PedAM
Pediatric Disease Annotations & Medicines
| Disease | substance dependence |
| Phenotype | C0036341|schizophrenia |
| Sentences | 3 |
| PubMedID- 21569242 | Key exclusion criteria included primary dsm-iv axis i diagnosis other than schizophrenia, dsm-iv diagnosis of active substance dependence within 3 months before screening, history of treatment resistance (failure to respond to 2 adequate courses of different antipsychotic medications with a minimum of 4 weeks duration at the patient's maximum tolerated dose), history of neuroleptic malignant syndrome, a relevant history of any significant or unstable systemic disease, morbid obesity (body mass index ≥40 kg/m2), and circumstances that could increase the risk of the occurrence of torsade de pointes or sudden death. |
| PubMedID- 22869037 | Striatal dopamine release in schizophrenia comorbid with substance dependence. |
| PubMedID- 24724026 | Exclusion criteria were (a) neurologic disorders, (b) substance abuse in the past 1 month if it is the first episode, (c) substance abuse in the past 6 months if it is chronic schizophrenia, (d) lifetime history of substance dependence, (e) history of head injury with loss of consciousness greater than five minutes and/or posttraumatic amnesia, (f) cognitive impairment, and (g) medical illnesses associated with cognitive impairment. |
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