PedAM
Pediatric Disease Annotations & Medicines
| Disease | severe combined immunodeficiency |
| Phenotype | C0085110|severe combined immunodefic |
| Sentences | 174 |
| PubMedID- 20498638 | Non-obese diabetic/severe combined immunodeficient/interleukin-2 receptor γ-chain-deficient mice were used in all experiments. |
| PubMedID- 20594324 | 5-6 weeks old female severe combined immunodeficiency mice (scid) mice were obtained from harlan laboratory (harlan laboratories, inc, indianapolis, in) and maintained under pathogen free conditions in a temperature and humidity controlled animal care facility with a 12 hours light dark cycle. |
| PubMedID- 25738875 | Six-week-old non-obese diabetic–severe combined immunodeficiency (nod/scid) mice were supplied by the national laboratory animal center, taipei, taiwan, and housed in specific pathogen-free animal rooms. |
| PubMedID- 21170549 | An effective diagnostic strategy should be able to quickly identify pids with rapidly fatal complications like severe combined immunodeficiency (scid) and to limit diagnostic delay in children with pids with a more protracted course like common variable immunodeficiency disorders (cvids), who may develop bronchiectasis with pulmonary disability [15] and decreased life span if treatment is delayed. |
| PubMedID- 23300452 | Moreover, consistent with the lack of enhanced susceptibility of patients with acquired immunodeficiency syndrome, severe combined immunodeficiency, x-linked agammaglobulinemia, and common variable immunodeficiency to invasive candidiasis, t and b lymphocytes are dispensable for host defense in the mouse model [26]. |
| PubMedID- 20051957 | A total of 20 nod/scid (non-obese diabetic–severe combined immunodeficiency) female mice had 8 × 106 mda-mb-231 breast cancer cells in 100 μl phosphate-buffered saline (pbs; ph 7.4) plus 100 μl of matrigel (bd biosciences, san jose, ca, usa) injected into their left second mammary fat pads. |
| PubMedID- 24740260 | Cells with deletion of any of these nhej components show severe combined immunodeficiency (scid) due to defects in assembling variable (diverse) joining (v(d)j) segments of antigens, genetic instability and hypersensitivity to dsb inducing agents [5]–[9]. |
| PubMedID- 22111066 | Three severe combined immunodeficiency (scid) mice (males, 6 weeks old) were injected with a suspension of 1×109 cells/ml in the back; however, no tumor formation was observed after 6 weeks. |
| PubMedID- 22253631 | Among them, nude mice that are athymic, and thus t-cell deficient, [37] and severe combined immunodeficient mice (scid) carrying an autosomal recessive mutation that severely affect lymphopoiesis, which makes mice that are homozygous for this mutation deficient in b and t lymphocytes [38], are the most frequently used for ovarian tissue xenografts. |
| PubMedID- 22363629 | We subsequently demonstrated that compared with balb/c mice, mice with severe combined immunodeficiency (scid) were acutely hypersensitive to 34-1-2 s effects indicating that recipient lymphocytes are important in significantly reducing severe lung damage induced by 34-1-2s [21]. |
| PubMedID- 24069355 | Thus, for the first time we present t-b-nk+ severe combined immunodeficiency (scid) phenotype after spontaneously occurring modification of artemis gene in mice. |
| PubMedID- 21973190 | The nonobese diabetic/severe combined immunodeficient (nod/scid, nod-cb17-prkdcscid/j) mice, purchased from jackson laboratory (bar harbor, me, usa), were raised in a pathogen-free environment in filtered cages. |
| PubMedID- 23842453 | 8-10-week-old female severe combined immunodeficient (scid) and nude (nu/nu) mice (vital river, beijing, china) were used in this study. |
| PubMedID- 24116047 | Female non-obese diabetic/severe combined immunodeficiency (nod/scid) mice (5 week-old) were purchased (clea japan, inc., osaka, japan), and housed in laminar-flow cabinets under specific pathogen-free conditions. |
| PubMedID- 25972190 | Severe acquired immunodeficiencies (e.g., uncontrolled hiv or severe combined immunodeficiency) or genetic defects in the il-23/th17 pathway can increase patients' susceptibility to a number of syndromes that are all associated with chronic or recurrent mucosal or skin infections with candida albicans (table 1; puel et al., 2010b; hanna and etzioni, 2011; huppler et al., 2012). |
| PubMedID- 24078865 | They successfully corrected severe combined immunodeficiency (scid)-x1 in 11 children using a mouse leukemia virus-based vector (mlv) as the gene transfer vehicle. |
| PubMedID- 23190608 | Male cb-17 severe combined immunodeficient (scid) mice (6- to 8-weeks old; harlan laboratories, inc., indianapolis, in, usa) were housed and monitored in our animal research facility. |
| PubMedID- 23300447 | severe combined immunodeficiency (scid) mice engrafted with human pbmc depleted of nk cells are more susceptible to fatal lymphoproliferation of infused ebv-infected b cells than non-depleted controls, indicating a role for nk cells in preventing outgrowth of infected b cells [35]. |
| PubMedID- PMC4407161 | Os characterized by symptoms of severe combined immunodeficiency (scid), in association with the cardinal triad of hepatosplenomegaly, lymphadenopathy and erythroderma. |
| PubMedID- 23902739 | Briefly, five-week-old male c.b.-17 severe combined immunodeficient (scid) mice (taconic farms, germantown, ny) were used in the study. |
| PubMedID- 26045973 | Four- to 6-week-old severe combined immunodeficient (scid) out bred mice (taconic, germantown, ny) was maintained in approved pathogen-free institutional housing. |
| PubMedID- 23110132 | Nod-scid (non-obese diabetic/severe combined immunodeficient) mice (harlan ltd., uk) were injected intraperitoneally with 3×106 huh7, or mia-paca2 cells suspended in 150 µl pbs. |
| PubMedID- 21609494 | Eight to sixteen week old female c57bl/6 mice and c57bl/6 severe combined immunodeficient (scid) mice (charles river laboratories, wilmington, ma) were used in protocols approved by the institutional review board of the university of pennsylvania. |
| PubMedID- 24198970 | Hyper-ige and wiskott-aldrich syndromes, cd40l deficiency, severe combined immunodeficiency, x-linked agammaglobulinemia, transient hypogammaglobulinemia of infancy, and chronic granulomatous disease were diagnosed in these children. |
| PubMedID- 20706692 | Likewise, reconstitution of severe combined immunodeficient mice or recombinase activating gene 1 deficient mice with naïve cd4+cd45rbhi positive t cells results in significant intestinal inflammation and barrier disruption again due to dysregulation of lymphocyte responses [32]. |
| PubMedID- 23318460 | Furthermore 24 severe combined immunodeficiency mice were divided into three groups and in each group, eight mice were injected with mock/293, b7-h4 wt/293 or b7-h4 h250q mt/293 cells, respectively. |
| PubMedID- 23646141 | Briefly, nod/scid (non-obese diabetic – severe combined immunodeficiency) female mice had mda-mb-231 breast cancer cells in 100 ml phosphate buffered saline (pbs; ph 7.4) plus 100 ml of matrigel (bd biosciences, san jose, ca, usa) injected into their left second mammary fat pads. |
| PubMedID- 23226942 | Such studies are complemented by a pediatric patient with t and b cell severe combined immunodeficiency (scid) that mounted a potent nk cell response to human cytomegalovirus (cmv) [19], indicating that nk cells may provide host protection against viral pathogens in the absence of adaptive immunity. |
| PubMedID- 24402744 | Six-week-old female severe combined immunodeficiency (scid)/cb17 mice were purchased from charles river breeding laboratories (calco, italy), housed under specific pathogen-free conditions in the bl2 containment laboratory in our animal facility, and allowed to acclimate to local conditions for 1 week. |
| PubMedID- 24138807 | The authors suggest that severe combined immunodeficient (scid) mice would be a good model for chronic q fever as immunodeficiency is a risk factor for chronic q fever in humans. |
| PubMedID- 22355452 | severe combined immunodeficiency (scid) mice lack both humoral and cellular responses due to deficiencies in b and t cell development. |
| PubMedID- 23807770 | Cb-17 severe combined immunodeficient (scid) mice (charles river laboratories, wilmington, ma, usa) were monitored in the animal research facility at dfci, and subjected to studies approved by the animal ethics committee. |
| PubMedID- 23060872 | Immunodeficiencies, such as severe combined immunodeficiency (scid) or intermediate forms of combined immunodeficiency (cid), may present first with gastrointestinal symptoms, often fatal in early childhood if untreated (geha et al., 2007). |
| PubMedID- 25077897 | Female cb-17/severe combined immunodeficient (scid) mice (charles river laboratories, wilmington, ma) at 7–12 weeks of age were maintained in a pathogen-free environment, and all in vivo procedures were performed in strict accordance with the nih guide for the care and use of laboratory animals and approved by the synta pharmaceuticals corp. institutional animal care and use committee. |
| PubMedID- 23776540 | Male nonobese diabetic (nod)/severe combined immunodeficiency (scid) mice, 6–8 weeks of age (slac laboratory animal company, shanghai, china), were fed in laminar flow cabinets under specific pathogen-free conditions. |
| PubMedID- 23936793 | A mouse model of severe combined immunodeficiency disease (scid) [27] was developed in which conjoint implants of human fetal thymus and liver were placed under the kidney capsule with subsequent infection of hcmv [28]. |
| PubMedID- 25944695 | Six- to eight-week-old male cb.17/severe combined immunodeficiency disease (scid) mice were inoculated subcutaneously with 5 × 106 oci-ly7 tumor cells in 0.1 ml pbs for tumor development. |
| PubMedID- 25550434 | Female severe combined immunodeficiency (scid) mice (charles river laboratory) in the +dox group were switched to 400 ppm doxycycline diet (harlan) 3 days prior to implant, while animals in the −dox group were maintained on standard mouse diet. |
| PubMedID- 19833883 | Mice deficient for nhej factors other than cernunnos/xlf (4) develop severe combined immunodeficiency due to their failure to join dna breaks generated during early lymphoid development in a dna rearrangement process termed v(d)j recombination (5). |
| PubMedID- 23831714 | We also performed fluorescence microscopy ivfc on severe combined immunodeficiency (scid) mice in parallel (as has been described in detail previously)5 to compare and validate the msc clearance kinetics measured with the dffc prototype. |
| PubMedID- 22829152 | The leukemic non-obese diabetic/severe combined immunodeficiency (nod/scid) mouse system with the in vivo combination treatment with imatinib and everolimus showed a decrease of tumor burden including cd34+ cells. |
| PubMedID- 24189293 | Previous studies demonstrated that cd34− severe combined immunodeficiency (scid)-repopulating cells (srcs) are a distinct class of primitive hscs in comparison to the well-characterized cd34+cd38− srcs. |
| PubMedID- 23841937 | Six- to eight-week-old severe combined immunodeficiency mice were implanted with glioblastoma u87 (n = 8) or adenocarcinoma mda-mb-231 (mda) (n = 11) in the shoulder. |
| PubMedID- 24466340 | Lastly, mutations of dna-pkcs cause severe combined immunodeficiency in mice [17], [18], [19], [20]. |
| PubMedID- 21695116 | A variety of mutations are responsible for the scid (severe combined immunodeficiency syndrome) phenotype with a deficiency in different lymphoid cell populations [1]. |
| PubMedID- 26339191 | These studies require nude (athymic) or severe combined immunodeficient (scid) rodents that are t- and b-cell deficient to allow for engraftment and growth of the human tumor xenograft.28 in addition to compromised adaptive immune systems in these animals, there are changes in innate immunity, including increased natural killer (nk) cell activity and tumoricidal macrophages.28 non-syngeneic, immunocompromised host models, therefore, provide an in vivo system in which human cancer cells can be passaged within a bone microenvironment and produce tumors with greater histopathological similarity to those encountered in human beings.29 this opportunity allows for both the study of genetic changes necessary for the survival of tumor cells within the bone microenvironment and changes in the bone microenvironment induced by engraftment of human cancer cells.29 non-syngeneic models with signaling incompatibilities may preclude ligands of the host species from interacting with tumor receptors of the donor species and vice versa.29 the downfall of using such rodents is the inability of the immune system to play its natural role in contributing to the proliferative, inflammatory, and painful processes. |
| PubMedID- 24670249 | Female nod-scid (non-obese diabetic-severe combined immunodeficiency; tzu chi university, hualien, taiwan mice were purchased from jackson lab, bar harbor, me, usa) and housed under specific pathogen-free conditions in the animal center of the institute of cellular and organismic biology of sinica. |
| PubMedID- 26425655 | Jak3 and/or stat5b mutations that cause severe combined immunodeficiency (scid) syndrome in humans) are prone to severe infections. |
| PubMedID- 22895085 | Eight-week-old scid mice (mice with severe combined immunodeficiency, background c.b-17lcr-prkdcscid/lcrcrl) were used as recipients of transferred cells.38,39 conventional balb/c anncrl were used as the donors of transferred cells. |
| PubMedID- 24389287 | Nod/scid (non-obese diabetic/severe combined immunodeficiency) mice were injected with 1.5x106 sk-n-as cells in pbs and matrigel basement membrane matrix (100μm) (bd biosciences, franklin lakes, nj usa) subcutaneously in the left flank. |