PedAM
Pediatric Disease Annotations & Medicines
| Disease | arteriosclerosis |
| Phenotype | |diabetes |
| Sentences | 200 |
| PubMedID- 20357380 | diabetes is associated with accelerated atherosclerosis and an increased risk of cardiovascular disease (cvd), which has become the major cause of morbidity and mortality among patients with diabetic nephropathy (1). |
| PubMedID- 25317245 | Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus (dm), with carotid atherosclerosis (ca) being a common risk-factor for prospective crisis of coronary artery diseases (cad) and/or cerebral infarction (ci) in dm subjects. |
| PubMedID- 24392103 | While pwv is affected by changes in instantaneous blood pressure, the cardio-ankle vascular index (cavi) is a blood pressure-independent index of systemic arterial stiffness, and is often used as a marker of early arteriosclerosis associated with hypertension, diabetes mellitus, dyslipidemia and smoking [5]. |
| PubMedID- 26069232 | Little data exist about the relationship of apoc-iii, triglycerides, and atherosclerosis in patients with type 2 diabetes mellitus (t2dm). |
| PubMedID- 24334868 | Background: to our knowledge there has been no study investigating the impact of freeze-dried strawberry (fds) supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes (t2d). |
| PubMedID- 21515838 | Recently, two large clinical trials—the japanese primary prevention of atherosclerosis with aspirin for diabetes (jpad) trial (10) and the prevention of progression of arterial disease and diabetes (popadad) trial (11)—investigated whether low-dose aspirin reduced cardiovascular events in patients with diabetes but without cardiovascular disease. |
| PubMedID- 23342952 | Previous work has demonstrated that osteocalcin levels are inversely associated with glucose and total adiponectin levels, fat mass, and atherosclerosis parameters in patients with type 2 diabetes [13]. |
| PubMedID- 22553973 | Hyperglycemia is considered one of the major pathogenic factors for atherogenesis and the progression of atherosclerosis in diabetes mellitus [23]. |
| PubMedID- 24461963 | To date, there is some evidence linking individual risk factors (hypertension [5], diabetes [6]) or markers of subclinical atherosclerosis [7–9] to poorer motor function, but the combined effect of vascular risk factors remains unknown. |
| PubMedID- 23484137 | The combination of hyperglyaemia and hyperlipoprotein(a) may reduce ec-derived fibrinolytic activity, which may promote the development of thrombosis and atherosclerosis in subjects with diabetes [36]. |
| PubMedID- 24739603 | These findings suggest that measuring the hemoglobin level is clinically relevant for estimating the risk of atherosclerosis in patients with diabetes categorized according to the tg-hdl ratio. |
| PubMedID- 24843652 | These results suggest that the losartan/imidapril combination might be useful to prevent the progression of atherosclerosis and nephropathy in patients with type 2 diabetes by exerting anti‐inflammatory and anti‐oxidative effects through inhibition of the ras. |
| PubMedID- 21816063 | In conclusion, our data indicate that serum uric acid levels are significantly associated with mets and carotid atherosclerosis in patients with type 2 diabetes, even after adjustment for other potential confounders. |
| PubMedID- 20495833 | In patients who had atherosclerosis with diabetes, measured levels of tnf-alpha and il-6 were significantly higher than those in patients with atherosclerosis without diabetes (p < 0.05). |
| PubMedID- 23124060 | Conclusions: plasma leptin and the leptin/sob-r ratio are associated with atherosclerosis in patients with type 2 diabetes on insulin therapy, and these associations were independent of obesity and other cardiovascular risk factors. |
| PubMedID- 26068309 | In the japanese primary prevention of atherosclerosis with aspirin for diabetes (jpad), primary prevention with aspirin did not reduce the rates of all cv events, yet the rates of fatal coronary and cerebrovascular events, a secondary end point, were reduced [23]. |
| PubMedID- 24599017 | The aim of this study was to assess whether the iad could be a marker for subclinical atherosclerosis in patients with type 2 diabetes who are at high risk of cardiovascular disease (cvd). |
| PubMedID- 25889082 | Conclusions: serum angptl2 concentration was significantly and positively associated with carotid atherosclerosis in patients with type 2 diabetes, suggesting that angptl2 may be important in the atherosclerosis in humans. |
| PubMedID- 23801796 | diabetes is associated with premature atherosclerosis (1) and increased risk of coronary artery disease (cad), which is the most common cause of death in patients with diabetes (1). |
| PubMedID- 23267397 | [13–15] pon-1 is dysfunctional due to glycation, reducing its ability to retard ldl and cell membrane oxidation and contributing to the inflammation typical of diabetes, leading to the excess atherosclerosis common in this disease. |
| PubMedID- 26162315 | In selected populations, such as those with type 2 diabetes, the role of uric acid in atherosclerosis may be result from other concomitantly atherosclerotic risk factors, such as dr. |
| PubMedID- 23375680 | Conclusion: reduction of glucose excursion due to dpp-iv inhibitors administration, may prevent atherosclerosis progression in patients with type 2 diabetes probably through the reduction of daily inflammation and oxidative stress. |
| PubMedID- 26213526 | The role of rage has been observed in the development of accelerated atherosclerosis associated with diabetes (basta et al. |
| PubMedID- 26064988 | In conclusion, the fmd is considered to be useful for the detection of atherosclerosis in patients with type 2 diabetes, even if overt macroangiopathy is not diagnosed. |
| PubMedID- 26388951 | Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in type 2 diabetes (boat2 study). |
| PubMedID- 26223257 | The jpad study (japanese primary prevention of atherosclerosis with aspirin for diabetes) analyzed the effect of asa, 81–100 mg, in patients with type 2 diabetes in primary prevention of atherosclerotic events. |
| PubMedID- 26251624 | The development of atherosclerosis in patients with type 2 diabetes mellitus (t2dm) may be due to hypercoagulability and platelet hyperaggregability,1,2 along with increased levels of platelet activation markers. |
| PubMedID- 20605247 | According to the levels of carotid intima-media thickness (cimt), 36 diabetic patients were classified into two groups, the diabetes mellitus without atherosclerosis (dm-as, n=20) and diabetes mellitus with atherosclerosis (dm+as, n=16). |
| PubMedID- 20451957 | Introduction: diabetes mellitus is complicated by accelerated atherosclerosis, resulting in an increased risk of coronary artery disease (cad) and thrombosis. |
| PubMedID- 22923915 | The increased platelet size may be one factor in the increased risk of atherosclerosis associated with diabetes mellitus and associated vascular complications. |
| PubMedID- 20724653 | The rate of cardiovascular events excluding noncardiac death and heart failure in the j-access 2 study of 56 events over a period of 3 years was also 2.3-fold higher than that (1.7% per annum) of the nonaspirin group in the more recent japanese primary prevention of atherosclerosis with aspirin for diabetes (jpad) study of asymptomatic japanese patients with type 2 diabetes (18). |
| PubMedID- 25602196 | While in human atherosclerosis study, in patients with type 2 diabetes, an average annual increase of imt 0.02 mm/year has been reported [17,18]. |
| PubMedID- 26041310 | Cardiac ct in asymptomatic diabetes mellitus: role of non-invasive atherosclerosis imaging in high-risk asymptomatic individuals. |
| PubMedID- 20361178 | This pathogenic sequence establishes the molecular basis linking insulin resistance, inflammation and accelerated atherosclerosis in people with type 2 diabetes mellitus and may help account for the missing 30% cvd risk that cannot be explained by circulating cardiovascular risk factors [74, 76] (fig. |
| PubMedID- 23533715 | The underlying mechanisms that cause accelerated atherosclerosis in patients with diabetes and consequently an increased prevalence of cvd are poorly understood. |
| PubMedID- 25422776 | Therefore, early detection of atherosclerosis in individuals with diabetes is crucial in reducing the risk of cardiovascular, cerebrovascular and amputation events. |
| PubMedID- 20200310 | The suppression of at least two (mcp-1 and rantes) of the three (mcp-1, rantes, and fractalkine) most important chemokines involved in the pathogenesis of atherosclerosis in patients with type 2 diabetes is relevant because two-thirds of mortality in this condition is attributable to atherosclerotic complications of coronary heart disease, cerebrovascular disease, and peripheral arterial disease. |
| PubMedID- 23695772 | Conclusions: treatment with either aliskiren or amlodipine did not significantly alter surrogate biomarkers of atherosclerosis in patients with both diabetes and established cardiovascular disease already receiving appropriate secondary cardiovascular prevention therapy. |
| PubMedID- 23678326 | Chronic subclinical inflammation is considered to be important for the initiation and / or progression of atherosclerosis in patients with diabetes mellitus. |
| PubMedID- 23844137 | The expression of the age receptor rage is upregulated in endothelial cells, smooth muscle cells, and mononuclear phagocytes in diabetic vasculature, and such upregulation is linked to the inflammatory response [49], [50], and it accelerates the development of atherosclerosis in patients with diabetes [13]. |
| PubMedID- 21545576 | Increasing evidence indicates that resistin plays important regulatory roles apart from its role in insulin resistance and diabetes in a variety of biological processes: atherosclerosis and cardiovascular disease (cvd), non-alcoholic fatty liver disease, autoimmune disease, malignancy, asthma, inflammatory bowel disease and chronic kidney disease. |
| PubMedID- 20508233 | Two recent trials, the japanese primary prevention of atherosclerosis with aspirin for diabetes (jpad) (9) and the prevention of progression of arterial disease and diabetes (popadad) (10), and one older trial, the early treatment of diabetic retinopathy study (etdrs) (18), enrolled only patients with diabetes. |
| PubMedID- 26399335 | In conclusion, af might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively. |
| PubMedID- 21359834 | The approach (assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history) study was a double-blind randomized clinical trial comparing the effects of rosiglitazone with glipizide on the progression of coronary atherosclerosis [1, 2]. |
| PubMedID- 23904855 | In this study, the total number for atherosclerosis in patients with type 2 diabetes mellitus increased with the progression of renal dysfunction. |
| PubMedID- 22124705 | Endothelial cell dysfunction can release large amounts of ros, including o2−, h2o2 and no, that promote abnormal vascular growth, such as atherosclerosis in patients with diabetes mellitus (11). |
| PubMedID- 21398528 | The mechanism for advanced atherosclerosis in patients with diabetes is almost certainly multifactorial. |
| PubMedID- 20134102 | Genetic risk factors and the anti-atherosclerotic effect of pioglitazone on carotid atherosclerosis of subjects with type 2 diabetes--a retrospective study. |
| PubMedID- 22996180 | Furthermore, they were consistent with the likelihood that insulin sensitization will protect patients with diabetes from acceleration of coronary atherosclerosis and precipitation of acute coronary syndromes including mi. |
| PubMedID- 23755169 | diabetes increases atherosclerosis in the descending aorta, but the overall plaque area is lower than in the aortic arch. |