PedAM
Pediatric Disease Annotations & Medicines
| Disease | uterine sarcoma |
| Phenotype | C1261473|sarcoma |
| Sentences | 1 |
| PubMedID- 25316466 | However, there are still some centers that treat this as sarcoma.4 uterine sarcomas occur primarily in women who are 40-60 years old.5,6 a history of pelvic irradiation was also considered a risk factor in 5-10% of cases.7 compared with the more common types of endometrial cancer, women with uterine sarcoma have a poor prognosis due to the aggressiveness of the disease.5-7 the most frequent prognostic factors include the stage, histological subtype, grade, lymph vascular invasion, and menopausal status.8-10 standard treatment of early stage patients are hysterectomy and surgical staging, and approximately half of these patients develop recurrent disease.10 post-operative radiotherapy reduces local recurrence and improves local disease but does not affect the overall survival.11,12 adjuvant chemotherapy with a single agent, isofosamide or doxorubicin, has been used,11 and combination chemotherapy (which did not show any superiority) has non-proven value over a single agent.13 due to its rarity, heterogeneity, and aggressiveness, there is no consensus regarding the optional therapeutic approaches with considerable variation in the type of surgery and choice of adjuvant treatment. |
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