PedAM
Pediatric Disease Annotations & Medicines
| Disease | splenomegaly |
| Phenotype | C0040034|thrombocytopenia |
| Sentences | 24 |
| PubMedID- 25488878 | These findings confirm previous observations of thrombocytopenia being associated with splenomegaly after donation. |
| PubMedID- 24641383 | Methods: cohort studies evaluating the impact of clinically significant pht, defined as oesophageal varices and/ or splenomegaly associated with thrombocytopenia, on the results of hepatectomy for hcc were identified using a predefined search strategy. |
| PubMedID- 19506870 | thrombocytopenia with rituximab treatment--splenomegaly as the risk factor. |
| PubMedID- 23074575 | We present a case of severe aortic valve stenosis with severe splenomegaly-induced thrombocytopenia in which aortic valve replacement was done with a number 23 homograft and splenectomy was performed after the end of cardiopulmonary bypass. |
| PubMedID- 23875049 | Such studies report a frequent thrombocytopenia associated with the splenomegaly and portal hypertension [17]. |
| PubMedID- 20439622 | Entry criteria required splenomegaly with thrombocytopenia and/or anemia. |
| PubMedID- 24019767 | Some reports have described hemorrhagic complications as one of the clinical features of gaucher disease, which is mostly associated with thrombocytopenia due to splenomegaly or esophageal varices due to liver cirrhosis. |
| PubMedID- 21445610 | Characteristic symptoms include splenomegaly with anemia and thrombocytopenia, hepatomegaly, and bone disease. |
| PubMedID- 22606518 | A 15-month-old female child was referred to our centre with the clinical sign of massive splenomegaly associated with thrombocytopenia and anemia. |
| PubMedID- 21566449 | After 3 courses of folfox and 6 courses of bevacizumab/folfox, he suffered from thrombocytopenia with splenomegaly, which led to discontinuation of the therapy. |
| PubMedID- 22354537 | thrombocytopenia was significantly associated with splenomegaly, renal disorders, neurologic manifestations, arterial thrombosis, leucopenia, low c3 level at sle diagnosis, sle relapses and infectious complications. |
| PubMedID- 23075171 | (a) this patient showed prolonged idiopathic thrombocytopenia presenting with increased splenomegaly and non-response to steroid therapy. |
| PubMedID- 25910248 | Hypersplenism was defined as splenomegaly with thrombocytopenia, leukopenia, anemia and bone marrow aspiration revealed by biopsy. |
| PubMedID- 26539006 | Baseline characteristics of the analyzed patients are shown in table 1. all enrolled patients had evidence of cirrhosis in the form of thrombocytopenia, cirrhotic configuration with or without splenomegaly, and/or varices. |
| PubMedID- 22959828 | This study confirms the allelic heterogeneity of td and suggests that the diagnosis of td must be considered in patients with an unexplained splenomegaly, associated with thrombocytopenia and hypocholesterolemia. |
| PubMedID- 24816856 | The main inclusion criteria were a diagnosis of gd1 confirmed by deficient acid β-glucosidase activity and gaucher genotype, age 18 to 65 years, the presence of splenomegaly with anemia, and/or thrombocytopenia [16–18]. |
| PubMedID- 23024865 | In this condition, splenomegaly is associated with thrombocytopenia, leucopenia, or anemia or a combination of any the three [95, 96]. |
| PubMedID- 24501607 | Patients suffering from the above-mentioned disorders are subjected to splenectomy if the following symptoms are present: thrombocytopenia, decrease of leukocyte number, splenomegaly with tenderness and pain as a result of recurring spleen infarctions and immune-mediated haemolytic anaemia requiring blood transfusion [1]. |
| PubMedID- 24761383 | Subsequently, she developed massive splenomegaly with thrombocytopenia and a 30-pound weight loss over six months. |
| PubMedID- 26267788 | In addition, it has been reported that splenomegaly leads to thrombocytopenia, associated with hypersplenism, in more than 60% of patients with hs schistosomiasis, especially in the advanced stages of the disease; however, relatively few patients present symptoms due to hypersplenism and need surgery [10]. |
| PubMedID- 23275773 | Between march 2010 and may 2012, 6 patients (4 males, 2 females) who were diagnosed with mcrc and experienced persistent thrombocytopenia associated with splenomegaly underwent laparoscopic or hand-assisted laparoscopic splenectomy to correct thrombocytopenia requiring cessation of chemotherapy (table 1). |
| PubMedID- 22787404 | He had a previous history of chronic alcoholism between the ages of 35 and 45 years (four bottles of beer per day) accompanied by secondary complications such as liver cirrhosis since age 25, steatosis hepatitis, portal hypertension, esophageal varices grade iii – which had been ligated at approximately 17 years of age and a second time 19 months prior to his current hospital admission – calcifying pancreatitis, chronic gastritis since age 14, splenomegaly with consecutive thrombocytopenia since age 8, pulmonary hypertension, and right ventricular hypertrophy due to hepatopulmonary syndrome since age 1. previous nonalcohol-related disorders included arterial hypertension, nephrolithiasis during the 1990s, cholecystectomy 8 years previous, af for the past 5 years, and a gastric polyp, which had been successfully resected 21 months prior to the current hospital admission. |
| PubMedID- 24137205 | Hypersplenism is diagnosed on the basis of clinical data that include splenomegaly with thrombocytopenia (cytopenia). |
| PubMedID- 22084665 | Thrombocytosis is present in ≈30% of pmf patients at diagnosis, with this number decreasing as the disease progresses and splenomegaly often leads to thrombocytopenia [90]. |
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