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	acute liver failure

Disease ID	1014
Disease	acute liver failure
Definition	A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
Synonym	acute failure hepatic acute failure liver acute hepatic failure acute hepatic failure (disorder) alf - acute liver failure failure hepatic acute failure, acute hepatic failure, acute liver fhf - fulminant hepatic failure fulminant hepatic failure fulminant hepatic failure (disorder) fulminant hepatic failures fulminant liver failure fulminant liver failures fulminate liver failure fulminating hepatic failure fulminating hepatic failures fulminating liver failure fulminating liver failures hepatic failure - acute hepatic failure, acute hepatic failure, fulminant hepatic failure, fulminating hepatic failures, fulminant hepatic failures, fulminating hepatic fulminant failure liver acute failure alf liver failure, acute liver failure, acute [disease/finding] liver failure, fulminant liver failure, fulminating liver failures, fulminant liver failures, fulminating
Orphanet	ORPHANET:90062
UMLS	C0162557
MeSH	D017114
SNOMED-CT	SNOMEDCT_US_2016_09_01:197270009;SNOMEDCT_US_2016_09_01:235884008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:80) C0019158 \| hepatitis \| 23 C0019151 \| hepatic encephalopathy \| 22 C0019163 \| hepatitis b \| 8 C0023890 \| cirrhosis \| 6 C0085293 \| hepatitis e \| 6 C1527311 \| brain edema \| 5 C0023895 \| liver disease \| 4 C0042721 \| viral hepatitis \| 4 C0019147 \| hepatic coma \| 4 C0019196 \| hepatitis c \| 3 C0001125 \| lactic acidosis \| 3 C0002871 \| anemia \| 3 C0042769 \| virus infection \| 3 C0019202 \| wilson disease \| 3 C0024299 \| lymphoma \| 2 C0019204 \| hepatocellular carcinoma \| 2 C0019100 \| dengue haemorrhagic fever \| 2 C0040127 \| thyroid storm \| 2 C0268542 \| ornithine transcarbamylase deficiency \| 2 C0021345 \| mononucleosis \| 1 C0023891 \| alcoholic liver cirrhosis \| 1 C0023448 \| lymphocytic leukemia \| 1 C0009492 \| compartment syndrome \| 1 C0085273 \| parvovirus b19 infection \| 1 C0001623 \| adrenal insufficiency \| 1 C0020538 \| hypertension \| 1 C0079774 \| peripheral t-cell lymphoma \| 1 C0032285 \| pneumonia \| 1 C0015230 \| rash \| 1 C0019212 \| hepatorenal syndrome \| 1 C0011848 \| diabetes insipidus \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0019829 \| hodgkin's disease \| 1 C0002726 \| amyloidosis \| 1 C0019163 \| hepatitis b infection \| 1 C0151740 \| elevated intracranial pressure \| 1 C0027708 \| wilms tumor \| 1 C0002874 \| aplastic anemia \| 1 C0002895 \| sickle cell anemia \| 1 C0019829 \| hodgkin lymphoma \| 1 C0023890 \| liver cirrhosis \| 1 C0013990 \| emphysema \| 1 C0035920 \| rubella \| 1 C0282193 \| iron overload \| 1 C0023467 \| acute myeloid leukemia \| 1 C0034902 \| pure red cell aplasia \| 1 C0410528 \| skeletal dysplasia \| 1 C0042769 \| viral infection \| 1 C0023895 \| hepatocellular disease \| 1 C0042721 \| virus hepatitis \| 1 C0038041 \| spotted fever \| 1 C0023418 \| leukemia \| 1 C0036472 \| scrub typhus \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0023895 \| liver diseases \| 1 C0006413 \| burkitt lymphoma \| 1 C0041296 \| tuberculosis \| 1 C0021053 \| immune disease \| 1 C0040156 \| thyrotoxicosis \| 1 C0023895 \| liver disorder \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0011847 \| diabetes \| 1 C0018801 \| heart failure \| 1 C0334277 \| metastatic adenocarcinoma \| 1 C1565489 \| renal insufficiency \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0020550 \| hyperthyroidism \| 1 C0687720 \| neurogenic diabetes insipidus \| 1 C0006142 \| breast cancer \| 1 C0023895 \| liver disorders \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0041471 \| typhus \| 1 C0042384 \| vasculitis \| 1 C0023364 \| leptospirosis \| 1 C0879615 \| stromal tumor \| 1 C0281963 \| red cell aplasia \| 1 C0151295 \| mononeuritis multiplex \| 1 C0021345 \| infectious mononucleosis \| 1 C0018801 \| cardiac failure \| 1 C0878544 \| cardiomyopathy \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:22) 10457 \| GPNMB \| CTD_human 3630 \| INS \| CTD_human 213 \| ALB \| CTD_human 3875 \| KRT18 \| CTD_human 7124 \| TNF \| CTD_human 10468 \| FST \| CTD_human 1440 \| CSF3 \| CTD_human 5443 \| POMC \| CTD_human 540 \| ATP7B \| CTD_human 831 \| CAST \| CTD_human 3082 \| HGF \| CTD_human 2671 \| GFER \| CTD_human 6341 \| SCO1 \| CTD_human 356 \| FASLG \| CTD_human 2638 \| GC \| CTD_human 3557 \| IL1RN \| CTD_human 355 \| FAS \| CTD_human 972 \| CD74 \| CTD_human 3624 \| INHBA \| CTD_human 5599 \| MAPK8 \| CTD_human 462 \| SERPINC1 \| CTD_human 3856 \| KRT8 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:22) 7124 \| TNF \| CIPHER;CTD_human 10457 \| GPNMB \| CTD_human 3875 \| KRT18 \| CTD_human 10468 \| FST \| CTD_human 540 \| ATP7B \| CTD_human 2671 \| GFER \| CTD_human 2638 \| GC \| CTD_human 356 \| FASLG \| CTD_human 972 \| CD74 \| CTD_human 3624 \| INHBA \| CTD_human 5599 \| MAPK8 \| CTD_human 355 \| FAS \| CTD_human 3082 \| HGF \| CTD_human 1440 \| CSF3 \| CTD_human 3630 \| INS \| CTD_human 831 \| CAST \| CTD_human 3856 \| KRT8 \| CTD_human 5443 \| POMC \| CTD_human 6341 \| SCO1 \| CTD_human 213 \| ALB \| CTD_human 462 \| SERPINC1 \| CTD_human 3557 \| IL1RN \| CTD_human
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1014
Disease	acute liver failure
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:68) HP:0001298 \| Encephalopathy \| 27 HP:0012115 \| Liver inflammation \| 25 HP:0002480 \| Hepatic encephalopathy \| 22 HP:0000969 \| Dropsy \| 11 HP:0002181 \| Cerebral edema \| 10 HP:0003256 \| Coagulopathy \| 8 HP:0001394 \| Hepatic cirrhosis \| 7 HP:0001259 \| Coma \| 6 HP:0001399 \| Liver failure \| 5 HP:0006562 \| Viral hepatitis \| 4 HP:0200123 \| Chronic liver inflammation \| 4 HP:0001919 \| Acute renal failure \| 4 HP:0200119 \| Acute liver inflammation \| 3 HP:0001903 \| Anemia \| 3 HP:0002045 \| Abnormally low body temperature \| 3 HP:0003128 \| Lactic acidosis \| 3 HP:0002605 \| Hepatic necrosis \| 2 HP:0100806 \| Sepsis \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0001945 \| Fever \| 2 HP:0002665 \| Lymphoma \| 2 HP:0001402 \| Hepatocellular carcinoma \| 2 HP:0200084 \| Giant cell hepatitis \| 2 HP:0001928 \| Abnormal blood coagulation studies \| 2 HP:0001987 \| Hyperammonemia \| 2 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0001250 \| Seizures \| 1 HP:0001909 \| Leukemia \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0040187 \| Neonatal sepsis \| 1 HP:0002090 \| Pneumonia \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0030080 \| Burkitt lymphoma \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0004947 \| Arteriovenous fistula \| 1 HP:0002652 \| Skeletal dysplasia \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0012378 \| Fatigue \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0012531 \| Pain \| 1 HP:0012410 \| Pure red cell aplasia \| 1 HP:0002633 \| Vasculitis \| 1 HP:0002148 \| Hypophosphataemia \| 1 HP:0004900 \| Severe lactic acidosis \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0011029 \| Internal bleeding \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0002664 \| Neoplasia \| 1 HP:0001397 \| Hepatic steatosis \| 1 HP:0000822 \| Hypertension \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001915 \| Aplastic anemia \| 1 HP:0030731 \| Carcinoma \| 1 HP:0000836 \| Overactive thyroid \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0001941 \| acidemia \| 1 HP:0002667 \| Wilms tumor \| 1

Disease ID	1014
Disease	acute liver failure
Manually Symptom	UMLS \| Name(Total Manually Symptoms:38) C2364324 \| increased intracranial pressure C2364050 \| hypothermia C1963154 \| renal failure C1963101 \| encephalopathy C1527311 \| brain swelling C1527311 \| brain edema C1412689 \| wilson disease C1318485 \| liver regeneration C1145670 \| respiratory failure C0948600 \| organ failure C0796095 \| c syndrome C0586989 \| varicella-zoster virus infection C0333980 \| focal nodular hyperplasia C0302809 \| fulminant hepatitis C0242966 \| systemic inflammatory response syndrome (sirs) C0242966 \| systemic inflammatory response syndrome C0235031 \| neurological symptoms C0221773 \| hyperamylasemia C0151740 \| raised intracranial pressure C0151740 \| intracranial hypertension C0042769 \| virus infection C0026946 \| fungal infection C0025517 \| metabolism disorders C0022660 \| acute renal failure C0020541 \| portal hypertension C0019270 \| herniation C0019202 \| wilson's disease C0019163 \| hepatitis b infection C0019151 \| hepatic encephalopathy C0011860 \| diabetes C0005779 \| coagulopathy C0005779 \| coagulation disorders C0005779 \| coagulation defects C0005779 \| blood coagulation disorders C0005699 \| blast crisis C0004623 \| bacterial infections C0004623 \| bacterial infection C0004610 \| bacteremia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:14) C0085584 \| encephalopathy \| 25 C0019151 \| hepatic encephalopathy \| 20 C1527311 \| brain edema \| 6 C0005779 \| coagulopathy \| 6 C0019158 \| hepatitis \| 4 C0020672 \| hypothermia \| 3 C0948600 \| organ failure \| 3 C0019202 \| wilson disease \| 3 C0009450 \| infection \| 2 C0042769 \| virus infection \| 2 C0019270 \| herniation \| 1 C0020649 \| hypotension \| 1 C0011847 \| diabetes \| 1 C0023907 \| liver regeneration \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs8330	23408116	54658	UGT1A1	umls:C0162557	BeFree	The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure.	0.000271442	2013	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3	2	233772999	G	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1014
Disease	acute liver failure
Case	(Waiting for update.)

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