PedAM
Pediatric Disease Annotations & Medicines
| Disease | substance abuse |
| Phenotype | C0036341|schizophrenia |
| Sentences | 19 |
| PubMedID- 24839596 | “self-medication hypothesis” of substance abuse in schizophrenia suggests that schizophrenic patients use substances to self-medicate either depression [46], positive or negative symptoms [47], or extrapyramidal symptoms [9]. |
| PubMedID- 24324839 | Patients had no psychiatric disorder other than schizophrenia, no history of substance abuse or dependence, and no history of severe medical or neurological disorder. |
| PubMedID- 21629845 | The present study examined substance use outcomes and neurological and psychiatric symptoms in substance abusers with and without schizophrenia and in non-abusing schizophrenia patients undergoing a 12-week treatment with the atypical antipsychotic quetiapine. |
| PubMedID- 20669315 | Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia. |
| PubMedID- 21423445 | The high prevalence of substance abuse in patients with schizophrenia has sometimes been interpreted as self-medication for negative symptoms, anhedonia, depression or neuroleptic side effects, but no convincing evidence supports this idea (mueser et al., 1998; d'souza et al., 2006). |
| PubMedID- 22907121 | substance abuse in individuals with schizophrenia is very common; it has become the most prevalent comorbid psychiatric condition associated with schizophrenia and contributes to an unfavourable disease course [65]. |
| PubMedID- 22966436 | The high rate of noncompliance can be explained by poor insight into illness, cognitive deficits, and elevated substance abuse associated with schizophrenia and by side effects associated with antipsychotics such as anhedonia and extrapyramidal symptoms (eps) [3]. |
| PubMedID- 21389110 | We tested this hypothesis by examining age at onset of psychosis and cognition in schizophrenia patients with no substance abuse other than cannabis and tobacco and compared these with patients who had never used cannabis. |
| PubMedID- 20647266 | Despite a high prevalence of schizophrenia patients with comorbid substance abuse, little is known about possible impacts on the brain. |
| PubMedID- 23055987 | Further studies are necessary to understand the role of endocannabinoids in substance abusers with and without schizophrenia and to examine therapeutic implications. |
| PubMedID- 20406460 | Exclusion criteria eliminated individuals with cognitive impairment unrelated to hiv, such as: (1) neurological conditions (e.g., head injury, seizure disorder); (2) medical illness unrelated to hiv (e.g., chronic hepatic or renal failure, malignancy) or severe hiv-related disease (current opportunistic infection); (3) current fever; (4) severe psychiatric disorder (e.g., schizophrenia); (5) a history of substance abuse; and (6) inability to function independently. |
| PubMedID- 25815257 | There is consistent evidence that this trait is independently associated with alcohol and substance abuse in patients with schizophrenia and related disorders. |
| PubMedID- 21365002 | schizophrenia); (5) a history of substance abuse; (6) sensory impairment (e.g. |
| PubMedID- 22273390 | Along these lines, increasing evidence supports the possible beneficial properties of atypical neuroleptics in schizophrenia associated with substance abuse disorders [43]. |
| PubMedID- 23532750 | Previous studies have indicated that substance abuse in patients with schizophrenia can worsen eps. |
| PubMedID- 22170735 | The management of comorbid substance abuse in schizophrenia relies on the use of antipsychotic medications. |
| PubMedID- 22869037 | The epidemiologic catchment area study reported a 4.6-fold increase in the prevalence of any substance abuse in patients with schizophrenia compared to the general population.10 alcohol is most commonly used, with a lifetime prevalence of abuse or dependence of 33.7% compared to 27.5% for all other drugs. |
| PubMedID- 24403872 | substance abuse among individuals with schizophrenia is very high. |
| PubMedID- 24478729 | Scz + sa, schizophrenia patients with past substance abuse; con + sa, control participants with past substance abuse. |
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