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PedAM

Pediatric Disease Annotations & Medicines




Disease vitamin b12 deficiency
Phenotype C0002892|pernicious anemia
Sentences 6
PubMedID- 24248213 vitamin b12 deficiency may result from pernicious anemia, gastric resection, intestinal malabsorption or a strict vegan diet.
PubMedID- 23028239 pernicious anemia represents 20%-50% of the causes of vitamin b12 deficiency in adults.
PubMedID- 24145274 pernicious anemia leading to vitamin b12 deficiency is another rare associated cause.
PubMedID- 23964320 Higher circulating concentrations of folate have been hypothesized to mask pernicious anemia due to vitamin b12 deficiency, cause cognitive impairment in elderly subjects, reduce the efficacy of anti-folate drugs, increase the risk of insulin resistance and obesity in children and have the potential to promote cancer [15-18].
PubMedID- 21174235 Silent initially, the gastric lesion becomes manifest in humans by the development of megaloblastic pernicious anemia arising from vitamin b12 deficiency.
PubMedID- 22242613 In spain, germany, and italy, the corresponding numbers would range from 100,000 to 200,000. in the usa, it has been estimated earlier that approximately 800,000 elderly people have undiagnosed and untreated pernicious anemia due to vitamin b12 deficiency [35].

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