASES 5625 \| PRODH \| 2.047 \| DISEASES 5710 \| PSMD4 \| 1.853 \| DISEASES 5788 \| PTPRC \| 1.73 \| DISEASES 5795 \| PTPRJ \| 1.547 \| DISEASES 10137 \| RBM12 \| 3.365 \| DISEASES 6144 \| RPL21 \| 2.283 \| DISEASES 79897 \| RPP21 \| 3.152 \| DISEASES 6256 \| RXRA \| 1.038 \| DISEASES 6280 \| S100A9 \| 1.41 \| DISEASES 6401 \| SELE \| 1.936 \| DISEASES 5269 \| SERPINB6 \| 1.193 \| DISEASES 677833 \| SNORA54 \| 2.354 \| DISEASES 153218 \| SPINK13 \| 4.11 \| DISEASES 8115 \| TCL1A \| 1.678 \| DISEASES 54790 \| TET2 \| 1.18 \| DISEASES 7037 \| TFRC \| 1.242 \| DISEASES 7075 \| TIE1 \| 1.213 \| DISEASES 7099 \| TLR4 \| 2.067 \| DISEASES 7124 \| TNF \| 2.982 \| DISEASES 10043 \| TOM1 \| 2.204 \| DISEASES 7161 \| TP73 \| 1.178 \| DISEASES 9322 \| TRIP10 \| 1.834 \| DISEASES 285194 \| TUSC7 \| 2.417 \| DISEASES 8565 \| YARS \| 1.213 \| DISEASES
Locus	(Waiting for update.)

Disease ID	845
Disease	acute monoblastic leukemia
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0004845 \| Acute monoblastic leukemia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:11) HP:0001903 \| Anemia \| 1 HP:0001945 \| Fever \| 1 HP:0001909 \| Leukemia \| 1 HP:0100242 \| Sarcoma \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0100523 \| Hepatic abscess \| 1 HP:0001915 \| Aplastic anemia \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0002170 \| Intracranial hemorrhage \| 1

Disease ID	845
Disease	acute monoblastic leukemia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2205936 \| bacteroides fragilis infection C1090821 \| sepsis C0398623 \| hypercoagulability C0152276 \| chloroma C0152025 \| polyneuropathy C0031117 \| peripheral neuropathy C0023885 \| liver abscesses C0012739 \| disseminated intravascular coagulation
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0023885 \| liver abscesses \| 1 C0948976 \| leukemia cutis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0004845	Acute monocytic leukemia	MP:0004049	increased acute promyelocytic leukemia incidence	higher than normal incidence of cancer characterized by rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0004845	Acute monocytic leukemia	MP:0014130	thymus cysts	presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (H

Disease ID	845
Disease	acute monoblastic leukemia
Case	(Waiting for update.)

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