PedAM
Pediatric Disease Annotations & Medicines
| Disease | vascular disease |
| Phenotype | C0028754|obesity |
| Sentences | 152 |
| PubMedID- 23545209 | Insulin resistance and subsequent hyperinsulinemia, originating from abdominal obesity, increases the risk of cerebrovascular and cardiovascular disease and all-cause mortality. |
| PubMedID- 23671778 | [4] physical and psychological problems are related to childhood obesity, including increased risk of cardiovascular disease, diabetes, hyperlipidemia, hypertension, and metabolic syndrome[9–12] as well as poor body image, self-esteem and overall well-being. |
| PubMedID- 26435566 | Other independent risk factors appear to include height, obesity, presence of cardiovascular disease, presence of severe ketoacidosis, and presence of microalbuminuria. |
| PubMedID- 23251329 | Central obesity increases the risk of cardiovascular disease. |
| PubMedID- 24164965 | Alteration in endothelial function, insulin resistance and inflammation, all risk factors for adult cardiovascular disease are associated with obesity in adolescents. |
| PubMedID- 25951943 | obesity is associated with cardiovascular disease, type 2 diabetes mellitus and some cancers [1,2]. |
| PubMedID- 25307314 | obesity is significantly associated with cardiovascular disease risk factors in 2- to 9-year-olds. |
| PubMedID- 21160602 | A diligent search for such clinical markers, namely xanthelasma, xanthoma, arcus juvenilis, acanthosis nigricans, skin tags, ear lobe crease, nicotine stains, premature graying in smokers, hyperpigmented hands in betel quid sellers, central obesity, and signs of peripheral vascular disease may prove to be a rewarding exercise in identifying asymptomatic cad in high risk individuals. |
| PubMedID- 25813485 | Medicine, prague, czech republic; inserm, umr1048, obesity research laboratory, institute of metabolic and cardiovascular diseases, 31432 toulouse, cedex 4, france; university of toulouse, umr1048, paul sabatier university, 31432 toulouse, cedex 4, france; toulouse university hospitals, department of clinical biochemistry, 31059 toulouse, cedex 9, france. |
| PubMedID- 22649461 | obesity is one of the major cardiovascular disease (cvd) risk factors and is a common health problem both in adults and in children [1]. |
| PubMedID- 20305745 | Il-6 is a well-known risk marker of cardiovascular disease associated with obesity, type 2 diabetes and myocardial infarction. |
| PubMedID- 25874887 | Background: obesity is associated with advanced cardiovascular disease. |
| PubMedID- 20010901 | As obesity is associated with cardiovascular diseases, the purpose of this study was to investigate the effect of obesity on forearm skin blood flow (fsbf) response to acetylcholine (ach), an endothelium-dependent vasodilator, in tunisian women over a wide range of body mass indices (bmis). |
| PubMedID- 21081220 | This chapter highlights recent advances in both clinical investigations and animal studies promoting the understanding of the roles of adiponectin and a-fabp in the modulation of vascular function, and discusses the possibilities of using these two adipokines as therapeutic targets to design new drugs for preventing vascular disease associated with obesity and diabetes. |
| PubMedID- 23497440 | In addition, epidemiological and population studies have established a direct correlation between obesity and development of cardiovascular disease [13]. |
| PubMedID- 24319476 | obesity increases the risk of cardiovascular diseases and diabetes mellitus type 2, comorbidities often detected in metabolic syndrome [1], and visceral fat is linked to metabolic disorders and increased risk of cardiovascular disease [2, 3]. |
| PubMedID- 22073323 | Waist circumference reflects central obesity and risk of cardiovascular disease. |
| PubMedID- 20470376 | The study included 97 japanese high-risk outpatients for cardiovascular disease with abdominal obesity (40% female) in the obesity/metabolic syndrome clinic, department of cardioangiology, kitasato university hospital. |
| PubMedID- 21994528 | An increased level of nonesterified ffa has been suggested as a possible mediator of insulin resistance and cardiovascular disease associated with obesity [15,16]. |
| PubMedID- 23884889 | obesity increases the risk of cardiovascular disease, premature death, insulin resistance, t2d, and many types of cancer (32,33). |
| PubMedID- 21087312 | Because these benefits occurred in youth, before advanced metabolic and vascular complications, melatonin might help to prevent cardiovascular disease associated with obesity and dyslipidemia. |
| PubMedID- 22849607 | It is worth noting that exercise interventions that improve endothelial cell function are critical for defining effective approaches to prevent atherosclerotic cardiovascular disease associated with obesity, particularly in at-risk individuals. |
| PubMedID- 23349535 | Available evidence suggests that impaired vascular insulin sensitivity may be an early, perhaps principal, defect of vascular function and contributor to the pathogenesis of vascular disease in persons with obesity, hypertension, and t2d. |
| PubMedID- 22586401 | In individuals with uncomplicated obesity (without the presence of cardiovascular disease), an increase in body mass index (45 ± 5 vs. 21 ± 2) is associated with an increase in left ventricular mass (irrespective of normalized to height or body surface area), and end-diastolic volume (unadjusted or indexed to height; rider et al., 2011). |
| PubMedID- 21651756 | obesity may lead to cardiovascular disease, type 2 diabetes, and several cancers. |
| PubMedID- 24473057 | It is known that obesity is associated with cardiovascular disease, metabolic disorders, degenerative joint disorders, and decreased health-related quality of life (hrqol). |
| PubMedID- 21756310 | Except for the established risk factors [age, gender, family history of cardiovascular disease, smoking, obesity, dyslipidemia and diabetes mellitus (dm)], presence of subclinical target organ damage (tod) (left ventricular hypertrophy, carotid atheromatosis and renal impairment) has an important role in the treatment of hypertensive subjects and the prevention of cardiovascular disease [2,3]. |
| PubMedID- 23204527 | obesity is a predictor of diabetes and cardiovascular disease. |
| PubMedID- 24702860 | Oxidative stress is also a hallmark of obesity-related dyslipidaemia leading to cardiovascular diseases by decreasing aortic flow and left ventricular function, while increasing the extent of myocardial necrosis under experimental settings [4]. |
| PubMedID- 24550188 | obesity is associated with vascular diseases that are often attributed to vascular oxidative stress. |
| PubMedID- 22272346 | We showed that irak3 in monocytes is downregulated in obesity before the development of t2dm and cardiovascular disease and that its expression increased with weight loss. |
| PubMedID- 23471217 | Recherche 1048, obesity research laboratory, institute of metabolic and cardiovascular diseases, 31432 toulouse cedex 4, france. |
| PubMedID- 21513515 | Background: insulin resistance and obesity are strongly associated with systemic cardiovascular diseases. |
| PubMedID- 23700517 | obesity increases the risk of diabetes, cardiovascular diseases and cancer. |
| PubMedID- 24526749 | Given the association of obesity with cardiovascular disease, it could be speculated that obese individuals would have adverse outcomes after a cardiovascular event compared to those with normal body mass index (bmi). |
| PubMedID- 25864996 | Inflammation and obesity are associated with cardiovascular disease and arrhythmogenesis, but little is known about the relationship between epicardial fat and pr-interval prolongation. |
| PubMedID- 22517513 | Aim of the present study was to evaluate the prevalence and the vascular risk of the combination of obesity and hypertension in patients with vascular diseases. |
| PubMedID- 22701480 | Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and increased risk of cardiovascular disease associated with obesity [43]. |
| PubMedID- 24142315 | obesity is closely associated with cardiovascular diseases, since excess body fat maypredispose the individual to multiple comorbidities, such as hypertension anddyslipidemia(1,2). |
| PubMedID- 26064110 | Hence, further studies need to be done on leptin and specifically leptin resistance, in order to better understand leptin's function in obesity and promotion of cardiovascular diseases. |
| PubMedID- 24558974 | obesity, an independent predictor of cardiovascular disease (cvd)[6,7] has been found to be associated with abnormal imt. |
| PubMedID- 26322161 | This has been accompanied by an increased prevalence of obesity, a condition associated with diabetes, hypertension, cardiovascular disease, asthma and cancer. |
| PubMedID- 22774383 | Background: obesity is often associated with high cardiovascular disease risk factors. |
| PubMedID- 25925588 | Secondary major health risks, such as but not limited to hypertension, insulin resistance, type 2 diabetes (t2d) and cardiovascular diseases are highly associated with obesity and are seen as well in increasing numbers of adults worldwide [2,3]. |
| PubMedID- 26467124 | Recently, similar, although fewer, observations confirm the occurrence of the obesity paradox in patients with acute cerebrovascular diseases. |
| PubMedID- 24517399 | Emerging studies have revealed that visceral white adipocytes can act as an active endocrine tissue, secreting adipocytokines that play a key role in the relationship between obesity and the development of cardiovascular disease[41]. |
| PubMedID- 25590576 | obesity research laboratory, institute of metabolic and cardiovascular diseases (i2mc), toulouse, france; university of toulouse, umr1048, paul sabatier university, toulouse, france; toulouse university hospitals, departments of clinical biochemistry and nutrition, toulouse, france. |
| PubMedID- 24983748 | obesity research laboratory, institute of metabolic and cardiovascular diseases (i2mc), toulouse, france; university of toulouse, umr1048, paul sabatier university, toulouse, france; toulouse university hospitals, departments of clinical biochemistry, toulouse, france. |
| PubMedID- 25648082 | Significant factors commonly reported to be associated with weight loss have includedextreme obesity, a history of repeated attempts, cardiovascular disease risk factors, femalegender, level of education, self-efficacy, physical self-image, income, employment andmarital status10, 11, 12, 13). |
| PubMedID- 23272007 | Medical history covariates were included in the model to account for the variance of common cardiovascular disease factors associated with obesity that influence cognitive function. |