Welcome to dbSAP!

The Single Amino-acid Polymorphism Database (dbSAP) is a free public archive for human protein variations. dbSAP mainly contains three types of protein variations caused by: i) single nucleotide polymorphisms (SNPs), ii) mutations, and iii) post-translational modifications (PTM). The returned information with blue color and underscore is linked to another page, users can click the link to get more related information.

Search Gene Please input the HGNC gene symbol (e.g. EGFR ), the related variation information including genomic location, variation ID, reference and alternative alleles will be shown. The returned varitions are those ones with supported peptides identified by mass spectrometry data.	Search Variation Just input variation (SNP or mutations) location (e.g. chr3:121448088 or 121448088), SNP ID (such as rs147340438) or COSMIC ID (e.g. COSM231831) you will get the related gene and protein information.
Search Peptide Please input the sequence of mutated peptide (e.g. DREAAEGLGSHDR), the corresponding variant protein and variation information will be presented to you.	Search Protein Please input the protein name (Ensembl or SwissProt) (such as ENSP00000264028, IPI00410714, P04264, NP_002734), the associated variant protein and other information will be returned.