PedAM
Pediatric Disease Annotations & Medicines
| Disease | thrombocytopenia |
| Phenotype | C0002871|anemia |
| Sentences | 76 |
| PubMedID- 22929300 | 59. thrombocytopenia associated with mechanical hemolytic anemia should suggest tma, even in the absence of organ failure (strong agreement). |
| PubMedID- 23943710 | A congenital or acquired deficiency of adamts-13 can result in accumulation of the ultralarge vwf multimers leading to microangiopathic thromboses and severe thrombocytopenia with resultant hemolytic anemia and thrombotic sequelae.6 in the rare familial forms of ttp, mutations of the adamts-13 gene can be found resulting in significant risk of ttp in pregnancy in affected women.6 acquired ttp is postulated to be secondary to viral infections that trigger production of antibodies targeted against adamts-13.7 women with acquired ttp also have a high risk of recurrence in a subsequent pregnancy.6 it has been proposed that specific proteins found in the placental circulation serve as antigens that trigger maternal antibody production against adamts-13. |
| PubMedID- 21559455 | The criteria for hus diagnosis were microangiopathic hemolytic anemia with schizocytes, thrombocytopenia (platelet count <150×109/l) and acute renal failure (serum creatinine level higher than the normal values considering the age of the patient). |
| PubMedID- 26511208 | A complete blood count revealed bicytopenia (normocytic-normochromic anemia with thrombocytopenia). |
| PubMedID- 23758712 | Hemangioma-thrombocytopenia syndrome associated with microangiopathic hemolytic anemia has been documented in children. |
| PubMedID- 24719674 | Her laboratory profile (6 months prior to admission) revealed anemia with hemoglobin of 11.4 g/dl and thrombocytopenia, with a platelet count of 87×103/ul. |
| PubMedID- 21772952 | Evans syndrome (es) is an autoimmune disorder characterized by thrombocytopenia and/or neutropenia associated with hemolytic anemia (aha).1–3 it is a potentially life-threatening condition that may be associated with other underlying autoimmune or lymph-proliferative disorders.4 standard treatment consists of transfusions, corticosteroids and immunoglobulins (ivig); second-line treatment in es evolved over the last decade, and includes at present anti-cd20 rituximab, vincristine, alkalizing agents, mycophenolate mofetil (mmf) or cyclosporine (cya).5–6,8–14 long-term remissions induced by splenectomy are less frequent than in uncomplicated immune thrombocytopenia purpura (itp). |
| PubMedID- 22606437 | Laboratory tests revealed anemia with a hematocrit of 37%, severe thrombocytopenia with 44000 platelets, coagulopathy with a prolonged prothrombin time of 20.3 seconds and elevated liver tests with total bilirubin of 4 mg/dl, ast of 59 international units, alt of 36 international units, and elevated alkaline phosphatase of 182. autoimmune workup was negative, alpha-1-antitrypsin and serum ceruloplasmin levels were within normal limits and 24-hour urine copper was above the normal limit. |
| PubMedID- 24987262 | Esr and crp were elevated; his white cell count was 16,000, had anemia with thrombocytopenia and a positive aso titer. |
| PubMedID- 21597288 | Grade 3 and 4 toxicities included anemia (20.5% of patients), thrombocytopenia (2.3%), neutropenia (10.3%), aspartate transaminase increase (10.3%), alanine transaminase increase (5.1%) and emesis (5.1%). |
| PubMedID- 23842487 | Background: hemolytic anemia with thrombocytopenia and schistocytosis is suggestive of thrombotic thrombocytopenic purpura (ttp). |
| PubMedID- 21377915 | A 79 year-old man was referred to the hematology unit of a hospital because of anemia with thrombocytopenia and hepatosplenomegaly. |
| PubMedID- 24490094 | There are many reported cases of hemolytic anemia with or without thrombocytopenia in gastric cancer. |
| PubMedID- 19802631 | Investigations revealed anemia (hemoglobin of 8.9 g/dl), thrombocytopenia (platelet count of 21,000 cells per microliter), and positive hiv antibody (perinatal transmission). |
| PubMedID- 21776377 | On admission, tma, seronegative autoimmune hemolytic anemia with thrombocytopenia (evans syndrome), caps, and dic were considered as possible candidates for her thrombocytopenia with hemolytic anemia. |
| PubMedID- 25653716 | Despite these facts our present findings might give some first clues to better understand how chromosomal and genomic aberrations are related to chronic thrombocytopenia with moderate anemia and no clear signs of mds. |
| PubMedID- 22567017 | Laboratory examination was remarkable for anemia (hemoglobin of 5.8 mg/dl) and thrombocytopenia (platelets less than 10,000/mm3) with lactate dehydrogenase of 744 u/l. |
| PubMedID- 22953078 | The initial laboratory testing carried out in front of this mechanical anemia with thrombocytopenia unresponsive to transfusions showed an increased ldh 863 ui/l (2 times normal), serum potassium to 4.2 mmol/l (3–5 mmol/l), collapsed serum haptoglobin (0.53 g/l), hyperbilirubinemia (25 mg/l), the direct coombs test (the test in antiglobinul) negative, proteinuria 900 mg/24 h, and renal function normal with serum creatinine at 5 mg/l (7–14 mg/l). |
| PubMedID- 23559773 | Laboratory investigations showed anemia with hemoglobin of 4.7 gm% and thrombocytopenia with a platelet count of 29,000/cumm. |
| PubMedID- 25816809 | Ahus was suspected based on anemia with schistocytes, thrombocytopenia, low c3, and acute kidney injury requiring peritoneal dialysis. |
| PubMedID- 24800022 | Three patients with cholelithiasis died, one because of end stage renal disease due to polycystic kidney disease (pkd), one because of renal failure and hemorrhage complicating thrombocytopenia associated with fanconi anemia, and the last one because of metabolic disease (mitochondrial type). |
| PubMedID- 24833969 | [40] found a non-regenerative anemia, with neutropenia, thrombocytopenia and normallymphocyte count. |
| PubMedID- 21295897 | We report the first case to our knowledge of a patient who developed an acute decrease in kidney function, nonimmune microangiopathic hemolytic anemia with schistocytes, and thrombocytopenia after 4 intravitreal injections of ranibizumab. |
| PubMedID- 23646270 | Due to persistent symptoms, further tests were performed that revealed anemia (hgb of 7.8 mg/dl) and thrombocytopenia (platelets of 15 × 103/mm3). |
| PubMedID- 22493563 | The resolution of severe symptomatic anemia along with thrombocytopenia following iron supplementation strengthens the hypothesis that iron therapy plays an important role in improving iron deficiency anemia associated thrombocytopenia. |
| PubMedID- 23398940 | This thrombocytopenia, together with the lower anemia and lower general inflammation, may explain the lower death rate observed in treated chickens. |
| PubMedID- 22760926 | This resulted in a partial response 3 months later: persistent transfusion-dependent anemia without signs of intravascular hemolysis, thrombocytopenia, and a normal leucocyte count. |
| PubMedID- 26347828 | Predictors of a poor outcome include age older than 30 years, the presence of disseminated intravascular coagulation, elevated ferritin level, and anemia with accompanying thrombocytopenia [5]. |
| PubMedID- 20399168 | Hemolytic anemia with schistocytes, thrombocytopenia without evidence of disseminated intravascular coagulation, and renal failure are consistently found. |
| PubMedID- 24279773 | Leukocytosis (10,900/μl), anemia (hemoglobin level of 10.6 g/dl), and thrombocytopenia (4.5 × 104/μl) were present, and immature granulocytes with cytoplasmic vacuolation and dohle bodies were identified in the peripheral blood. |
| PubMedID- 21151550 | Peripheral blood smear examination revealed schistocytes and thrombocytopenia consistent with microangiopathic hemolytic anemia (fig. |
| PubMedID- 22374533 | It is important to suspect ttp when hemolytic anemia with thrombocytopenia is observed, and to check the activity and antigen of adamts13 immediately for the diagnosis. |
| PubMedID- 23827373 | Hemolytic and uremic syndrome (hus) is a classical form of thrombotic microangiopathies characterized by the association of hemolytic anemia with schizocytes, thrombocytopenia, and acute renal failure. |
| PubMedID- 22015492 | It is well known that cobalamin deficiency may also cause thrombocytopenia together with anemia and leukopenia in children. |
| PubMedID- 26082779 | Ahus is characterized by a triad of hemolytic anemia due to fragmented erythrocytes, thrombocytopenia, and acute renal failure. |
| PubMedID- 20418784 | In multivariate analysis, only anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia were the independent risk factors (relative risk 3.77; confidence interval, 1.7-8.4; p<0.0011 and relative risk 2.59; confidence interval, 1.24-5.4; p<0.0112). |
| PubMedID- 22570800 | Hematological abnormalities such as chronic disease anemia, leucopenia with lymphopenia, thrombocytopenia or, more rarely, pancytopenia, are frequently described [6]. |
| PubMedID- 24649446 | The common co-morbid diseases at the onset of seizures were hematological disorders (pancytopenia 8, anemia 2, anemia with thrombocytopenia 2) and sepsis (n=8). |
| PubMedID- 20413929 | [2] severe anemia, when associated with thrombocytopenia can frequently result in ocular manifestations. |
| PubMedID- 26405482 | Laboratory data revealed a severe renal insufficiency with a creatinine of 48.5mg/l, normocytic anemia to 8.1g/dl associated with thrombocytopenia 80,000 / mm3 and positive anti-nuclear and anti-scl 70 antibodies. |
| PubMedID- 24106450 | Normochromic-normocytic anemia ormacrocytic anemia with thrombocytopenia may occur. |
| PubMedID- 26448695 | A complete blood count (cbc) revealed anemia (hemoglobin of 9.3 g/dl), thrombocytopenia (platelet count of 28 × 103/μl), and leukocytosis (white blood cell count (wbc) of 11.2 × 103/μl). |
| PubMedID- 20359326 | This disease causes hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and nonfocal neurologic findings, and decreased renal function. |
| PubMedID- 26351594 | He was seen in the infectious disease clinic, where he was noted to have worsening anemia (hgb of 7.2 g/dl) and thrombocytopenia (42,000 per microliter), with ldh elevation of 1661 and normal uric acid. |
| PubMedID- 26043771 | Mild anemia (11.6 % of the dogs), thrombocytopenia (11.6 %), and rouleaux (9.3 %) were the most significant findings in the analyzed smears. |
| PubMedID- 23602056 | thrombocytopenia together with microangiopathic hemolytic anemia is mandatory for the diagnosis of ttp and if these two criteria met in a patient, tpe should be performed immediately. |
| PubMedID- 20056203 | Result(s): both patients developed a very rare complication after surgery of severe thrombocytopenia with microangiopathic hemolytic anemia leading to acute renal failure. |
| PubMedID- 24413066 | thrombocytopenia with coexistent anemia was found in just one case (4%), splenomegaly in two (8%) and lymphadenopathy also in only one (4%). |
| PubMedID- 25821808 | Eryptosis is triggered by hemolytic uremic syndrome (hus), characterized by hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and acute renal failure [198]. |
| PubMedID- 25512714 | The exact mechanism of thrombocytopenia occurring with severe anemia in menorrhagic patients is not fully understood. |
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