PedAM
Pediatric Disease Annotations & Medicines
| Disease | severe combined immunodeficiency |
| Phenotype | C0085110|severe combined immunodeficiency |
| Sentences | 101 |
| PubMedID- 24189293 | Previous studies demonstrated that cd34− severe combined immunodeficiency (scid)-repopulating cells (srcs) are a distinct class of primitive hscs in comparison to the well-characterized cd34+cd38− srcs. |
| PubMedID- 22844424 | Twenty four five-week old non-obese diabetic/severe combined immunodeficiency (nod/scid) male mice were purchased from the chinese association for laboratory animal science (calas; beijing, china) and housed under specific pathogen-free conditions, in a controlled temperature and humidity environment with 12 h light/dark cycles. |
| PubMedID- 23343349 | Ak 2 mutations cause reticular dysgenesis, the most severe combined immunodeficiency in humans [48]. |
| PubMedID- 26083776 | Female non-obese diabetic severe combined immunodeficiency (nod-scid) mice were purchased from clea and maintained in the animal facility of kobe university graduate school of medicine. |
| PubMedID- 24447304 | Eight week old female nonobese diabetic/severe combined immunodeficiency mice (nod/scid; harlan, in) were used as hosts for tumor xenografts. |
| PubMedID- 24465715 | Six-month-old male, severe combined immunodeficiency (scid) mice were housed in a barrier filter room and fed purina rodent chow ad lib. |
| PubMedID- 23841937 | Six- to eight-week-old severe combined immunodeficiency mice were implanted with glioblastoma u87 (n = 8) or adenocarcinoma mda-mb-231 (mda) (n = 11) in the shoulder. |
| PubMedID- 25944695 | Six- to eight-week-old male cb.17/severe combined immunodeficiency disease (scid) mice were inoculated subcutaneously with 5 × 106 oci-ly7 tumor cells in 0.1 ml pbs for tumor development. |
| PubMedID- 23542179 | Four-week male athymic nod cb17-prkdc/scid (severe combined immunodeficiency) mice were purchased from jackson laboratory and maintained in the animal facilities according to the protocol approved by the american association for accreditation of laboratory animal care. |
| PubMedID- 22829152 | The leukemic non-obese diabetic/severe combined immunodeficiency (nod/scid) mouse system with the in vivo combination treatment with imatinib and everolimus showed a decrease of tumor burden including cd34+ cells. |
| PubMedID- 21750681 | The recessive defect ‘severe combined immunodeficiency’ (scid), which is found in the arabian breed, comprises a fatal deficiency in t- and b-lymphocyte numbers and function. |
| PubMedID- 22363629 | We subsequently demonstrated that compared with balb/c mice, mice with severe combined immunodeficiency (scid) were acutely hypersensitive to 34-1-2 s effects indicating that recipient lymphocytes are important in significantly reducing severe lung damage induced by 34-1-2s [21]. |
| PubMedID- 21695116 | A variety of mutations are responsible for the scid (severe combined immunodeficiency syndrome) phenotype with a deficiency in different lymphoid cell populations [1]. |
| PubMedID- 22111002 | severe combined immunodeficiency (scid) is a rare disease in which the affected organism is unable to mount an immune response due to loss of b and t lymphocytes. |
| PubMedID- 24497838 | severe combined immunodeficiency (scid) beige mice were maintained in a pathogen–free environment under controlled conditions of light and humidity. |
| PubMedID- 23060872 | Immunodeficiencies, such as severe combined immunodeficiency (scid) or intermediate forms of combined immunodeficiency (cid), may present first with gastrointestinal symptoms, often fatal in early childhood if untreated (geha et al., 2007). |
| PubMedID- 23764770 | Female cb17 mice at 6–8 weeks of age with severe combined immunodeficiency (scid) were used for in vivo tumor modeling studies (charles river laboratories inc., holister, ca) and were housed in polycarbonate cages using a hepa-filtered, ventilated rack system (allentown inc., allentown, nj). |
| PubMedID- 20051957 | A total of 20 nod/scid (non-obese diabetic–severe combined immunodeficiency) female mice had 8 × 106 mda-mb-231 breast cancer cells in 100 μl phosphate-buffered saline (pbs; ph 7.4) plus 100 μl of matrigel (bd biosciences, san jose, ca, usa) injected into their left second mammary fat pads. |
| PubMedID- 24776983 | severe combined immunodeficiency (scid) mice, which are deficient in t and b cells, appear to be resistant to the enteropathic effects of seb. |
| PubMedID- 24318653 | Next, we utilized the severe combined immunodeficiency (nod-scid) mouse model and injected lymphoma cells with or without stromal cells and observed a more robust growth of tumor in mice receiving hk and lymphoma cells[7]. |
| PubMedID- 23646141 | Briefly, nod/scid (non-obese diabetic – severe combined immunodeficiency) female mice had mda-mb-231 breast cancer cells in 100 ml phosphate buffered saline (pbs; ph 7.4) plus 100 ml of matrigel (bd biosciences, san jose, ca, usa) injected into their left second mammary fat pads. |
| PubMedID- 23300452 | Moreover, consistent with the lack of enhanced susceptibility of patients with acquired immunodeficiency syndrome, severe combined immunodeficiency, x-linked agammaglobulinemia, and common variable immunodeficiency to invasive candidiasis, t and b lymphocytes are dispensable for host defense in the mouse model [26]. |
| PubMedID- 26425655 | Jak3 and/or stat5b mutations that cause severe combined immunodeficiency (scid) syndrome in humans) are prone to severe infections. |
| PubMedID- 23202463 | Used the severe combined immunodeficiency disorder (scid) mice transgenic for urokinase plasminogen activator (upa) under control of the albumin (alb) promoter that transplanted with human hepatocyte model (scid/alb-upa chimeric mice model) for hcv infection to test whether hcv can activates er stress in vivo [53]. |
| PubMedID- 25346775 | Adoptive immunization of severe combined immunodeficiency mice with t cells from 2d2 live-attenuated bpm mutant-immunized mice resulted in increased survival compared to naïve t cell recipients. |
| PubMedID- 22941246 | Adult nonobese diabetic/severe combined immunodeficiency interleukin 2 receptor gamma chain knock out (nsg) mice (jackson laboratories, bar harbor, me), were used for in vivo experiments according to protocols approved by the institutional animal care and use committee of university of california los angeles. |
| PubMedID- 20824134 | Nonobese diabetic/severe combined immunodeficiency (nod/scid) mice were bred and maintained in the johns hopkins animal core facility. |
| PubMedID- 21701688 | Briefly, female, severe combined immunodeficiency (scid) mice (17–20 g, 4–6 weeks old) were bred in house and maintained throughout in specific pathogen-free (spf) isolators. |
| PubMedID- 21544519 | severe combined immunodeficiency (scid) is part of the differential diagnosis of cd40l deficiency (van der burg m, gennery a, the expanding spectrum of severe combined immunodeficiency, ejp in press), but in contrast to most cases of scid, analysis of lymphocyte subpopulation in pad patients will show normal t cell counts. |
| PubMedID- 24389287 | Nod/scid (non-obese diabetic/severe combined immunodeficiency) mice were injected with 1.5x106 sk-n-as cells in pbs and matrigel basement membrane matrix (100μm) (bd biosciences, franklin lakes, nj usa) subcutaneously in the left flank. |
| PubMedID- 24740260 | Cells with deletion of any of these nhej components show severe combined immunodeficiency (scid) due to defects in assembling variable (diverse) joining (v(d)j) segments of antigens, genetic instability and hypersensitivity to dsb inducing agents [5]–[9]. |
| PubMedID- 20979627 | Nhej defects lead to severe combined immunodeficiency (scid) and lymphoid cancer predisposition in both mice and humans. |
| PubMedID- 24466340 | Lastly, mutations of dna-pkcs cause severe combined immunodeficiency in mice [17], [18], [19], [20]. |
| PubMedID- 26022250 | The derivations of nude and severe combined immunodeficiency (scid) mice, which are widely used for xenotransplantation, were milestones in the development of immunodeficient mice. |
| PubMedID- 23898329 | Due to the severe combined immunodeficiency background, these mice are deficient in functional mature t and b cells. |
| PubMedID- 23264026 | severe combined immunodeficiency (scid), characterized by extremely low or absent t cell production, defective t cell function and absent antibody responses, can be caused by defects in any of several genes and if untreated leads to early death due to infections [1, 2]. |
| PubMedID- 21379384 | severe combined immunodeficiency (scid) mice, first successfully established in 1983 by bosma et al. |
| PubMedID- 21170549 | An effective diagnostic strategy should be able to quickly identify pids with rapidly fatal complications like severe combined immunodeficiency (scid) and to limit diagnostic delay in children with pids with a more protracted course like common variable immunodeficiency disorders (cvids), who may develop bronchiectasis with pulmonary disability [15] and decreased life span if treatment is delayed. |
| PubMedID- 24728301 | The 6- to 8-week old male nod-scid mice (non-obese diabetes severe combined immunodeficiency mice) were used to evaluate the in vivo meta-static behavior of tumor cells. |
| PubMedID- 23831714 | We also performed fluorescence microscopy ivfc on severe combined immunodeficiency (scid) mice in parallel (as has been described in detail previously)5 to compare and validate the msc clearance kinetics measured with the dffc prototype. |
| PubMedID- 25972190 | Severe acquired immunodeficiencies (e.g., uncontrolled hiv or severe combined immunodeficiency) or genetic defects in the il-23/th17 pathway can increase patients' susceptibility to a number of syndromes that are all associated with chronic or recurrent mucosal or skin infections with candida albicans (table 1; puel et al., 2010b; hanna and etzioni, 2011; huppler et al., 2012). |
| PubMedID- 25283340 | severe combined immunodeficiency (scid) mice were bred and maintained in the animal facility of the department of dermatology (university of debrecen) in accordance with the animal-welfare ordinance. |
| PubMedID- 21589826 | Patients with a complete absence of the thymus (“complete” digeorge syndrome) exhibit severe t-cell immunodeficiency with a severe combined immunodeficiency phenotype requiring immune reconstitution by bone marrow transplantation or thymic transplantation.5–7 however, “complete” digeorge syndrome accounts for <1% of patients.8,9 the majority of patients with 22q11.2 ds and immune defects exhibit mild to moderate deficits in t-cell numbers (so-called “partial” digeorge syndrome). |
| PubMedID- 24592361 | [91011] these vectors are used for the treatment of a number of diseases such as β-thalassemia, hemophilia, severe combined immunodeficiency (scid), cystic fibrosis, and muscular and neurodegenerative diseases in animal models. |
| PubMedID- 20668627 | Ada deficiency is the major metabolic cause of severe combined immunodeficiency disease.31,32 ada is important for the development of the immune system in humans. |
| PubMedID- 25550434 | Female severe combined immunodeficiency (scid) mice (charles river laboratory) in the +dox group were switched to 400 ppm doxycycline diet (harlan) 3 days prior to implant, while animals in the −dox group were maintained on standard mouse diet. |
| PubMedID- 22469436 | A 12-year-old girl with severe combined immunodeficiency was admitted to the freiburg university medical center, germany, in november 2009 for treatment of progressive respiratory problems and cytomegalovirus (cmv) disease. |
| PubMedID- 21573181 | Immunodeficient non obese diabetous/shi-severe combined immunodeficiency/interleukin-2rγnull (nog) mice were injected with pm7 and ags mixed at a ratio of 8∶1 (2 250 000 and 375 000 cells, respectively) resuspended in 200 µl of 7 mg/ml matrigel (bd biosciences) in ice cold pbs. |
| PubMedID- 24670249 | Female nod-scid (non-obese diabetic-severe combined immunodeficiency; tzu chi university, hualien, taiwan mice were purchased from jackson lab, bar harbor, me, usa) and housed under specific pathogen-free conditions in the animal center of the institute of cellular and organismic biology of sinica. |
| PubMedID- 22355452 | severe combined immunodeficiency (scid) mice lack both humoral and cellular responses due to deficiencies in b and t cell development. |