PedAM
Pediatric Disease Annotations & Medicines
| Disease | thrombocytosis |
| Phenotype | C0040053|thrombosis |
| Sentences | 11 |
| PubMedID- 22768743 | The paper describes two clinical cases of essential thrombocythemia (et) complicated by thrombosis in parturients. |
| PubMedID- 25878908 | In view of thrombocytosis with splanchnic thrombosis, sequencing for jak2 was done which showed homozygous jak2v617f mutation. |
| PubMedID- 23788909 | Contrary to the almost threefold higher risk of venous thrombosis in patients with thrombocytosis diagnosed before commencement of treatment, confirmed in a few studies [7, 8], in most reports – though they are not numerous – thrombocytosis after administration of gemcitabine was temporary and passed without complications. |
| PubMedID- 20663173 | We report an aortic thrombosis case with myeloproliferative thrombocytosis treated by medical management. |
| PubMedID- 21042569 | Based on 2 phase i/ii trials,74,75 a parallel placebo-controlled phase iii trial,76 and an open-label study,77 the most important observations regarding the use of romiplostim are the following: (i) romiplostim produces a durable platelet response in both previously splenectomized (38%) and nonsplenectomized patients (56%); (ii) adult patients responding to romiplostim experience an improvement of health-related quality of life;78 (iii) side effects are very unusual, mild to moderate headache being the most frequent (39%), although transient worsening of thrombocytopenia during the post-treatment period (vaginal hemorrhage) and deep venous thrombosis owing to secondary thrombocytosis have been occasionally reported; (iv) antibodies against endogenous tpo or romiplostim have not been reported. |
| PubMedID- 19582452 | Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous jak2 v617f mutation. |
| PubMedID- 21142409 | Cerebral venous thrombosis due to essential thrombocythemia and worsened by heparin-induced thrombocytopenia and thrombosis. |
| PubMedID- 25345874 | However, even in adults, thrombocytosis is not associated with thrombosis [13,14,22], and the transient nature of the thrombocytosis renders it a minor issue. |
| PubMedID- 25223529 | The current widely accepted stratification defined by age and previous thrombosis in patients with essential thrombocythemia (et) probably deserves deeper analysis. |
| PubMedID- 24709317 | Deep vein thrombosis occurs in 30% of patients with essential thrombocythemia, but rarely at initial diagnosis. |
| PubMedID- 20623009 | This drug is often used to supplement phlebotomy for patients with polycythemia vera (pv; [2]) and to reduce significantly the incidence of recurrent thrombosis in patients with essential thrombocythemia who are at high risk [3]. |
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