PedAM
Pediatric Disease Annotations & Medicines
| Disease | thalassemia |
| Phenotype | C0024530|malaria |
| Sentences | 5 |
| PubMedID- 23853772 | The protection of α+-thalassemia against malaria might be due to higher susceptibility of homozygotes to malaria in early life that immunize these individuals and make them resistance to malaria later [7]. |
| PubMedID- 22096530 | Furthermore, in malaria, alleles associated with sickle-cell anemia, thalassemias, and glucose-6-phosphate dehydrogenase deficiency confer protective effects, whereas polymorphisms in the tnf-α gene have been linked to increased risk of cerebral malaria (cm) [13]. |
| PubMedID- 22133230 | Recent studies in kenya and ghana have shown that individuals who inherit two malaria-protective genetic disorders of haemoglobin-alpha(+) thalassaemia and sickle cell trait-experience a much lower level of malaria protection than those who inherit sickle cell trait alone. |
| PubMedID- 25915902 | In a conclusion, a high frequency of alleles such as g6pd deficiency, hbs, hbc and α-thalassemia associated with malaria resistance were present on bioko island. |
| PubMedID- 26174819 | Interestingly, it is of note for the coexistence of malaria with only α-thalassemia-2 but not α-thalassemia-1, the commonly found thalassemia type in southeast asia. |
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