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PedAM

Pediatric Disease Annotations & Medicines




Disease vaccinia
Symptom C0009450|infection
Sentences 90
PubMedID- 20457790 In contrast, peak tskb20-specific cd8+ t-cell responses generated during infection with vaccinia virus engineered to express tskb20 were approximately 2.5-fold lower in ifnarko mice than b6 mice, although after viral clearance, the frequencies of tskb20-specific cd8+ t cells stabilized at similar levels.
PubMedID- 23595147 Briefly, functional bunv rnps were assembled in confluent bhk-21 monolayers by infection with vaccinia virus recombinant vtf7-3, followed by transfection with cdnas expressing either wild-type or mutant n proteins, l protein or the bun-s(ren) replicon template.
PubMedID- 26431533 Found that infection with either vaccinia virus, att l. monocytognes, or virulent l. monocytogenes differentially regulated the kinetics, magnitude, and phenotype of 1° and 2° cd8 t cells in the same host .
PubMedID- 24210117 Our strategy involved (i) construction of a cell line that stably expressed the three late transcription factors, (ii) infection with a vaccinia virus mutant that expresses rna polymerase but neither intermediate nor late transcription factors, and (iii) transfection with plasmids containing a luciferase reporter regulated by an intermediate promoter.
PubMedID- 20526343 Surprisingly, infection with wild-type vaccinia virus also triggered cns autoimmunity as efficiently as recombinant virus expressing mbp despite a lack of cross-reactivity between the 8.8 tcr and viral epitopes.
PubMedID- 23202496 However, ns5a was able to inhibit pkr activation and subsequent eif2α phosphorylation in the context of infection with a vaccinia virus in which the e3l protein, a powerful pkr inhibitor, was replaced by ns5a .
PubMedID- 26074923 Have shown that during experimental infection with recombinant modified vaccinia virus ankara (mva), viral vector used for vaccine purposes, nk cells accumulated in ln and became activated in an ifn-dependent manner.
PubMedID- 22761378 Stable antigen is most effective for eliciting cd8+ t-cell responses after dna vaccination and infection with recombinant vaccinia virus in vivo.
PubMedID- 22182243 Annulata- transformed cells were shown to express high levels of cd40 and cd80 and were susceptible to infection with bhv-1, vaccinia and canarypox viruses.
PubMedID- 22991336 In a novel animal model of ms, sjl/j mice primed through infection with a recombinant vaccinia virus (vv) encoding myelin proteolipid protein (plp) (vv(plp)) were susceptible to a central nervous system (cns) inflammatory disease following administration of a nonspecific immunostimulant complete freund's adjuvant (cfa) plus bordetella pertussis (bp).
PubMedID- 21829360 We now show that an innate memory immune response is generated in mice following infection with vaccinia virus, a poxvirus for which no cognate germline-encoded receptor has been identified.
PubMedID- 22102816 After intradermal infection with vaccinia virus (vacv), a natural peripheral route of infection .
PubMedID- 21994614 In this model, isg15−/− mice display almost no differences from wt mice following infection with wild type vaccinia virus.
PubMedID- 23762027 The next day expression of polio proteins was induced by infection of cells with vaccinia-t7 virus.
PubMedID- 22140256 In mouse macrophages, transfected dna or infection with modified vaccinia virus ankara (mva) can trigger cell death via the absent in melanoma 2 (aim2) inflammasome.
PubMedID- 23049897 These data indicate that macrophages might play an important role in infection and replication of the vaccinia virus glv-1h68 in lymph node metastases.
PubMedID- 20300608 In a mouse model of infection with vaccinia virus (vv), the most studied member of the poxvirus family, we identified that the toll-like receptor (tlr) 2-myeloid differentiating factor 88 (myd88) pathway was critical for the activation of nk cells and the control of vv infection in vivo.
PubMedID- 23985697 Here, infection with lister strain vaccinia virus led to phosphatidylserine externalization (figure 2a), dna fragmentation (figure 2b), and some parp cleavage (figure 2d) and, superficially, these observations imply that vaccinia induces apoptosis.
PubMedID- 19955184 Indeed, mcl-1 was able to replace the function of f1l during infection with a vaccinia virus devoid of f1l, as demonstrated by the inhibition of bak activation, cytochrome c release, and parp cleavage (figs.
PubMedID- 21835795 Myxoma virus is nonpathogenic in mice, whereas systemic infection with vaccinia virus can be lethal even in immunocompetent mice.
PubMedID- 22144897 Diminished effector functions of memory cd8+ t cells in ifnar-/- mice have been described after infection with influenza and vaccinia (vv) viruses , .
PubMedID- 26468539 What this study demonstrates is that nk cells are recruited, activated and contribute to protection of the lung during a severe respiratory infection with vaccinia virus.
PubMedID- 21429247 This can probably be explained by the low infection efficiency (10%) of our recombinant vaccinia viruses for b cell lines like hodgkin's lymphoma, burkitt's lymphoma and lcl (data not shown).
PubMedID- 20585572 These findings suggest that infection with vaccinia virus but not lcmv might induce factor(s) that downregulates cd127 expression in the apparent absence of type i ifns, which in turn could be linked to differences in pathogenesis including cell tropism of the virus and the assortment of host responses elicited during infection.
PubMedID- 23542740 infection with vaccinia virus expressing an irrelevant antigen, chicken ovalbumin (vv-ova) elicited little accumulation of memory p14 t cells within the tissue, indicating that memory cd8+ t cell recognition of cognate antigen was required.
PubMedID- 26150805 It is possible that the cleavage observed upon transfection of fmdv 3abc was attributable to infection with vaccinia virus encoding a t7 rna polymerase prior to transfection to facilitate 3abc expression from the t7 promoter-containing plasmid.
PubMedID- 21257966 In models of infection with vaccinia virus (vv) and listeria monocytogenes, cd4 t cell help is critical for the survival of activated cd8 t cells during both the primary and memory recall responses.
PubMedID- 25008920 Chemokine (c-c motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus ankara.
PubMedID- 22768099 Cortactin tyrosine phosphorylation is dependent on the pathogen: it occurs upon infection with shigella, vaccinia virus and cryptosporidium–, whereas cortactin phosphorylation is not necessary for uptake of epec and ehec .
PubMedID- 22606294 We observed that infection of pdcs with δe3l vaccinia virus fails to induce ifn-α and tnf secretion, however, implying that additional inhibitors are produced by the δe3l vaccinia virus in human pdcs.
PubMedID- 24504800 In both hela.b27 cells and mouse fibroblasts expressing hla-b27, the absence of erap1 reduced peptide recognition by hla-b27-restricted kk10-specific ctls following infection with recombinant vaccinia virus or transfection with minigenes expressing kk10 precursors.
PubMedID- 24516642 In panel c, formation of s8l/h2-kb complexes at the cell surface of ide wt and ko c57bl/6 mefs was evaluated 6 h after infection with vaccinia viruses expressing ova or not (ctrl), by staining cells with mab 25d1.16; numbers indicate the mfi for 25d1.16.
PubMedID- 20351693 Next we investigated the role of aim2 in the innate immunity of macrophages against cytosolic dna produced by infection with vaccinia virus.
PubMedID- 21589893 Slight modifications were made to test infection with recombinant vaccinia virus (rvv) expressing nef from hiv-1 clade d isolate hiv-194ug114.
PubMedID- 24606807 Intrathecal infection with vaccinia virus (vv) was controlled in vaccinated mice when cd4+ and cd8+ t cells had access to the cns compartment.
PubMedID- 23945545 Recently, martinez and co-workers showed that psg1 affects the maturation of bone-marrow derived dendritic cells and that intra-peritoneal infection of mice with a vaccinia virus expressing psg1 promoted the expansion of ag specific cd4+ cd25+ foxp3+ treg cells in response to listeria monocytogenes infection 21. in our experiments, using a different model, we observed an increase in the frequency of cd4+ cells expressing foxp3 and cell surface lap.
PubMedID- 22617838 Intranasal infection with vaccinia virus co-expressing interferon epsilon (vv-hiv-ifn-epsilon) was used to evaluate the role of ifn-epsilon in mucosal immunity.
PubMedID- 24146620 Unfortunately, t7-polymerase has previously been shown to occasionally insert non-templated adenosine residues into rna transcribed from sequences encoding 7 adenosine residues 4, although at least parts of these observations were performed using infection with a recombinant vaccinia virus as the source for t7-polymerase, which differs from our minigenome assays.
PubMedID- 21533147 Responses to infection with vaccinia virus, a dsdna virus, are also suppressed in cells lacking lgp2, reinforcing the ability of lgp2 to act as a positive regulator of antiviral signaling.
PubMedID- 20169189 In this paper we demonstrate that direct presentation occurs and is the main pathway to induce cd8+ t cells during infection with vaccinia virus.
PubMedID- 25548218 Complement component c5 recruits neutrophils in the absence of c3 during respiratory infection with modified vaccinia virus ankara.
PubMedID- 22815909 This has been observed during the response of mice to infection with vaccinia virus, where a subset of ly6chi inflammatory monocytes produces type i ifn in an irf3 and irf7-dependent manner after tlr2-mediated recognition of viral ligands .
PubMedID- PMC3990307 Importantly, virus infection with the oncolytic vaccinia virus constructs correlated with the disease progression in these patients.
PubMedID- 26485703 While the longevity of trm cells relative to circulating memory cd8 t cells is unclear at present, some studies have indicated that trm cells remain in mice for at least 300 days following infection with vaccinia virus , herpes virus , or vesicular stomatitis virus .
PubMedID- 21994622 In support of this, our recent observations indicate that upon infection with vaccinia virus the ubiquitin proteasome system is fully functional .
PubMedID- 20224775 Previous reports have highlighted that infection of cells with vaccinia virus can result in the processing of the fcv lc-vp1 into the mature vp1 protein , .
PubMedID- 21541224 Several plasmids have been utilized in this respect, and perhaps the most successful one is ptm1-2a, which is transfected in mammalian cells that transiently express t7 rna polymerase by infection with a recombinant vaccinia t7 virus .
PubMedID- 22084408 In support of this, infection with vaccinia virus (vacv) did not elicit high levels of systemic ifn-i or cause a dramatic reduction in pdc numbers (fig.
PubMedID- 22970293 It was only presented when the tumor cells were first ifn-gamma treated, followed by infection with recombinant vaccinia virus encoding ny-eso-1, which dramatically increased ny-eso-1 expression.
PubMedID- 23544011 Provision of the t7 polymerase by co-infection with vaccinia virus recombinant vtf7.3, effectively lowers the cytotoxicity due to 3c protease or its capsid product; use of an inducible promoter regulates the expression levels of the p1-2a-3c cassette compared to that of a constitutive promoter .

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