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PedAM

Pediatric Disease Annotations & Medicines




Disease sickle cell anemia
Phenotype C0024530|malaria
Sentences 4
PubMedID- 19901265 malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization.
PubMedID- 25567972 Heterozygote individuals have decreased vulnerability to malaria and limited symptoms of sickle cell disease; their relative fitness advantage explains the persistence of the sickle cell allele where malaria is prevalent (livingstone 1960; wiesenfeld 1967; piel et al.
PubMedID- 22131906 The question of whether the synesthesia gene(s) may have a “hidden agenda” like the sickle cell anemia gene has with malaria resistance, and whether that agenda may be “creativity and metaphor”, was first raised by ramachandran and hubbard [15].
PubMedID- 25250231 However, malarial anemia along with sickle cell disease accounted for 19.3% of all malaria related deaths [table 3].

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