PedAM
Pediatric Disease Annotations & Medicines
| Disease | asthma |
| Symptom | |obesity |
| Sentences | 104 |
| PubMedID- 23392439 | Rationale: obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. |
| PubMedID- 21525083 | In adolescents, approximately 20% received recommended laboratory screening and overweight/ obesity was significantly associated with chart-documented asthma, back pain, prediabetes, gastroesophageal reflux disease, hypertension, and sleep apnea. |
| PubMedID- 24204385 | A number of cellular signaling and metabolism mechanisms could contribute to increased asthma risk in patients with obesity and/or metabolic syndrome. |
| PubMedID- 26426429 | Across all age groups, obesity was associated with poorer asthma outcomes: either poor asthma control (odds ratio (or)=2.3, 95% confidence interval (ci) 1.1-4.7 in 5- to 11-year-olds and or=1.5, 95% ci 1.1-2.2 in adults) or asthma exacerbations (or 2.9, 95% ci 1.6-5.1 in 12- to 18-year-olds and or 1.7, 95% ci 1.1-2.5 in adults). |
| PubMedID- 26111352 | Background: obesity is associated with asthma risk and severity, but the underlying biological mechanisms are poorly understood. |
| PubMedID- 22768385 | obesity in children with asthma appears to be associated with greater airflow obstruction and a mildly diminished response to inhaled corticosteroids. |
| PubMedID- 24220581 | Overweight and obesity were associated with increased asthma severity in all of the patients and with worse control of the disease among the patients with more severe disease, older patients and patients with a longer duration of asthma. |
| PubMedID- 24008330 | The joint association of anxiety, depression and obesity with incident asthma in adults: the hunt study. |
| PubMedID- 19844182 | A wealth of epidemiologic literature has established that whereas asthma can lead to obesity, obesity is a risk factor for asthma, but mechanisms are unclear. |
| PubMedID- 23923994 | Conclusions: obesity in asthmatics is associated with shorter and very long sleep duration, worse asthma severity, psychopathology and high-dose inhaled corticosteroids. |
| PubMedID- 21429056 | With obesity the risk of comorbidity such as asthma, obstructive sleep apnea, hypertension, and diabetes increases. |
| PubMedID- 22335609 | Active smoking and obesity were positively associated with asthma without rhinitis. |
| PubMedID- 24142648 | We used the same mouse model of chronic asthma with or without obesity as we previously described.10 mice were divided into 4 groups: a control group, an asthma group, an obese group, and an obese asthma group. |
| PubMedID- 22360643 | Even in preschool children, obesity is already associated with asthma, and there was no gender effect on this association. |
| PubMedID- 24885269 | After adjusting for sex, age, andco-morbidities, including obesity, patients with asthma developed ckd (hr: 1.13 , p < 0.001) compared to hr before the adjustments (hr: 1.56 , p < 0.001) (table 3). |
| PubMedID- 23710195 | Role of obesity in asthma control, the obesity-asthma phenotype. |
| PubMedID- 25859274 | These results are similar to those of other studies that have clustered clinical, inflammatory and functional profiles pointing to a more symptomatic asthma associated with obesity in women . |
| PubMedID- 23941287 | The combined risk ratio (rr) of obesity was associated with asthma in both boys and girls (rr = 1.50; 95% ci = 1.22, 1.83), in boys only (rr = 1.40; 95% ci = 1.01, 1.93) and in girls only (rr = 1.53; 95% ci = 1.09, 2.14). |
| PubMedID- 22742416 | 4 showed that obesity was associated with asthma symptoms only in the least obstructed tertile, as measured by the ratio of fev1 (forced expired volume in one second) to fvc (forced vital capacity). |
| PubMedID- 20100278 | Background and purpose: obesity is associated with deterioration in asthma outcomes. |
| PubMedID- 22520186 | obesity was particularly associated with apoplexy, paralysis, asthma and putrid fevers, and a range of therapeutic options was proposed. |
| PubMedID- 26321758 | Epidemiological studies associate obesity with onset of asthma, especially in obese children, suggesting obesity as the risk factor for asthma. |
| PubMedID- 25979684 | Moreover, all the degrees of obesity are associated with asthma (or type i obesity: 1.33; or type ii obesity: 1.69; or type iii obesity: 1.75), heart failure (or type i obesity: 1.68; or type ii obesity: 2.78; or type iii obesity: 4.35), and severe mental disorders (or type i obesity: 2.02; or type ii obesity: 2.33; or type iii obesity: 2.50). |
| PubMedID- 21195942 | Conclusions: obesity was not associated with worse asthma severity, spirometry findings, qol, or hcu in children. |
| PubMedID- 24409194 | There are also several clinical observations suggesting the role of obesity with asthma and one of the major conclusions so far has been the action of adipocytes derived cytokines which inhibit the activity of t-regs thus decreasing the tolerance (theoharides et al., 2008). |
| PubMedID- 24600294 | In a cross-sectional case control study of over 1100 children aged 5–18 years recruited from a single outpatient allergy/immunology clinic, investigators asked whether obesity was associated with allergic asthma in children.25 they were specifically interested in whether the distribution of obesity was important in the relationship between obesity and asthma diagnosis, lung function, and symptom burden. |
| PubMedID- 20334698 | The cross sectional nature of this study prevents conclusions on a causal relationship between asthma with obesity or psychological well-being in ethnic minorities. |
| PubMedID- 23035704 | Further studies are necessary to establish the real diagnosis of asthma that is associated with obesity, as well as to rule out that the association is dependent on the respiratory symptoms caused by obesity. |
| PubMedID- 21992497 | Despite more than a decade of research into this association, the exact mechanisms that underlie the interaction of obesity with asthma remain unclear. |
| PubMedID- 26538828 | Because many players are involved in obesity, the etiology of obesity-related late-onset asthma is not simple and straightforward. |
| PubMedID- 26006753 | Conclusion: our data confirm that both underweight and obesity are associated with current asthma and obesity with copd. |
| PubMedID- 23646295 | Objective: we hypothesized that asthmatic children with obesity, defined as a body mass index above the 95th percentile for age and sex, would have poorer asthma control as well as decreased quality of life, increased health care utilization, and decreased pulmonary function measures as a function of increased th1 versus th2 polarization. |
| PubMedID- 24739266 | Conclusions: overweight and obesity increased the prevalence of symptomatic asthma in adults, especially in women. |
| PubMedID- 26365093 | Association of asthma with obesity among adolescents exposed to environmental tobacco smoke. |
| PubMedID- 23636141 | Examples of these phenotypes include early-onset mild allergic asthma, later-onset asthma associated with obesity, and severe non-atopic asthma with frequent exacerbations. |
| PubMedID- 24669757 | Low physical fitness levels and high screen time increase the risk of central obesity, which leads to asthma development. |
| PubMedID- 26225211 | Despite more than a decade of research into this association, the exact mechanisms that underlie the interaction of obesity with asthma remain unclear. |
| PubMedID- 25742612 | Background: obesity is associated with poor asthma control, increased asthma morbidity, and decreased response to inhaled corticosteroids. |
| PubMedID- 20525713 | The obesity phenotype associated with asthma is not known. |
| PubMedID- 25947112 | Although the mechanisms linking obesity with asthma expression have not been completely elucidated, evidence suggests that increased frequency of acute respiratory infection (ari) and decreased corticosteroid responsiveness may help to explain how obesity worsens asthma expression. |
| PubMedID- 23710196 | Although obesity is associated with less asthma control, greater risk of asthma exacerbations, and reduced inhaled corticosteroid efficacy, whether in fact these conditions are causally related remains uncertain 1. |
| PubMedID- 23240044 | Overweight and obesity do not lead to asthma in asian immigrant children in usa . |
| PubMedID- 23828644 | Mouse studies have helped us to uncover the underlying inflammatory mechanisms (mediated by multiple immune cell types that produce th1, th2 or th17 cytokines) and non-inflammatory pathways, in addition to shedding light on asthma that is associated with obesity or steroid unresponsiveness. |
| PubMedID- 25342709 | The pathogenesis of late-onset th2-low asthma in obesity is thought to be related to weight-related decreases in lung volume, but why only a subset of individuals with obesity develop this condition is unknown. |
| PubMedID- 23273317 | A possible explanation for this results might be a selection bias, in particular overdiagnosis of asthma attributable to non specific obesity-related respiratory symptoms among obese children. |
| PubMedID- 22653771 | Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression. |
| PubMedID- 26226354 | obesity is independently associated with decreased asthma control. |
| PubMedID- 24676351 | Background: obesity has been associated with worse asthma control. |
| PubMedID- 26485533 | We found associations between pre-pregnancy obesity and higher risks of ever asthma and current wheezing at age 7–8 years. |
| PubMedID- 26098111 | The association of obesity with asthma is now well known, with many mouse and human studies confirming this link. |