PedAM

Pediatric Disease Annotations & Medicines

Disease	vaccinia
Symptom	\|infection
Sentences	90
PubMedID- 21161320	This study confirmed that sting is indeed required for effective dna-mediated adaptive immune responses, such as those stimulated by plasmid dna vaccination as well dna virus infection such as with vaccinia virus .
PubMedID- 22723794	Aim2 knockdown has been shown to reduce such inflammasome formation and caspase-1 activation in response to dsdna administration and infection with vaccinia virus (hornung et al., 2009) and stable transfection of cell-lines with aim2 has been demonstrated to confer responsiveness to cytoplasmic dna (fernandes-alnemri et al., 2009).
PubMedID- 21788406	In fact, after systemic infection with recombinant vaccinia virus expressing ova (vv-ova), antigen-specific cd8+ t cells uniformly express cxcr3 at day 7, and high-level cxcr3 expression on memory cd8+ t cells is evident at least 70 d later (fig.
PubMedID- 25643352	For example, low-level expression of cxcl9 was described in ifnγ-/- mice following infection with vaccinia virus .
PubMedID- 24891667	other causes are infection with mycoplasma pneumoniae, vaccinia, or varicella zoster virus (vzv); immunizations; and a wide variety of physical agents.
PubMedID- 26388843	infection with mature vaccinia virus triggers pi3k/akt signaling, and blocking p13k activation can reduce viral entry in an β1-integrin-dependent manner, suggesting that β1 integrin-mediated pi3k/akt activation is induced by vaccinia virus (izmailyan et al., 2012).
PubMedID- 24440909	Similarly, depletion of arc in vivo exacerbated necrosis caused by infection with vaccinia virus, which elicits severe tissue damage through this pathway, and sensitized mice to tnfalpha-induced systemic inflammatory response syndrome.
PubMedID- 26015944	Delivery of adifn-α was observed to be protective when given 14 and 56 days before infection with sars and vaccinia virus, respectively.17,20 we have also previously shown that i.n.
PubMedID- 23741313	This was followed by infection with a vaccinia virus (vv), which encoded the t7 rna polymerase, at 8 h post-transfection.
PubMedID- 23533650	Glycoproteins were transiently expressed in cells by plasmid transfection and infection with recombinant vaccinia viruses.
PubMedID- 22101430	In reciprocal experiments, cd4 t cells activated during infection with pv, mhv, vaccinia virus (vv), and mcmv were lost upon transfer into mice infected with medium dose lcmv when nk cells were present (fig.
PubMedID- 23825958	Indeed, infection with vaccinia virus alone promoted a measurable increase in dttp, datp, and dgtp concentrations in mdms (fig.
PubMedID- 22811544	These dc were of interest given that our previous studies using a model of respiratory infection with vaccinia virus revealed a distinct difference in the ability of cd103(+) dc to prime t cells that correlated inversely with the expression of cd8, suggesting a differential role of these dc in the context of respiratory virus infection.
PubMedID- 22798671	Previous studies have shown that nk cells are efficiently activated in response to infection with vaccinia virus (vv), the most studied member of the poxvirus family.
PubMedID- 21267444	Cells were plated in 6 or 12 well plates and incubated for 24 hours before infection with vaccinia new york board of health (wyeth, dryvax) (vac-ny), vaccinia western reserve (vac-wr, , kindly provided by b. moss, nih, bethesda), or monkeypox-zaire (mpv-zai, cdc isolate v79-i-005 ), each at a multiplicity of infection (moi) of 10. control infections with ebola-zaire (ebov-zai) were also at an moi of 10. control killed virus infections were performed with gamma-irradiated mpv-zai.
PubMedID- 23874722	We have developed other infection models with cowpox and vaccinia viruses in healthy immunocompetent mice.
PubMedID- 23733873	Nk cells play an important role in innate immune control of the infection with vaccinia virus (vv).
PubMedID- 22054309	One of the more easily available and more commonly used murine models is infection with a recombinant vaccinia virus encoding the protein of interest .
PubMedID- 25609844	In this article, we report that, in a murine model of cutaneous infection with vaccinia virus, dermal gammadelta t cell numbers increased 10-fold in the infected ear and resulted in a novel gammadelta t cell population not found in naive skin.
PubMedID- 20585561	Moreover, ampk becomes rapidly activated upon infection with vaccinia, suggesting that virus-induced signals converge on this complex to facilitate entry.
PubMedID- 22363320	After infection with vaccinia virus expressing the t7 rna polymerase, wild-type mv expressing egfp can be recovered by mixing with b95a cells.
PubMedID- 21689420	In immunocompetent individuals, infection with vaccinia or cowpox viruses usually only results in localized rash illness.
PubMedID- 21257961	The adiins3-induced cd8(+) t cells protected mice from infection with recombinant vaccinia virus expressing hcv ns3 of heterologous 1b strains, and studies in knockout mice demonstrated that this protection was mediated primarily through ifn-gamma production.
PubMedID- 24351799	infection with the enveloped vaccinia virus (vacv) also causes a clustering of lipid rafts at the host plasma membrane, leading to co-localization of virus and raft-associated integrin β, which finally activates the pi3k/akt signaling pathway to support endocytosis of the virus .
PubMedID- 20631910	Taken together, we did not find any evidence of possible resistance of canine carcinoma cancer mth52c cells to infection with vaccinia virus in cell culture.
PubMedID- 22852044	However, trm lodgment is not always dependent on cd4 t cell help as shown for skin infection with vaccinia virus .
PubMedID- 21830209	Using cd8(+) t cells deficient for il-12 or type i ifn receptors in an adoptive transfer system, we generated memory populations after infection with vaccinia virus, lymphocytic choriomeningitis virus or listeria monocytogenes.
PubMedID- 21526210	Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with vaccinia virus.
PubMedID- 21715499	These cd8 t cells were sufficient to provide protection from lethal respiratory infection with live vaccinia virus independent of cd4 t cells and antibody.
PubMedID- 25889495	Therefore we examined the potential of the murine alveolar macrophage mh-s cell line as a model to study chemokine expression during infection with mva and vaccinia virus (vacv) strain western reserve (wr).
PubMedID- 23531320	That gfp marker gene expression intensity upon infection with oncolytic vaccinia virus is cell line-dependent .
PubMedID- 22787205	Furthermore, ta was not modified during monocyte-macrophage differentiation, mdm activation, or infection with vaccinia virus.
PubMedID- 25505074	This report shows that transgenic expression of an mcl1 protein enhances survival of memory cd8(+) t cells following infection with vaccinia virus.
PubMedID- 20547825	Notably, lapc trafficking from infected tissues to the associated dlns was also observed after respiratory infection with vaccinia virus (vacv) and cardiotropic infection with coxsackievirus b3 (cvb3).
PubMedID- 22534090	Production of prostaglandin e(2) in response to infection with modified vaccinia ankara virus.
PubMedID- 23737745	The assembly model proposed here reveals how multiple mimivirus progeny can be continuously and efficiently generated and underscores the similarity between the infection cycles of mimivirus and vaccinia virus.
PubMedID- 21687408	infection with the modified vaccinia virus ankara also activates the nlrp3 inflammasome (delaloye et al., 2009).
PubMedID- 23372568	However, a few studies have shown some downregulation of mouse and human mhc-i during infection with vaccinia virus or ectromelia virus.
PubMedID- 23577120	To answer this question, we developed an assay for intracellular staining of poxvirus infection with a polyclonal anti-vaccinia antibody.
PubMedID- 21604559	Methods: infection with one recombinant vaccinia virus rvvj18 e7, e6 respectively in c57 bl/6 and balb/c mice, specific cellular immune responses were detected by elispot or intracellular cytokine stainings by using a series of overlapping synthetic peptides covering full length of the amino acid sequence of e6 and e7 proteins or various truncated peptides.

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