PedAM

Pediatric Disease Annotations & Medicines

Disease	septicemia
Phenotype	C0027947\|neutropenia
Sentences	39
PubMedID- 25970182	Atg side effect (long-standing neutropenia leading to sepsis) was considered as cause of death in one patient.
PubMedID- 25918250	Adverse events were graded according to the national cancer institute common terminology criteria for adverse events (ctcae), version 3.0. dlt was defined as any grade 4 toxicity (except for alopecia, or vomiting in the absence of adequate prophylaxis), fever or sepsis concurrent with grade 3-4 neutropenia, symptomatic thrombocytopenia (hemorrhage), any grade 3 cardiotoxicity and any toxicity requiring a treatment delay longer than 15 days.
PubMedID- 22633505	In premature infants, early-onset neutropenia is correlated with sepsis, maternal hypertension, intrauterine growth restriction, severe asphyxia, and periventricular haemorrhage, and might be associated with an increase in the incidence of early-onset sepsis, nosocomial infection, and candida colonisation.
PubMedID- 22426640	Dlt was defined as any grade 4 toxicities, grade 3 neutropenia or the occurrence of neutropenic sepsis, grade 3 thrombocytopenia or any grade 3 toxicities that did not return to grade1/2 within 3 weeks, except for alopecia.
PubMedID- 23192498	Independent factors associated with initial cr-gnb were profound neutropenia, the presence of severe sepsis and active haematological disease.
PubMedID- 23989947	Dose-limiting toxicities (dlts) were evaluated during cycle 1 and were defined as follows: anc <0.5 × 109 per l for >5 days; grade 3 neutropenia with fever (⩾38.5 °c), sepsis or other severe infection; platelet count <25.0 × 109 per l; any other grade 3/4 nonhaematological adverse event (ae) suspected to be treatment related (except for nausea/vomiting without an optimal antiemetic regimen, hypersensitivity reactions and nonclinically relevant biochemical abnormalities); and any delays in the administration of a subsequent plitidepsin dose exceeding 2 weeks, or omissions of the infusions scheduled on days 8 and 15 because of treatment-related aes.
PubMedID- 23205339	One had gastric perforation resulting in death [56], one had cardiac complications [54], and one had sepsis with neutropenia 7.25 months later [54].
PubMedID- 22052139	Considering the 50% mortality rate of neonatal septicemia associated with neutropenia and increasing resistance to antibiotics, simultaneous antibiotic therapy strategies are becoming more important.
PubMedID- 26065059 Patients	The guideline development group (gdg) recognises the importance of distinguishing uncomplicated neutropenic fever from neutropenia with severe sepsis and shock, and indeed septic shock can occur without fever.
PubMedID- 21808399	These include studies on its use in determining bacterial sepsis in children with febrile neutropenia, its use as a marker of renal parenchymal infection and its use as a marker of the severity of acute pancreatitis.
PubMedID- 21687537	The patient had multiple episodes of febrile neutropenia with concomitant sepsis producing delays and dose reduction of chemotherapy.
PubMedID- 21489333	Moreover, as g-csf is often applied in induction-chemotherapy-induced neutropenia, the role of neutropenia-related sepsis in the included trials remains unclear.
PubMedID- 24027727	[26] estimates suggest that when sepsis is associated with severe neutropenia, mortality exceeds 50%.
PubMedID- 25861347	However, neutropenia combined with sepsis could lead to life-threatening.
PubMedID- 24777705	Observed a significant higher rate of bacteraemia, potentially resulting in sepsis, in patients with neutropenia <0.5 g/l.
PubMedID- 22828545	The study concluded that before routine use of rhg-csf in neonatal sepsis with neutropenia further large scale, multi-centre, randomized, placebo controlled trial are needed to validate the beneficial effect.
PubMedID- 24983551	[serum lactate as a biomarker of severe sepsis in children with cancer, neutropenia and fever].
PubMedID- 23746966	Dose-limiting toxicities included severe neutropenia with infection and sepsis, mucositis/stomatitis, and diarrhea.
PubMedID- 23915833	Among the several factors that contribute to a higher risk of sepsis complications in patients with cancer, chemotherapy-associated neutropenia is probably the single-most important one [29].
PubMedID- 23935969	The third one, a 57-year old patient in group a, died from sepsis associated with febrile neutropenia and diarrhea after the completion of the third cycle.
PubMedID- 22592515	Conclusions: of three markers potentially useful for diagnosing bacterial sepsis in children with fever and neutropenia, pct had comparable diagnostic accuracy to crp.
PubMedID- 24495297	neutropenia was complicated by sepsis with elevated procalcitonin (pct: 13.6 ng/ml) and c-reactive protein (crp: 259 mg/l) one week after the 4th bolus of cyclophosphamide.
PubMedID- 22467971	Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a labrador retriever dog.
PubMedID- 22367386	Background and aim: early diagnosis of sepsis in children with febrile neutropenia and cancer still remains a challenge for modern medicine because of lack of specific laboratory markers and clinical signs especially at the beginning of the infection.
PubMedID- 23090499	Two patients died after consolidation from sepsis in neutropenia on days 74 and 77, respectively, after start of induction therapy (table 4).
PubMedID- 21074176	Preeclampsia, neutropenia, and risk of fungal sepsis in preterm very low birth weight infants.
PubMedID- 21894754	A male patient received non-chemotherapeutic drugs which induced deep neutropenia complicated with sepsis, bilateral pneumonia, acute respiratory insufficiency.
PubMedID- 20207442	Unanticipated grade 3 hepatotoxitity, hyponatremia, mental status changes, grade 3 and 4 thrombocytopenia, and grade 4 neutropenia with sepsis were observed.
PubMedID- 23239932	Two cases had documented septicemia with g4 neutropenia while the third one fell into a coma with unknown etiology and died.
PubMedID- 23056733	sepsis and pneumonia owing to neutropenia and respiratory distress may occur[5].
PubMedID- 21906359	Antibiotic therapy must be initiated immediately in febrile patients with neutropenia, especially when criteria of severe sepsis are met [1,2].
PubMedID- 23259255	This observational study was conducted between april 2006 and march 2007 in japan to evaluate the efficacy and safety of drpm 0.5 g three times a day for sepsis with neutropenia in patients with hematologic diseases.
PubMedID- 23799041	The exclusion criteria included presence of infection with human immunodeficiency virus and/or aids, neutropenia not attributable to sepsis, treatment with immunosuppressive therapies (use of systemic glucocorticoids equivalent to 0.5 mg or more of prednisone/kg/day within a month prior to admission to the icu; treatment with other major immunosuppressive drugs; or radiation therapy), pregnancy, or blood diseases (such as hematological tumors).
PubMedID- 23738899	However, the disease relapsed only two months later and he succumbed to sepsis in neutropenia upon salvage immunotherapy with lenalidomide in preparation for allogeneic stem cell transplantation.
PubMedID- 23248429	She developed febrile neutropenia with sepsis during the third week of induction.
PubMedID- 24535696	Maltophilia pneumonia or sepsis because of chemotherapy-induced neutropenia or immunodeficiency.
PubMedID- 25031945	The one patient in the 3.6-mg/kg cohort experienced febrile neutropenia complicated with presumed sepsis, which ultimately resulted in unexpected mortality (grade 5 toxicity) 14 days after receiving the initial dose (younes et al., 2010).
PubMedID- 21572797	On day 21, she developed acute renal failure and severe sepsis with neutropenia and was managed by the infectious diseases physician.
PubMedID- 25301539	Febrile neutropenia-induced sepsis resulted in the death of 1 patient with significant medical comorbidities; 2 other patients died of comorbidities unrelated to their cancer or treatment.

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