PedAM
Pediatric Disease Annotations & Medicines
| Disease | septicemia |
| Phenotype | C0002395|alzheimer\'s disease |
| Sentences | 1 |
| PubMedID- 24481454 | Rodents fed zn2+-deficient diets suffer exacerbated pathology in models of colitis38 and polymicrobial sepsis.39 humans with alzheimer's disease (ad) are also zn2+ deficient.40, 41 in this respect, ad is particularly interesting as we know that aggregated aβ, a pathological feature of ad, induces nlrp3 inflammasome activation via a mechanism dependent upon destabilisation of lysosomes and cathepsin b.28 the memory deficits that occur in the app/ps1 mouse model of ad also appear to be entirely dependent upon the nlrp3 inflammasome.42 in a negative feedback loop, zn2+ inhibits nf-κb-dependent inflammation via the zn2+ transporter zip8, itself regulated by nf-κb, and does this via an inhibition of iκb kinase.43 under conditions of zn2+ deficiency liu et al.43 report excessive inflammation in a model of sepsis as a result of losing this negative feedback. |
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