PedAM
Pediatric Disease Annotations & Medicines
| Disease | proteinuria |
| Phenotype | C0022658|nephropathy |
| Sentences | 71 |
| PubMedID- 22218118 | Renoprotective effects of angiotensin receptor blockers and nac in preventing or reducing of proteinuria in patients with diabetic nephropathy was studied. |
| PubMedID- PMC3991017 | However, it has not been reported in non-diabetic ckd and its role in residual proteinuria in patients with membranous nephropathy is unclear. |
| PubMedID- 24159603 | Advanced diabetic nephropathy with nephrotic range proteinuria: a pilot study of the long-term efficacy of subcutaneous acth gel on proteinuria, progression of ckd, and urinary levels of vegf and mcp-1. |
| PubMedID- 23814426 | [1] proteinuria is usually associated with membranous nephropathy, and it is rarely associated with minimal change disease or mesangioproliferative glomerulonephritis. |
| PubMedID- 21311715 | These observations may provide a mechanistic context to the known protective roles of pparα/γ in kidney diseases, such as diabetic nephropathy, which is associated with proteinuria and compromised expression of megalin. |
| PubMedID- 25476525 | Methods: we performed a genome-wide association study using 1000 genomes-based imputation to compare type 1 diabetic nephropathy cases with proteinuria and with or without renal failure with control patients who have had diabetes for more than 15 years and no evidence of renal disease. |
| PubMedID- 21533280 | Background: studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with immunoglobulin a nephropathy, but the overall benefit of steroids in the treatment of immunoglobulin a nephropathy remains controversial. |
| PubMedID- 24174881 | Acthar® gel (acthar; questcor pharmaceuticals, inc., union city, ca, usa) has recently been shown to induce remission, defined as stabilization or improvement of renal function (by estimated glomerular filtration rate) and resolution of proteinuria, in patients with idiopathic membranous nephropathy.7 herein, we describe a case in which 13 months of treatment with acthar resulted in a sustained remission of membranous nephropathy in a patient with refractory disease. |
| PubMedID- 25621126 | In human diabetic nephropathy with proteinuria, sirt1 was downregulated and claudin1 was upregulated. |
| PubMedID- 21127830 | To be included, all cases in the report had to have diabetes mellitus with macroalbuminuria and/or overt proteinuria, esrd attributed to diabetic nephropathy or biopsy-proven diabetic nephropathy. |
| PubMedID- 26068660 | Initial clinical trials show promise with regard to era effects on reducing proteinuria in patients with diabetic nephropathy (dn) who are already on renin-angiotensin system (ras) blocking agents. |
| PubMedID- 24851611 | The aim of this retrospective cohort study was to assess the risk of developing endemic nephropathy in subjects with proteinuria from the endemic region in croatia. |
| PubMedID- 23557791 | Aims: both steroid pulse (sp) monotherapy and the combination of tonsillectomy and sp therapy (tsp) are effective for achieving clinical remission (cr), defined as negative hematuria and proteinuria, in patients with iga nephropathy (igan). |
| PubMedID- 20682692 | Multiple clinical trials have shown that blockade of the renin-angiotensin system (ras) can improve renal function in late diabetic nephropathy in patients with proteinuria, diabetes, and reduced glomerular filtration rate (2–4). |
| PubMedID- 23197956 | Successful treatment of adult iga nephropathy with nephrotic-level proteinuria by combination therapy including long-term coadministration of mizoribine. |
| PubMedID- 23380390 | Igm nephropathy presenting with proteinuria, especially nephrotic syndrome, frequently is steroid-dependent or steroidresistant and associated with reaching endstage renal disease after a 15-year follow-up. |
| PubMedID- 23815417 | Background: idiopathic membranous nephropathy (imn) patients with persistent high-grade proteinuria are at the highest risk for developing end-stage renal failure. |
| PubMedID- 26558120 | He also had prior nephrotic range proteinuria documented with secondary membranous nephropathy of unspecified etiology. |
| PubMedID- 23977072 | A report from a study carried out in china stated that, among iga nephropathy patients with proteinuria of <0.4 g/day, gfr ≥90 ml/min/1.73 m2, and normotension, proteinuria increased in 46% of patients, hypertension was developed in 38%, and renal insufficiency in 24% during the mean follow-up duration of 111 months [13]. |
| PubMedID- 26300986 | Therefore, we investigated whether pentoxifylline could reduce proteinuria in patients with diabetic nephropathy and residual proteinuria despite receiving an acei or arb. |
| PubMedID- 23326865 | In two small studies, the addition of aliskiren to arb was shown to decrease proteinuria in subjects with iga nephropathy and various forms of primary glomerulonephritis [13, 14]. |
| PubMedID- 25922592 | Available evidences indicate that ptx may decrease proteinuria in patients with diabetic nephropathy [30]. |
| PubMedID- 22291770 | All diabetic patients had normal creatinine; however, seven had evidence of nephropathy (three with frank proteinuria and four with microalbuminuria), and one patient also had pre-proliferative retinopathy. |
| PubMedID- 23404305 | Finally, we defined overt nephropathy as the presence of persistent proteinuria, since an elevated urinary albumin excretion due to nondiabetic renal lesions or conditions is not rare. |
| PubMedID- 23049672 | Oral calcitriol treatment reduced proteinuria in patients with iga nephropathy [172]. |
| PubMedID- 24282787 | C1q nephropathy usually presents with proteinuria or full-blown nephrotic syndrome. |
| PubMedID- 23560927 | In addition astragalus membranaceus has been shown to improve patients’ proteinuria with idiopathic membranous nephropathy [13,14]. |
| PubMedID- 22707888 | Although a metaanalysis showed that pde inhibitor reduces proteinuria in patients with diabetic nephropathy, ptx has not been used in patients with diabetic nephropathy [30]. |
| PubMedID- 22086123 | Reported on the natural history of mild or early-stage iga nephropathy in patients with proteinuria <0.4 g/day over an observation period of 7 years [5]. |
| PubMedID- 24273653 | There have been reports of mmp inhibitors, specifically doxycycline, successfully reducing proteinuria in patients with diabetic nephropathy (aggarwal et al. |
| PubMedID- 20594038 | The authors measured the extent of foot process effacement in 100 iga nephropathy cases with proteinuria and correlated it with the amount of proteinuria. |
| PubMedID- 24707402 | Before the eradication therapy the mean proteinuria of patients with mn, iga nephropathy and fsgs were 2.42 ± 3.24 g/day, 2.12 ± 1.63 g/day and 1.80 ± 1.32 g/day, respectively. |
| PubMedID- 23074118 | A recent study also demonstrated that prevention of glomerular hypertrophy ameliorates the development of diabetic nephropathy, including proteinuria and podocytopenia.26 taken together, the anti-inflammatory, anti-fibrotic, and anti-hypertrophic effects of gla in diabetic nephropathy may be partly attributable to the suppression of mcp-1 and icam-1 expression by gla, by which inflammatory cell infiltration is abrogated, in turn ameliorating ecm accumulation. |
| PubMedID- 23355027 | Conclusions: higher systolic blood pressure, serum phosphorus, and triglyceride levels are associated with nephrotic-range proteinuria in patients with diabetic nephropathy and ckd stage 3-5. |
| PubMedID- 20203469 | Review of the amadeo study: reducing proteinuria in patients with diabetic nephropathy with telmisartan versus losartan. |
| PubMedID- 25447989 | Based on these findings, dual raas blockade is no longer recommended for the routine treatment of various cardiovascular diseases, except diabetic nephropathy with proteinuria and hf with reduced ejection fraction. |
| PubMedID- 20954132 | Conclusion: sirolimus aggravates proteinuria in rats with protein overload nephropathy by damaging podocytes, a barrier of glomerular filtration. |
| PubMedID- 23434935 | Activation of protein kinase c (pkc) has been implicated in the pathogenesis of diabetic nephropathy with proteinuria and peritubular extracellular matrix production. |
| PubMedID- 20799970 | A more accurate evaluation of different aspects of scd nephropathy, emphasizing proteinuria and hyperfiltration, needs to be developed in children in order to detect early renal alteration [14-16]. |
| PubMedID- 21894005 | Although several eras were found to reduce proteinuria in patients with nephropathy, clinical testing was stopped for all but one drug. |
| PubMedID- 26089878 | We conducted a randomized, double-blind, placebo-controlled study of dong-a university nephrology outpatients between june 2009 and october 2010. nineteen diabetic nephropathy patients, with a proteinuria level > 0.3 g/day and undergoing treatment with acei or arb for at least 6 months, were included. |
| PubMedID- 22126210 | Large clinical trials, such as the renaal study, have revealed that losartan exhibits renoprotective effects and inhibits overall mortality in type 2 diabetic nephropathy patients with overt proteinuria [112]. |
| PubMedID- 24317123 | In this study, patient with minimal change nephrotic syndrome and membranous nephropathy had lower levels of mcp-1 suggesting that proteinuria in and of itself was not associated with increased urinary mcp-1 levels and that activation of resident tubular or endothelial cells and interstitial infiltrates is needed for mcp-1 expression (29). |
| PubMedID- 22456060 | Some iga nephropathy (igan) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy with renin- angiotensin system blockade. |
| PubMedID- 23543049 | Methods: we genotyped 3 snps, rs7583877 in aff3, rs12437854 in the rgma-mctp2 locus and rs7588550 in erbb4, for 2,300 japanese patients with type 2 diabetes [initial study, 1,055 nephropathy cases with overt proteinuria or with end-stage renal disease (esrd) and 1,245 control patients with normoalbuminuria]. |
| PubMedID- 20110666 | The tg ren2 rat develops nephropathy with proteinuria, increased renal angiotensin ii levels and oxidative stress, and ptc remodeling. |
| PubMedID- 22759247 | In a recent study high dose cholecalciferol, showed a reduction in proteinuria in patients with diabetic nephropathy on ras blockade [42]. |
| PubMedID- 22865594 | Fk506 alleviates proteinuria in rats with adriamycin-induced nephropathy by down-regulating trpc6 and can expression. |
| PubMedID- 26239461 | The severity of chronic lesions in diabetic nephropathy roughly correlates with degree of proteinuria and renal functional impairment. |
| PubMedID- 23843814 | Diabetic nephropathy with proteinuria, including albuminurinuria, occurs in about 20 – 40 % of diabetics from which a considerable cases may proceed to severe renal failure (2, 3)and also to cardiovascular diseases (4-6). |
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