PedAM
Pediatric Disease Annotations & Medicines
| Disease | vascular disease |
| Phenotype | C0002965|unstable angina |
| Sentences | 1 |
| PubMedID- 24323316 | Despite this, the mutation has been associated with decreased cardiovascular risk40 and circulating levels of ccl5 are increased in cardiovascular disease.41,42 in patients with unstable angina,41 ccl5 is detectable in the nanomolar range, and in a study of hypertensives, those individuals with the highest plasma levels of ccl4 had a higher risk of stroke and cardiovascular events with the authors concluding that ccl4 contributed to the development of atherosclerosis.43 the plasma levels of ccl4 detected in these hypertensives was 44–336 pg ml−1 which based on the affinity for ccl4 determined in our radioligand binding assay would produce a level of ccr5 receptor occupancy of between 84 and 97%. |
Page: 1