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	acute articular rheumatism

Disease ID	858
Disease	acute articular rheumatism
Definition	A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.
Synonym	active rheumatic fever active rheumatic fever (disorder) acute articular rheumatisms acute rheumatic arthritides acute rheumatic arthritis acute rheumatic arthritis (disorder) acute rheumatic attack acute rheumatic fever acute rheumatic fever (disorder) acute rheumatic fever nos acute rheumatic fever nos (disorder) acute rheumatic fevers acute rheumatism arf - acute rheumatic fever arthritides, acute rheumatic arthritis, acute rheumatic arthritis, rheumatic, acute articular rheumatism, acute articular rheumatisms, acute fever, acute rheumatic fever, rheumatic fevers, acute rheumatic fevers, rheumatic polyarthritis rheumatica polyarthritis rheumaticas rheumatic arthritides, acute rheumatic arthritis rheumatic arthritis acute rheumatic arthritis, acute rheumatic fever rheumatic fever (disorder) rheumatic fever [disease/finding] rheumatic fever, active rheumatic fever, acute rheumatic fever, nos rheumatic fevers rheumatic fevers, acute rheumatism acute rheumatism, acute articular rheumatism, articular, acute rheumatism, inflammatory rheumatisms, acute articular rhf - rheumatic fever
Orphanet	ORPHANET:3099
DOID	DOID:1586
UMLS	C0035436
MeSH	D012213
SNOMED-CT	SNOMEDCT_US_2016_09_01:26424001;SNOMEDCT_US_2016_09_01:81077008;SNOMEDCT_US_2016_09_01:58718002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:25) C0035439 \| rheumatic heart disease \| 4 C0018799 \| heart disease \| 4 C0026269 \| mitral stenosis \| 3 C0003864 \| arthritis \| 2 C0085278 \| antiphospholipid syndrome \| 2 C0017658 \| glomerulonephritis \| 2 C0022116 \| ischaemia \| 1 C0403414 \| acute post-streptococcal glomerulonephritis \| 1 C0036689 \| streptococcal pharyngitis \| 1 C0003507 \| aortic stenosis \| 1 C0264766 \| rheumatic mitral stenosis \| 1 C0403414 \| post-streptococcal glomerulonephritis \| 1 C0004352 \| autism \| 1 C0027059 \| myocarditis \| 1 C0020538 \| hypertension \| 1 C0014070 \| encephalomyelitis \| 1 C0152113 \| sydenham's chorea \| 1 C0018824 \| cardiac valvular disease \| 1 C0020542 \| pulmonary hypertension \| 1 C0014059 \| acute disseminated encephalomyelitis \| 1 C0042769 \| viral infection \| 1 C0031099 \| periodontitis \| 1 C0042769 \| viral infections \| 1 C0031350 \| pharyngitis \| 1 C0242429 \| sore throat \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 2212 \| FCGR2A \| CIPHER 2215 \| FCGR3B \| CIPHER 3117 \| HLA-DQA1 \| CIPHER 3119 \| HLA-DQB1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 7097 \| TLR2 \| CIPHER 7124 \| TNF \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:59) 94 \| ACVRL1 \| 1.386 \| DISEASES 8227 \| AKAP17A \| 4.023 \| DISEASES 250 \| ALPP \| 1.401 \| DISEASES 9179 \| AP4M1 \| 2.262 \| DISEASES 415 \| ARSE \| 1.118 \| DISEASES 721 \| C4B \| 1.33 \| DISEASES 930 \| CD19 \| 1.525 \| DISEASES 959 \| CD40LG \| 3.478 \| DISEASES 926 \| CD8B \| 1.451 \| DISEASES 1029 \| CDKN2A \| 3.374 \| DISEASES 78989 \| COLEC11 \| 2.628 \| DISEASES 27042 \| DIEXF \| 2.848 \| DISEASES 29102 \| DROSHA \| 1.075 \| DISEASES 6993 \| DYNLT1 \| 1.365 \| DISEASES 1908 \| EDN3 \| 1.508 \| DISEASES 55763 \| EXOC1 \| 2.421 \| DISEASES 2152 \| F3 \| 1.111 \| DISEASES 2219 \| FCN1 \| 2.816 \| DISEASES 2638 \| GC \| 1.356 \| DISEASES 51218 \| GLRX5 \| 2.009 \| DISEASES 3105 \| HLA-A \| 2.026 \| DISEASES 3106 \| HLA-B \| 1.128 \| DISEASES 3117 \| HLA-DQA1 \| 1.798 \| DISEASES 3119 \| HLA-DQB1 \| 1.283 \| DISEASES 3120 \| HLA-DQB2 \| 1.397 \| DISEASES 3123 \| HLA-DRB1 \| 1.745 \| DISEASES 3240 \| HP \| 2.465 \| DISEASES 3329 \| HSPD1 \| 1.084 \| DISEASES 219844 \| HYLS1 \| 1.163 \| DISEASES 3586 \| IL10 \| 1.4 \| DISEASES 3559 \| IL2RA \| 1.154 \| DISEASES 10989 \| IMMT \| 1.214 \| DISEASES 55683 \| KANSL3 \| 2.007 \| DISEASES 3778 \| KCNMA1 \| 2.64 \| DISEASES 284217 \| LAMA1 \| 1.913 \| DISEASES 10747 \| MASP2 \| 3.33 \| DISEASES 4153 \| MBL2 \| 2.346 \| DISEASES 56955 \| MEPE \| 1.293 \| DISEASES 57591 \| MKL1 \| 1.204 \| DISEASES 4312 \| MMP1 \| 1.052 \| DISEASES 64359 \| NXN \| 2.067 \| DISEASES 11331 \| PHB2 \| 2.795 \| DISEASES 55660 \| PRPF40A \| 2.272 \| DISEASES 6005 \| RHAG \| 1.021 \| DISEASES 80196 \| RNF34 \| 1.785 \| DISEASES 6227 \| RPS21 \| 2.221 \| DISEASES 6234 \| RPS28 \| 2.726 \| DISEASES 348235 \| SKA2 \| 3.473 \| DISEASES 83733 \| SLC25A18 \| 2.744 \| DISEASES 23443 \| SLC35A3 \| 2.277 \| DISEASES 6651 \| SON \| 2.287 \| DISEASES 8801 \| SUCLG2 \| 2.17 \| DISEASES 26136 \| TES \| 1.972 \| DISEASES 7124 \| TNF \| 2.244 \| DISEASES 8718 \| TNFRSF25 \| 1.189 \| DISEASES 7137 \| TNNI3 \| 2.321 \| DISEASES 7139 \| TNNT2 \| 1.669 \| DISEASES 23660 \| ZKSCAN5 \| 3.439 \| DISEASES 100128252 \| ZNF667-AS1 \| 1.726 \| DISEASES
Locus	(Waiting for update.)

Disease ID	858
Disease	acute articular rheumatism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:20) HP:0001718 \| Mitral stenosis \| 3 HP:0000822 \| Hypertension \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0001369 \| Arthritis \| 2 HP:0012531 \| Pain \| 2 HP:0001701 \| Pericarditis \| 1 HP:0001650 \| Valvular aortic stenosis \| 1 HP:0002072 \| Chorea \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0012722 \| Heart block \| 1 HP:0000717 \| Autism \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0100584 \| Endocarditis \| 1 HP:0001709 \| Complete heart block \| 1 HP:0000707 \| Neurological abnormality \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0200025 \| Mandibular pain \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0012819 \| Myocarditis \| 1

Disease ID	858
Disease	acute articular rheumatism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:4) C2707258 \| infections C2364133 \| infection C1963101 \| encephalopathy C0038325 \| stevens-johnson syndrome
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0869523 \| carditis \| 7 C0009450 \| infection \| 4 C0018799 \| heart disease \| 2 C0003864 \| arthritis \| 2 C0042769 \| viral infection \| 1 C0752303 \| urological manifestation \| 1 C0038395 \| streptococcal infections \| 1 C0027059 \| myocarditis \| 1 C0008489 \| chorea \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs5743708	15968536	7097	TLR2	umls:C0035436	BeFree	TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children.	0.005634266	2005	TLR2	4	153705165	G	A
rs5743708	19693643	7097	TLR2	umls:C0035436	BeFree	Toll-like receptor 2 (TLR2) has been known to recognize several microbial antigens including that of streptococci, and TLR2 gene Arg753Gln polymorphism has been reported to be strongly associated with acute rheumatic fever with an odds ratio of 100.	0.005634266	2009	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	858
Disease	acute articular rheumatism
Case	(Waiting for update.)

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