PedAM
Pediatric Disease Annotations & Medicines
| Disease | neuropathy |
| Symptom | |pain |
| Sentences | 130 |
| PubMedID- 25503082 | Background and objective: data from two similarly designed studies of tapentadol extended release (er) for managing neuropathic pain associated with diabetic peripheral neuropathy (dpn; nct00455520, nct01041859) in adults were pooled for this analysis, allowing a detailed evaluation of efficacy in patient subgroups and secondary endpoints. |
| PubMedID- 22003419 | Inhalants can also cause peripheral neuropathy leading to chronic pain and vision-impairing optic nerve damage (e.g., twardowschy et al., 2008). |
| PubMedID- 25031994 | Patients spontaneously describe positive benefits, which include feeling peaceful and relaxed, feeling decreased anxiety for making treatment decisions, improved sleep quality, decreased pain, increased mobility with peripheral neuropathy, strengthened self-perception, increased receptivity to other complementary and alternative modalities, and increased peaceful feelings at the end of life. |
| PubMedID- 21411507 | A variety of factors may be responsible for the higher insomnia prevalence among those with diabetes, including increased pain associated with neuropathy, nocturia, poor glucose control, and sleep-disordered breathing. |
| PubMedID- 26464604 | Trigeminal neuropathy manifesting with atypical dental pain, as in our patient, has been reported rarely. |
| PubMedID- 26055637 | pain and dysautonomia with an axonal neuropathy and multisystemic involvement raised the possibility of amyloidosis. |
| PubMedID- 23608387 | Iliopsoas muscle hematoma can cause femoral neuropathy with resultant pain and paralysis. |
| PubMedID- 21713059 | Pregabalin (lyrica) is a second-generation compound structurally related to gabapentin and approved in the us for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and as adjunctive therapy for adults with partial onset seizures and for generalized anxiety disorder (gad). |
| PubMedID- 23294138 | Objectives: pain due to peripheral neuropathy is extremely difficult to treat as drugs often become less and less effective over the course of a patient's life. |
| PubMedID- 21298560 | However, in recent years, the growing use of specialized tests such as skin biopsy and sudomotor testing has helped to establish the diagnosis of small-fiber neuropathy as the cause of pain in these patients via objective and quantifiable means. |
| PubMedID- 22574283 | Spinal application of cb2r agonists to control allodynia produced by cci, a widely used and well-characterized rodent model of chronic peripheral neuropathy with related pain-like behaviors (bennett and xie 1988). |
| PubMedID- 21166852 | Aims: to evaluate the efficacy, safety and pharmacokinetics of pregabalin in treating neuropathic pain associated with diabetic peripheral neuropathy in japanese patients. |
| PubMedID- 25594611 | Subjects: patients with pain due to diabetic peripheral neuropathy (dpn) or postherpetic neuralgia (phn). |
| PubMedID- 21621670 | Objective: to evaluate whether or not spinal accessory neuropathy exists in patients with cervical myofascial pain syndrome (mfps). |
| PubMedID- 20556211 | Duloxetine has been proven superior to placebo in three 12-week randomized, placebo-controlled trials that enrolled patients with pain due to diabetic peripheral neuropathy . |
| PubMedID- 21851615 | Stz has been widely used to induce type 1 diabetes in rodents for the study of pain associated with diabetic neuropathy . |
| PubMedID- 24848284 | Objective: this study evaluated the efficacy and tolerability of tapentadol extended release (er) for the management of chronic pain associated with diabetic peripheral neuropathy (dpn). |
| PubMedID- 20393345 | Overall, for patients who will respond to pregabalin, statistically significant and sustained reduction of pain associated with diabetic peripheral neuropathy and posttherapeutic neuralgia occurs early, usually by the end of 2 days of pregabalin treatment. |
| PubMedID- 21584220 | For grade 1 neuropathy with pain and grade 2 neuropathy, the dose is decreased by 25%. |
| PubMedID- 23251813 | Chronic pain associated with neuropathy from either t1d or t2d decreased maximally in response to stretching exercises when muscle relaxants were also administered . |
| PubMedID- 21353106 | Conclusion: flexible-dose pregabalin (150-600 mg/d for 8 weeks) was associated with a significant, although modest, reduction in mean dprs score; an improvement in anxiety and subjective sleep; and generally good tolerability compared with placebo in these korean patients with neuropathic pain due to diabetic peripheral neuropathy, postherpetic neuralgia, or posttraumatic neuropathic pain. |
| PubMedID- 22619713 | Diabetic neuropathy, with neuropathic pain, is a common complication of diabetes. |
| PubMedID- 24804094 | The findings presented in the current study demonstrate that pea-m treatment resulted in a significant reduction in the pain symptoms characteristic of diabetic neuropathy already after 30 days. |
| PubMedID- 25901238 | Randomized, placebo-controlled clinical trials have shown the efficacy of pregabalin for pain relief in patients with diabetic neuropathy and peripheral neuralgia . |
| PubMedID- 22606406 | However, the pain control of diabetic neuropathy remains a daunting challenge and the overall outcomes of the current management of diabetic neuropathy are not satisfactory. |
| PubMedID- 23198755 | Stepwise approach and algorithms may be used, but comparative effectiveness of treatments to control pain in patients with diabetic neuropathy is unclear and there is no evidence of relative superiority across the different drug classes or the individual agents. |
| PubMedID- 21766021 | If successful, these studies could advance to clinical investigations into the safety and efficacy of hsv-gad for attenuating pain in individuals with diabetic neuropathy . |
| PubMedID- 21274758 | Small-fiber neuropathy is frequently associated with pain, and these patients may present to a neurologist for evaluation before the underlying glucose dysregulation has been diagnosed. |
| PubMedID- 21719618 | Conclusion: duloxetine was noninferior to pregabalin for the treatment of pain in patients with diabetic peripheral neuropathy who had an inadequate pain response to gabapentin. |
| PubMedID- 19952054 | Goshajinkigan (gjg) is an extracted traditional japanese herbal medicine (kampo) that is mainly used for the improvement of symptoms like numbness, cold sensation and limb pain associated with diabetic neuropathy . |
| PubMedID- 26322641 | Radiprodil is an nr2b-selective nmda receptor antagonist which reached phase 2 for the treatment of neuropathic pain associated with diabetic peripheral neuropathy, but was stopped due to a lack of significant reduction in daily pain scores . |
| PubMedID- 21251268 | In randomized, placebo-controlled clinical trials, pgb demonstrated its efficacy for pain relief in patients with diabetic neuropathy and peripheral postherpetic neuralgia, significantly improving mood symptoms, sleep, and quality of life . |
| PubMedID- 25986602 | At the same time pain symptoms of diabetic neuropathy other than thermal persist in stz-diabetic animals and patients during progression of diabetes into later stages suggesting that other types of drg neurons may be sensitized and contribute to pain. |
| PubMedID- 23837006 | The early success in the treatment of trigeminal neuralgia with anticonvulsant drugs has led to many studies that have assessed their analgesic potency in treating neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.11–16 also, their analgesic efficacy after a variety of surgical procedures has also been studied.17,18 two such drugs, especially pregabalin and gabapentin, which are alfa-2-delta (α2-δ) subunit calcium channel ligands, have been widely studied. |
| PubMedID- 21951917 | Due to its importance in controlling innate immunity and inflammation, il-6 is generally accepted to contribute to pain and hypersensitivity associated with inflammation, neuropathy or cancer. |
| PubMedID- 24250157 | Some of them also have pain associated with neuropathy, also known as painful diabetic neuropathy (pdn), which is strongly associated with other diabetic complications. |
| PubMedID- 26239827 | Treatment of neuropathic pain due to small fiber neuropathy may be challenging.comorbidity and polypharmacy are more frequent in the elderly, making treatment even more challenging.especially in the elderly, topical treatment may be considered as first-line treatment, whereas tricyclic antidepressants are best avoided. |
| PubMedID- 21668963 | Duloxetine is a potent serotonin and norepinephrine reuptake inhibitor that has been approved by the us food and drug administration for treatment of major depressive disorder (mdd) and generalized anxiety disorder (gad) and for the management of pain associated with diabetic peripheral neuropathy, management of chronic musculoskeletal pain, and management of fibromyalgia. |
| PubMedID- 25821809 | Oxidative damage to peripheral nerves causes hyperexcitability in the afferent nociceptors and central neurons leading to the generation of spontaneous impulses within the axons and dorsal root ganglions of the nerves contributing to the neuropathic pain associated with diabetic neuropathy . |
| PubMedID- 20714957 | Small-fiber sensory neuropathy with neuropathic pain had been a diagnostic challenge for neurologists. |
| PubMedID- 24883061 | Although there is a range of pharmacological agents available for treating the pain associated with diabetic neuropathy, only duloxetine and pregabalin are approved by us food and drug administration (us fda) for the treatment of diabetic neuropathic pain. |
| PubMedID- 24224097 | pain due to arthralgia and/or neuropathy might have affected performances in pss patients. |
| PubMedID- 24843725 | The presence of pain in patients with diabetic neuropathy suggested that there might also be a relationship between crps and blood sugar control as a result of changes in regional cerebral blood flow in thalamus. |
| PubMedID- 23425518 | However, if there is no biopsy evidence of amyloid deposition, confounding diagnoses, such as pain due to diabetic peripheral neuropathy, need to be excluded. |
| PubMedID- 21573904 | Although we excluded patients with a known depression, use of psychotropic drugs, and co-morbid disorders (other than neuropathy) associated with pain, in our study higher depression scores were independently associated with impaired sleep quality. |
| PubMedID- 24330406 | Objective: to evaluate the predictive value of disturbed sleep on the ability of pregabalin to reduce pain associated with diabetic peripheral neuropathy (dpn) and post-herpetic neuralgia (phn). |
| PubMedID- 20827117 | Sjogren patients can suffer from severe neuropathic pain, with small-fiber neuropathy causing lancinating or burning pain which can disproportionately affect the proximal torso or extremities, and the face (ie, in a "non-length-dependent distribution"). |
| PubMedID- 24348072 | Duloxetine (cymbalta®; eli lilly and company, indianapolis, in, usa) is an snri that is approved by the us food and drug administration (fda) for the treatment of major depressive disorder and generalized anxiety disorder and the management of neuropathic pain associated with diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic low back pain. |
| PubMedID- 23975329 | Dlts were defined as treatment-related ≥grade 2 neuropathy with pain, ≥grade 3 non-hematologic toxicity, grade 4 neutropenia or thrombocytopenia lasting 7 or more days, or thrombocytopenia with bleeding. |
| PubMedID- 20487048 | Methods: a prospective, multicentre, open-label, non-comparative study included patients age >or= 18 years diagnosed with neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, chemotherapy-induced peripheral neuropathic pain (pnp), or human immunodeficiency virus-related pnp. |