PedAM
Pediatric Disease Annotations & Medicines
| Disease | severe combined immunodeficiency |
| Phenotype | C0178664|glomerulosclerosis |
| Sentences | 1 |
| PubMedID- 22318423 | Our previous studies have shown that reconstitution of tregs expressing high levels of foxp3 (forkhead box p3) in severe combined immunodeficient (scid) mice with an reduced glomerulosclerosis and tubular injury in comparison with control scid mice with an.21 our studies have also shown that macrophages modulated by il-10/tgf-β or il-13/4 are able to reduce renal injury in murine an.22, 23 in this study, we sought to determine whether or not adoptive transfer of splenic pdcs that were modified ex vivo to a regulatory phenotype and infused into an mice could protect mice against progressive renal injury. |
Page: 1