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PedAM

Pediatric Disease Annotations & Medicines




Disease thrombocytopenia
Phenotype C0040053|thrombosis
Sentences 42
PubMedID- 23690810 Background: several studies have emphasized thrombosis associated with thrombocytopenia as a potentially fatal complication of heparin.
PubMedID- 19903167 A portion of these patients will have significant thrombotic complications referred to as hitt (heparin-induced thrombocytopenia with thrombosis).
PubMedID- 23832870 Efficacy and safety of off-label use of fondaparinux in the management of heparin-induced thrombocytopenia with thrombosis in an elderly woman.
PubMedID- 23533431 Venous and arterial thrombosis associated with thrombocytopenia during heparin treatment must be considered hit whatever the biological test results are.
PubMedID- 26556106 Hit is considered a clinico-pathological syndrome for which the diagnosis is based on thrombocytopenia with or without thrombosis and the detection of heparin-dependent antibodies [9].
PubMedID- 22970706 Argatroban is an intravenous direct thrombin inhibitor currently indicated for the prophylaxis and treatment of thrombosis associated with heparin-induced thrombocytopenia (hit) and for patients at risk of hit undergoing percutaneous coronary intervention (pci).
PubMedID- 21297217 Acute stent thrombosis associated with heparin-induced thrombocytopenia and abciximab-induced profound thrombocytopenia.
PubMedID- 24733133 Purpose: the case of an oncology patient who developed heparin-induced thrombocytopenia with thrombosis (hitt) and was treated with argatroban plus catheter-directed thrombolysis (cdt) with alteplase is presented.
PubMedID- 20460351 Heparin-induced thrombocytopenia with thrombosis (hitt) is the most severe side effect of heparin administration.
PubMedID- 21593020 Heparin-induced thrombocytopenia with thrombosis (hitt) is a complication of heparin treatment caused by heparin platelet factor 4 (hpf-4) antibodies, leading to platelet activation and hypercoagulability.
PubMedID- 26550230 This report evaluates the efficiency and safety of catheter-directed thrombolysis (cdt) using tissue plasminogen activator (tpa) and argatroban for the treatment of ivc filter thrombosis complicated by heparin-induced thrombocytopenia (hit).
PubMedID- 22893109 We report a case of heparin-induced thrombocytopenia with thrombosis type 2 (hitt 2) that was first complicated by intracerebral hemorrhage (ich) and later by deep venous thrombosis (dvt).
PubMedID- 24766968 thrombosis was attributed to heparin-induced thrombocytopenia if it occurred within 1 week of the positive serologic test.
PubMedID- 20504888 Serious acute coronary thrombosis associated with heparin-induced thrombocytopenia in off-pump coronary artery bypass grafting.
PubMedID- 20807654 Heparin-induced thrombocytopenia (hit) with thrombosis is the most severe side effect of heparin administration.
PubMedID- 20088924 In congenital or acquired deficiency it is actively involved in the pathophysiology of thrombotic thrombocytopenic purpura (ttp), a rare but life threatening disease characterized by microangiopathic haemolytic anaemia and consumptive thrombocytopenia leading to disseminated microvascular thrombosis and variable signs and symptoms of organ ischemia and damage.
PubMedID- 25169901 Progressive, fatal thrombosis associated with heparin-induced thrombocytopenia after cardiac surgery despite "therapeutic" anticoagulation with argatroban: potential role for ptt and act confounding.
PubMedID- 22415004 In view of the interesting evidence that suggests a potential role for bacteria in triggering disorders that have an autoimmune component—e.g., the antiphospholipid syndrome (20) and heparin-induced thrombocytopenia with thrombosis (21)—we wondered whether bacteria might also bind anxa5.
PubMedID- 25022565 Background: guidelines are discordant concerning management of patients having thrombocytopenia with cancer-associated thrombosis (cat).
PubMedID- 22039845 This article will review the evidence-based management of heparin induced thrombocytopenia with thrombosis, anti-phospholipid antibody syndrome and catastrophic anti-phospholipid antibody syndrome, thrombohemorrhagic manifestations of philadelphia chromosome-negative chronic myeloproliferative neoplasms including polycythemia vera, essential thrombocythemia and primary myelofibrosis, as well as paroxysmal nocturnal hemoglobinuria.
PubMedID- 21633576 [11] this overall process results in a potentially dangerous procoagulant hypercoagulable state, and a significant increased risk of thrombosis is seen in patients with thrombocytopenia (89%) in comparison to those with a normal platelet count (19%).
PubMedID- 21083469 Argatroban is a synthetic, small-molecule direct thrombin inhibitor that is approved in the usa, the eu and japan for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (hit), and for anticoagulation of hit patients undergoing pci.
PubMedID- 22382479 Purpose: a case report describing high-dose argatroban for the treatment of heparin-induced thrombocytopenia (hit) with thrombosis and associated considerations in interpreting laboratory monitoring data are presented.
PubMedID- 22244722 Thrombotic thrombocytopenic purpura (ttp) is a rare but severe disease characterized by mechanical hemolytic anemia and consumptive thrombocytopenia leading to disseminated microvascular thrombosis that causes signs and symptoms of organ ischemia and functional damage.
PubMedID- 26062524 Delayed-onset heparin-induced thrombocytopenia without thrombosis in a patient receiving postoperative thromboprophylaxis with rivaroxaban.
PubMedID- 26266247 Drug-immune thrombocytopenia with thrombosis versus heparin-induced thrombocytopenia: a critical clinical controversy.
PubMedID- 25018921 Its main clinical complication is the development of thrombocytopenia with or without thrombosis.581 in patients with aki undergoing crrt, the diagnosis should therefore also be suspected in patients with repeated premature filter clotting.630 the likelihood of having hit can be predicted by the so-called 4 t score, that includes the degree of thrombocytopenia, the timing of onset of the fall in platelet count, the presence of thrombosis or acute systemic symptoms, and the presence of other etiologies of thrombocytopenia.631 if hit is likely, all heparins have to be stopped, including any “heparin lock” solutions for dialysis or other catheters.
PubMedID- 25607417 Thrombotic thrombocytopenic purpura (ttp) is a rare but severe disease characterized by mechanical hemolytic anemia and consumptive thrombocytopenia leading to disseminated microvascular thrombosis that causes signs and symptoms of organ ischemia and functional damage.
PubMedID- 22519199 Heparin-induced thrombocytopenia with iliacofemoropopliteal thrombosis in a patient operated for colorectal carcinoma liver metastases.
PubMedID- 22627957 thrombosis due to heparin-induced thrombocytopenia (hit) occurred during pci, which was completed after switching to argatroban based on the possible hit.
PubMedID- 23130099 Vwf-dependent arteriolar platelet thrombosis is the hallmark of thrombotic thrombocytopenia purpura (ttp) and the hemolytic-uremic syndrome (hus).
PubMedID- 24363883 However, higher incidence of portal vein thrombosis reported with eltrombopag in thrombocytopenia secondary to chronic liver disease.
PubMedID- 23847271 Nsbbs-induced adverse events include lightheadedness, fatigue and shortness of breath, while the anticoagulant-induced adverse events include bleeding, thrombocytopenia with or without thrombosis, osteoporosis, skin necrosis, alopecia, hypersensitivity reactions and hypoaldosteronism.
PubMedID- 23419837 Refractory heparin induced thrombocytopenia with thrombosis (hitt) treated with therapeutic plasma exchange and rituximab as adjuvant therapy.
PubMedID- 25980337 He had venous thrombosis due to heparin-induced thrombocytopenia and a right-to-left shunt, likely due to a trans-septal puncture during catheter ablation.
PubMedID- 24300023 We describe one such case of rapid-onset, heparin-induced thrombocytopenia with thrombosis that developed in the setting of catheter-directed ablation of atrial fibrillation, several months after a brief exposure to low-molecular-weight heparin.
PubMedID- 24405989 She was found to have severe thrombocytopenia with deep vein thrombosis of left lower limb and arterial thrombosis of the right anterior and middle cerebral arteries.
PubMedID- 21701111 The present case illustrates the possibility of heparin-induced thrombocytopenia associated with catheter-related thrombosis in neurosurgery.
PubMedID- 24439323 The indications were (1) impaired cardiac function (n = 13); (2) no other prospect for avf or patient refused prosthetic graft implantation (n = 5); (3) severe upper extremity arterial disease or ischemic steal syndrome requiring avf closure (n = 3); (4) venous hypertension with central vein occlusion (n = 2); and (5) repeated avf thrombosis due to heparin-induced thrombocytopenia (n = 1).
PubMedID- 21095367 To our knowledge this is the first report of successful thrombolysis of pulmonary thrombosis due to heparin-induced thrombocytopenia after pulmonary endarterectomy.
PubMedID- 24299288 [heparin-induced thrombocytopenia in a patient with acute thrombosis, acute aortic dissection and acute lower limb ischaemia].
PubMedID- 24382968 Although we could not establish a histological diagnosis of vascular thrombosis due to severe thrombocytopenia, the presence of microangiopathic hemolytic anemia and markedly elevated fibrin degradation products including d-dimer indicated vascular thrombosis.

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