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PedAM

Pediatric Disease Annotations & Medicines




Disease sleeping sickness
Phenotype C0041228|african sleeping sickness
Sentences 47
PubMedID- 24533305 Trypanosoma brucei is the causative agent of african sleeping sickness in humans and nagana in livestock, both of which have tremendous impact on the lives of people in sub-saharan africa (brun et al., 2010).
PubMedID- 25856578 Human african trypanosomiasis (hat), also known as african sleeping sickness, is a neglected tropical disease that affects mainly poor populations living in rural areas [1–3].
PubMedID- 23844111 The parasite trypanosoma brucei is the causative agent of african sleeping sickness in humans and one of several pathogens that cause the veterinary disease nagana.
PubMedID- 23451087 The protozoan parasites of the genera trypanosoma and leishmania cause neglected diseases such as chagas’ disease, african sleeping sickness or the various forms of leishmaniasis, which in toto still account for about 100 000 fatalities per annum[1] (http://www.who.int/mediacentre/factsheets/fs259/en/index.html).
PubMedID- 20879999 The african trypanosome trypanosoma brucei is a protozoan parasite, which causes african sleeping sickness in humans and ‘nagana’ in livestock, diseases that have a devastating impact on sub-saharan africa (hotez and kamath, 2009).
PubMedID- 25367138 Human african trypanosomiasis (african sleeping sickness), a disease caused by two subspecies of the protozoan parasite trypanosoma brucei (t. b. gambiense and t. b. rhodesiense), is estimated to kill ∼ 10 000 people in sub-saharan africa every year (aksoy, 2011).
PubMedID- 24763140 Tsetse flies transmit the causative agents of african sleeping sickness and nagana in sub-saharan africa.
PubMedID- 23090971 Trypanosoma brucei is a unicellular eukaryotic parasite that causes african sleeping sickness in humans and “nagana” in livestock in sub-saharan africa.
PubMedID- 24792668 This organism causes human african trypanosomiasis(african sleeping sickness) and nagana in cattle and is transmittedby the tsetse fly in much of sub-saharan africa.
PubMedID- 23622560 Trypanosoma cruzi (chagas disease) and t. brucei (african sleeping sickness) are collectively responsible for about 63,000 human deaths per year [1], while t. evansi (surra), t. vivax (nagana) and t. congolense (nagana) are all of great economic concern to livestock production in africa, asia and south america [2-4].
PubMedID- 25705365 It has been used medically for the treatment of african sleeping sickness (trypanosomiasis) since shortly after it was first synthesized in 1916. its antipurinergic actions were discovered in 1988, after a search for inhibitors of atp-mediated p2x and p2y signaling[17].
PubMedID- 24265767 African sleeping sickness (or human african trypanosomiasis) is a neglected disease affecting 60 million people in sub-saharan africa [1].
PubMedID- 24151595 The resistance to apol-1 of pathogens of african sleeping sickness was demonstrated by at least two different strategies with the neutralization by sra in the case of t. b. rhodesiense [148] or the limited sublethal uptake of apol-1 in the case of t. b. gambiense [149].
PubMedID- 20405000 African sleeping sickness is a disease found in sub-saharan africa that is caused by the single-celled parasite trypanosoma brucei.
PubMedID- 25585630 To demonstrate this assay, we detected synthetic nucleic acid sequences representative of trypanosoma mrna, the causative agent for african sleeping sickness, with relevance in human and animal health in sub-saharan africa.
PubMedID- 22242158 Diseases that cause high mortality, such as african sleeping sickness, cholera, streptococcal pneumonia, and smallpox were associated with lower levels of variation in susceptibility than were more benign infections, such as candidiasis, trichuriasis, mononucleosis and elephantiasis.
PubMedID- 23967363 African sleeping sickness is a fatal disease occurring in sub-saharan africa.
PubMedID- 22272367 African sleeping sickness is well known and recognised as a serious disease in the communities of kasai-oriental province.
PubMedID- 20808768 Neglected tropical diseases like african sleeping sickness cause significant death and suffering in the world's poorest countries.
PubMedID- 21829743 African sleeping sickness or human african trypanosomiasis (hat) is endemic to 36 countries in sub-saharan africa covering 9 million km2 with 60 million of the 400 million inhabitants at risk of the disease.
PubMedID- 23563972 Parasitic protists of the trypanosoma brucei family are causative agents of african sleeping sickness in humans and nagana of domestic animals.
PubMedID- 24498306 Trypanosoma brucei, the protozoan parasite that causes african sleeping sickness, owns five putative prmts in its genome [17], and four of these have been characterized: tbprmt1 and tbprmt6 with type i activity [18]–[19], tbprmt5 with type ii activity [20], and tbprmt7 with type iii activity [21].
PubMedID- 22952449 The causative agent of african sleeping sickness in humans and nagana in cattle, t. brucei is transmitted into the bloodstream of its host by a tsetse vector and can grow to densities as high as 109 cells per milliliter of blood.
PubMedID- 21603263 T. brucei and its subspecies are extracellular parasites transmitted by tsetse flies and responsible of human african trypanosomiasis (hat), also known as african sleeping sickness, and nagana in cattle.
PubMedID- 24550396 African trypanosomes are tsetse fly-transmitted protozoan parasites that cause human african sleeping sickness and nagana in livestock.
PubMedID- 25959766 Trypanosoma brucei is a parasitic protozoa, which causes african sleeping sickness in sub-africa region.
PubMedID- 22091393 Annual death numbers as a result of african sleeping sickness are difficult to determine, as limited monitoring in rural africa likely leads to underestimated infection rates.
PubMedID- 20205710 Trypanosoma brucei is the causative agent of african sleeping sickness in humans and similar disease in sylvatic and domestic animals [1] and is transmitted by tsetse flies (genus glossina).
PubMedID- 23635522 Trypanosoma brucei is the causative agent of african sleeping sickness, which kills more than 10 000 people annually in sub-saharan africa [47,48], whereas t. cruzi and leishmania species are responsible for chagas disease and leishmaniasis, respectively.
PubMedID- 22906508 T. brucei, the causative agent of african sleeping sickness, varies vsg antigen expression both by reorganisation in the vsg family dna sequence via duplication transposition at the telomerically located expression linked sites (els) [148] and transcriptional in situ switching between different els of which there are about 20 (suppl.
PubMedID- 23656927 Trypanosoma brucei is a parasitic protozoan and the causative agent of african sleeping sickness in humans and nagana in african livestock.
PubMedID- 24244771 Our results provide evidence that the causative agent of east african sleeping sickness, t. b. rhodesiense, can undergo genetic exchange in the field in malawi, in contrast to previous studies that have described t. b. rhodesiense as a genetically homogeneous variant of t. b. brucei.
PubMedID- 23516405 It has been used medically for the treatment of african sleeping sickness (trypanosomiasis) since shortly after it was first synthesized in 1916. its antipurinergic actions were discovered in 1988, after a search for inhibitors of atp-mediated p2x and p2y signaling [34].
PubMedID- 24596669 Trypanosoma brucei rhodesiense and t. b. gambiense respectively cause east- and west-african sleeping sickness in humans, also known as human african trypanosomiasis (hat).
PubMedID- 20594956 African sleeping sickness threatens over 50 million people in 36 sub-saharan african countries, and has an enormous effect also on the livestock and economic development of affected areas.
PubMedID- 23533609 Trypanosoma brucei, is an early divergent protozoan parasite that causes african sleeping sickness in human and nagana in livestock.
PubMedID- 23451133 Trypanosoma brucei is a protozoan parasite that causes african sleeping sickness in humans and a similar disease in livestock, in sub-saharan africa.
PubMedID- 22073170 Trypanosoma brucei species are the causative agents of human african trypanosomiasis (hat) or african sleeping sickness in humans and the wasting disease, nagana, in cattle.
PubMedID- 26302018 Galactose metabolism is essential tothe parasite’s ability to cause african sleeping sickness,a neglected tropical disease.53 the enzymeis active in dimeric and tetrameric forms; the target monomer is shownas gray surface.
PubMedID- 23515081 This parasite causes african sleeping sickness, a chronic disease in humans and nagana in cattle.
PubMedID- 20300417 East african sleeping sickness, caused by trypanosoma brucei rhodesiense, is prominent in uganda and poses a serious public health challenge in the region.
PubMedID- 20145711 The organisms that have been most extensively studied are trypanosoma brucei, the causative agent of african sleeping sickness, t. cruzi, responsible for chagas disease in south america, and leishmania spp., which causes leishmaniasis in asia, south america, and mediterranean countries [1].
PubMedID- 20558211 The tsetse transmitted african trypanosomes of the trypanosoma brucei group are the causative agents of human african trypanosomiasis, also known as african sleeping sickness, and nagana in cattle.
PubMedID- 20107599 Trypanosomes are the causative agent of major parasitic diseases such as african sleeping sickness, leishmaniasis and chagas' disease that affect millions of people mostly in developing countries.
PubMedID- 23615446 Trypanosoma brucei is a flagellated protist parasite that causes african sleeping sickness in humans and nagana in cattle.
PubMedID- 25886869 Human african trypanosomiasis also known as african sleeping sickness is caused by the protozoan parasites trypanosoma brucei rhodesiense and trypanosoma brucei gambiense in countries of sub-saharan africa [1].
PubMedID- 24278497 African sleeping sickness, or human african trypanosomiasis (hat), currently infects around 10,000 people per year and threatens the lives of a further 70 million people living in 36 countries of sub-saharan africa [1].

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