PedAM
Pediatric Disease Annotations & Medicines
| Disease | vascular disease |
| Phenotype | C0018099|gout |
| Sentences | 9 |
| PubMedID- 25165032 | Cox proportional hazard modelling was used to produce both unadjusted and adjusted hrs, estimating the excess risk of the various forms of vascular disease, associated with gout,30 using robust ses to adjust for any clustering induced by matching.31 the validity of the proportional hazards assumption was tested using schoenfeld residuals and stata's own diagnostic test. |
| PubMedID- 25594854 | The mechanisms that link high serum uric acid levels and gout with cardiovascular diseases are multifactorial, implicating low-grade systemic inflammation and xanthine oxidase activity as well as the deleterious effect of hyperuricaemia itself. |
| PubMedID- 25399391 | Conclusion: the direct and indirect costs-of-illness of gout are primarily associated with cardiovascular disease, functional limitations, and female sex. |
| PubMedID- 26515421 | Recent epidemiological studies have indicated that hyperuricemia with or without gout increases the risk of cardiovascular diseases and mortality [1–6]. |
| PubMedID- 23533601 | The association of gout with cardiovascular disease, first described in the 19th century was thought to be an association, rather than a cause, of cardiovascular disease. |
| PubMedID- 22676161 | Given the recent dramatic increase in the incidence of gout and hyperuricemia associated with cardiovascular diseases and metabolic syndrome [13], it is highly desirable to introduce a safe and economic way to reverse these trends. |
| PubMedID- 21886828 | High serum uric acid (sua) levels can lead to gout and is associated with cardiovascular diseases and diabetes [1], whereas low sua levels may be associated with multiple sclerosis [2], [3]. |
| PubMedID- 26504360 | Therefore, gout is positively associated with cardiovascular disease risk and mortality. |
| PubMedID- 23947924 | gout increases the risk of cardiovascular disease, even in young people and those without cardiovascular risk factors [5]. |
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