PedAM
Pediatric Disease Annotations & Medicines
| Disease | splenomegaly |
| Phenotype | C0024530|malaria |
| Sentences | 4 |
| PubMedID- 25948238 | Hepatomegaly or splenomegaly associated with malaria infection is mainly a result of repeated inflammatory responses characterized by hyperplasia of reticuloendothelial and lymphoid tissues [25], which can be exacerbated by chronic s. mansoni infection [23-25]. |
| PubMedID- 24440297 | These results suggest that splenomegaly in malaria is partly due to the accumulation of mrp8(+) and mrp14(+) macrophages. |
| PubMedID- 22540175 | This may explain why concomitant severe malarial anaemia with spleen enlargement and cerebral malaria is relatively unusual with cerebral manifestations being more common in acute, fulminant infections and anaemia being more likely in chronic infections [27,76,128,129]. |
| PubMedID- 21711191 | Lesions typical of avian malaria, including splenomegaly, hepatomegaly and severe pulmonary oedema were present in nine out of 48 penguins. |
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