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PedAM

Pediatric Disease Annotations & Medicines




Disease thrombocytosis
Phenotype C0027022|myeloproliferative neoplasms
Sentences 4
PubMedID- 22381681 This study provides new insights into the mechanisms underlying lbh589-induced thrombocytopenia and provides a rationale for using tubulin as a target for selective histone deacetylase inhibitor therapies to treat thrombocytosis in patients with myeloproliferative neoplasms.
PubMedID- 22084665 The “classic” myeloproliferative neoplasms (mpns), comprised of essential thrombocythemia (et), chronic myeloid leukemia (cml), polycythemia vera (pv), and primary myelofibrosis (pmf) [41] are the most common clonal processes associated with thrombocytosis.
PubMedID- 24114627 Classical myeloproliferative neoplasms (mpns) are composed of essential thrombocythemia (et), polycythemia vera (pv) and myelofibrosis (mf), the etiology of which is largely unknown.
PubMedID- 22170483 The bcr/abl-negative myeloproliferative neoplasms (mpns) of essential thrombocythemia, polycythemia vera, and primary myelofibrosis, over the natural course of their disease, have an increasing predisposition to transform to overt acute myeloid leukemia (aml)-most appropriately referred to as mpn-blast phase (mpn-bp).

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