PedAM

Pediatric Disease Annotations & Medicines

Disease	thalassemia
Phenotype	C0002871\|anemia
Sentences	41
PubMedID- 24639300	In multivariable analysis, homozygous alpha(+)-thalassemia remained associated with anemia (adjusted odds ratio [aor] = 1.8, p = 0.004) but not with low rbp (aor = 0.6, p = 0.065).
PubMedID- 26097845	The ivsi-6 mutation leads to anemia associated with a β-thalassemia intermedia phenotype.
PubMedID- 22065975	Our sickle cell anemia patients without an α-thalassemia genotype had lower mean hemoglobin, mcv, mch, hct, and mchc, and these parameters were improved in patients with α-deletions.
PubMedID- 18955271	The anemia associated with thalassemia may be moderate to severe depending on the gene mutations involved.
PubMedID- 24348256	Dulinska et al., demonstrated that the young's modulus in erythrocytes from patients with hemolytic anemia due to hereditary spherocytosis, thalassemia, or glucose-6-phophate dehydrogenase deficiency is 1.5 to 3.5-fold greater than the young's modulus of normal erythrocytes [48].
PubMedID- 25429463	The ineffective erythropoiesis and hemolysis causes the anemia, characteristic of patients with β-thalassemia [7].
PubMedID- 20712767	The thalassemias, together with sickle cell anemia and its variants, are by far the most common monogenic diseases.
PubMedID- 25002927	It is suggested that hsv infection can aggravate the severity of anemia in patients with beta thalassemia by immune mechanisms.
PubMedID- 23944358	anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency.
PubMedID- 21444028	The hemoglobinopathies, sickle cell disease and thalassemia, represent diverse causes of anemia of pregnancy, requiring specialized care.
PubMedID- 19562358	This reference range may be a useful non-invasive tool in risk assessment for fetal anemia, especially due to homozygous alpha-thalassemia-1 or fetal isoimmunization.
PubMedID- 20585360	Severe iron deficiency anemia without thalassemia was noted (hemoglobin: 8.8 g/dl, rbc: 4.18 million/ul, mcv: 68.2 fl; serum iron: 7 mg/dl, ferritin: 4 ng/ml, uibc: 525 mg/dl) with regards to the microcytic anemia.
PubMedID- 24130436	In contrast, the frequency of alpha-thalassemia carriers in patients with microcytic anemia was 25.8%, significantly higher (p < 0.01) than that observed in the sample as a whole and in afro-descendants and euro-descendants.
PubMedID- 24575268	Homozygous β-thalassemia usually presents with severe anemia while δβ-thalassemia, even in homozygous patients, shows mild anemia or are in compensated hemolytic process.
PubMedID- 26504885	She had chronic, mild microcytic anemia in keeping with beta-thalassemia trait.
PubMedID- 23049400	Due to the different pathophysiology of anemia in thalassemia and sickle cell disease, there are significant differences in the pathophysiology of iron overload and iron-related complications in these disorders.
PubMedID- 21031060	[5] our study concludes that most of the cases belong to sickle anemia with b thalassaemia (45.71%) closely following the sickle cell trait (20%).
PubMedID- 25356075	In general, a heterozygote for thalassemia is diagnosed with a mild anemia (hemoglobin a level 1 or 2 g below normal range), low mean cell volume, low mean corpuscular hemoglobin, elevated hemoglobin a2, and normal or elevated hemoglobin f. during pregnancy, women with thalassemia minor will often show more significant anemia, which is often most prominent during the latter half of the second trimester and early third trimester (4-7).
PubMedID- 24476732	Chronic blood transfusion is the only treatment for severe anemia in patients with beta-thalassemia major.
PubMedID- 24428927	Rdw has been reported to have a high predictive value for ida [9,23] and can differentiate beta-thalassemia from other causes of anemia in populations [24,25].
PubMedID- 25006473	The present study shows the frequent occurrence of iron deficiency anemia in patients with beta thalassemia trait, which can potentially confound the diagnosis of the latter.
PubMedID- 24093062	On the basis of classical hematological parameters, subjects with ida are inappropriately discriminated from subjects with anemia due to thalassemia or chronic disease.
PubMedID- 23402775	thalassemia major presents with chronic hemolytic anemia that requires regular red blood cell transfusions within the first year of life.
PubMedID- 25574363	1,2,37,38 a report on alpha thalassemia with anemia in children’s revealed it should be considered differential diagnosis.39 on comparing the hematological parameters within the four groups, group 1( ida cases) had the most pronounced microcytosis even more than the cases with ida coexistent with α thalassemia mutation (group 3) which had more than that of α thalassemia cases (group 4).1 (mcv group1
PubMedID- 23827114	Objective: to investigate the clinical features and therapeutic method for severe aplastic anemia (saa) associated with beta-thalassemia, and to improve the recognition of the disease.
PubMedID- 25869286	The thalassemias, together with sickle cell anemia and its variants, are the world's most common form of inherited anemia, and in economically undeveloped countries, they still account for tens of thousands of premature deaths every year.
PubMedID- 25693142	In-vivo ablation of macrophages improves anemia associated with beta-thalassemia and reduces red blood cell counts in the mouse model of polycythemia vera.
PubMedID- 21209818	The preliminary investigations revealed that he had severe iron deficiency anemia coexisting with β thalassaemia trait and cholestatic liver derangement.
PubMedID- 25557470	In particular, the v736a tmprss6 polymorphism was associated to moderately lower hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin levels, and in thalassemia carriers with marked anemia and microcytosis.
PubMedID- 23056228	Diseases such as malaria, thalassemia minor, anemia, as well as many others, result in abnormal size distributions of red blood cells [17], [18].
PubMedID- 24399969	Found significantly increased plasma concentrations of anti-spectrin nabs in splenectomized patients with β-thalassemia major and in patients with sickle cell anemia (wiener et al., 1986).
PubMedID- 25969661	thalassemia major presents with anemia within the first 2 years of life requiring frequent blood transfusions for sustaining life.
PubMedID- 25883429	Severe hemolytic anemia in beta-thalassemia major and beta-thalassemias/hbe (beta-tm) patients requires giving blood transfusions.
PubMedID- 22475299	Autoimmune hemolytic anemia in patients with beta-thalassemia major.
PubMedID- 25000650	This patient, with a history of mild anemia due to beta-thalassemia minor and two known transfusion of packed red cells came to an emergency room complaining of severe abdominal cramps.
PubMedID- 21637571	The frequency of α-thalassemia in patients with microcytic anemia was significantly higher than in healthy volunteers, regardless of their ethnic origin (p = 0.001).
PubMedID- 24456650	Heterozygosity for a large duplication of the complete α-globin gene cluster, including the upstream regulatory element hs-40, was identified in a β-thalassemia carrier with severe hemolytic anemia (figure 4b).
PubMedID- 25574177	This study provides the basis for mechanisms of yssxg on thalassemia suffering with hemolysis and anemia of erythrocytes from patient.
PubMedID- 20871816	thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in malaysia.
PubMedID- 23284899	The transplanted homo-βthal mice displayed features of β-thalassemia major with severe anemia as evidenced by markedly decreased rbc count, hemoglobin and hematocrit levels and consequently, exhibit decreased blood viscosity (table 1).
PubMedID- 25863092	Conclusion: abnormal hemoglobin with alpha-thalassemia may lead to severe anemia, prenatal diagnosis of thalassemia has the vital significance for eugenic birth.

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