PedAM
Pediatric Disease Annotations & Medicines
| Disease | asthma |
| Symptom | |obesity |
| Sentences | 104 |
| PubMedID- 25849982 | Interestingly, a similar developmental pattern was observed in offspring of mice exposed to human igg antibodies of mothers with a child diagnosed with autism.50 prenatal exposure to environmental insults, including factors contributing to allergies and asthma, are associated with childhood obesity,51 a condition that includes both systemic and neuro-inflammation.52 increased weight gain in offspring of maa dams may represent priming and reprogramming of metabolic function through both immune and nervous system mechanisms, as has been previously hypothesized.53, 54 in fact, a recent examination of metabolic changes in immune cells of mice born to dams exposed to a viral mimic revealed persistent mitochondrial dysfunction in splenocytes.55, 56 interestingly, comorbid metabolic dysregulation is highly prevalent in neurodevelopmental disorders including asd,57 adhd58 and schizophrenia,59 suggesting that environmental insults may impart pervasive changes in homeostasis and regulation across organ systems. |
| PubMedID- 20626634 | Background: most studies regarding the association of obesity with asthma have been performed in the western countries. |
| PubMedID- 23915208 | asthma is associated with dt2 and obesity , both of which are metabolic disorders with an underlying systemic inflammatory profile. |
| PubMedID- 25478171 | These mechanisms go on to impact immune and inflammatory responses, muscular and nervous system mechanisms, and hormonal and obesity-related mechanisms, all of which relate to asthma.12–15 studies on asthma prevalence have also attributed some of the disease burden to environmental risk factors, including poor control of pollutants (toxins, dust and mites) in the household.36–42 there is also some evidence on clustering or co-occurrence of risks of disadvantages (socioeconomic, adversity and environmental risks) within households.14364344 studies have, in the past, examined the relationships between stress during pregnancy and postpregnancy and asthma among children.9 the scope for connecting pregnancy and early life exposures to childhood adversity was not available in the brfss surveys, and needs to be investigated in future analyses. |