PedAM
Pediatric Disease Annotations & Medicines
| Disease | schizophrenia |
| Phenotype | C0679466|cognitive deficits |
| Sentences | 145 |
| PubMedID- 21798517 | Although animal models have captured negative symptoms and cognitive deficits associated with schizophrenia, none have addressed these defining, positive symptoms. |
| PubMedID- 20053170 | cognitive deficits in patients with schizophrenia are the biggest obstacle to achieving an independent and productive lifestyle, with these deficits being refractory to current drug treatments. |
| PubMedID- 25287873 | This study aims to assess specificity and degree of cognitive deficits in inpatients with acute schizophrenia and unipolar major depression. |
| PubMedID- 23591167 | Swm may be an important neurobiological substrate of cognitive performance and a novel cortical treatment target for cognitive deficits in schizophrenia patients. |
| PubMedID- 24124576 | According to this hypothesis, the behavioral and cognitive deficits seen in patients with a schizophrenia spectrum disorder are caused by disturbed functional and/or anatomical communication between distant brain regions, which normally constitute a network. |
| PubMedID- 24043839 | Postmortem studies have suggested that cognitive deficits in schizophrenia are correlated with modifications in the number and size of inhibitory synapses. |
| PubMedID- 23623456 | We tested the hypothesis that right anterior insula modulation of central executive and default mode networks is disrupted in schizophrenia and associated with cognitive deficits. |
| PubMedID- 22957138 | The initial two-way ancova controlling for age and gender showed that the main effect of diagnosis was significant for all the seven cognitive factors (all p-values < 0.001), confirming the association of schizophrenia with pervasive neurocognitive deficits. |
| PubMedID- 20967473 | Siuciak reviewed in 2008 the role of phosphodiesterases in psychosis and she concludes that both isoenzymes bear great potential for the treatment of positive symptoms, negative symptoms and/or cognitive deficits associated with schizophrenia (siuciak 2008). |
| PubMedID- 23995185 | Background: cognitive deficits in schizophrenia are regarded by many psychiatrist as an important symptom, which requires appropriate treatment and rehabilitation. |
| PubMedID- 24703529 | cognitive deficits in schizophrenia underlie more functional disability than any other symptom of the illness and existing treatments are largely inadequate. |
| PubMedID- 22570726 | Although evidence suggests that smoking may ameliorate a number of cognitive deficits associated with schizophrenia, the association between smoking and cognitive deficits has been under-examined among chinese patients. |
| PubMedID- 20451258 | Growing interest in cognitive deficits associated with schizophrenia has led to the need for a clinician-friendly cognitive instrument. |
| PubMedID- 23034345 | Conclusions: our results support the use of a six-factor model and suggest that the cognitive factor could be a valid measure of cognitive deficits in schizophrenia, although the use of a standard neuropsychological battery is advisable. |
| PubMedID- 24288608 | cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. |
| PubMedID- 26121151 | Studies are detailed that find greater levels of these impairments, defined as metacognitive deficits, in persons with schizophrenia in both early and later phases of illness as compared with other clinical and community groups. |
| PubMedID- 23914162 | Based on the core cognitive deficits found in patients with schizophrenia seven cognitive domains were identified including working memory and attention/vigilance (green et al., 2004). |
| PubMedID- 26169626 | Background: although cognitive deficits in patients with schizophrenia are rooted early in development, the impact of psychosis on the course of cognitive functioning remains unclear. |
| PubMedID- 23769891 | Furthermore, cognitive deficits in schizophrenia appear well before the onset of psychosis and have been reported to be present during early childhood and even during the first year of life. |
| PubMedID- 20488434 | Translational animal models of cognitive deficits with relevance to schizophrenia are critical for gaining insights into the mechanisms underlying these impairments and developing more effective treatments. |
| PubMedID- 21555247 | This article focuses on cognitive deficits associated with schizophrenia to illustrate: a) how non-invasive eeg biomarkers of cognitive function constitute such a 'higher level correlate' of underlying pathologies. |
| PubMedID- 22283751 | Finally, progress in developing allosteric muscarinic receptor agonists and modulators will be discussed and it will be argued the muscarinic m1 receptor allosteric agonists and/or modulators may have the potential to improve the cognitive deficits associated with schizophrenia whilst muscarinic m4 receptor modulates may have antipsychotic effects. |
| PubMedID- 24847231 | Among the core cognitive deficits observed in patients with schizophrenia are disruptions in behavioral flexibility (pantelis et al., 1999; brown et al., 2009; leeson et al., 2009) which are also seen after mia in the male, but not female, offspring of rats (zuckerman and weiner, 2005; zhang et al., 2012; savanthrapadian et al., 2013). |
| PubMedID- 25871975 | A genome-wide association study of cognitive deficits in patients with schizophrenia in japan found association with a missense genetic variant (rs7157599, asn8ser) in the delta(4)-desaturase, sphingolipid 2 (degs2) gene. |
| PubMedID- 23637704 | In addition, this snp was also shown to have a potential association with the p300 endophenotype (decoster et al., 2012) and a significant association with cognitive deficits in patients with schizophrenia using a variety of tasks (green et al., 2012; cummings et al., 2013). |
| PubMedID- 22565235 | cognitive deficits in schizophrenia have been hypothesized to be caused by altered synaptic transmission in circuits of the prefrontal cortex. |
| PubMedID- 23251669 | Additionally, previous studies have demonstrated that structural and functional abnormalities in broca's area were associated with clinical symptoms and cognitive deficits in patients with schizophrenia, suggesting that deficits in this area may reflect the core pathology of schizophrenia. |
| PubMedID- 26164820 | Metacognitive deficits predict future levels of negative symptoms in schizophrenia controlling for neurocognition, affect recognition, and self-expectation of goal attainment. |
| PubMedID- 26159728 | None of the studies reviewed assessed the range of neurocognitive deficits associated with schizophrenia as outlined in the matrics consensus battery. |
| PubMedID- 20688137 | A case is made for reasons that the nrg-erbb signaling pathway constitutes a "biologically plausible" system for understanding the pathogenic mechanisms that may underlie the complex array of positive, negative and cognitive deficits associated with schizophrenia during development. |
| PubMedID- 23017655 | Social cognitive deficits in schizophrenia and their relationship to clinical and functional status. |
| PubMedID- 25679135 | To test the veracity of the ketamine model further, research is attempting to replicate a range of cognitive deficits associated with schizophrenia in healthy controls under the influence of ketamine. |
| PubMedID- 19751542 | Background: it has become widely accepted that cognitive deficits in schizophrenia are related to functional outcome. |
| PubMedID- 25379239 | Considerable research efforts have been devoted to characterizing the cognitive deficits associated with schizophrenia over the past few decades, though disagreement remains concerning the precise nature of the cognitive impairments. |
| PubMedID- 22669170 | Among the cognitive deficits observed in patients with schizophrenia, recent work has indicated abnormalities in multisensory integration, a process that is important for the formation of comprehensive environmental percepts and for the appropriate guidance of behavior. |
| PubMedID- 24179465 | This compound is still under development for the treatment of ad and cognitive deficits associated with schizophrenia, but preliminary results in pharmacokinetic, safety, and tolerability profiles of abt-107 suggest that it is a good candidate for further development [146]. |
| PubMedID- 24726270 | Social cognitive deficits in schizophrenia are well documented and related to functional outcome. |
| PubMedID- 24885177 | Conclusions: these findings suggest that neurocognitive deficits predispose people with schizophrenia to worse psychiatric symptoms through the impairment of social cognition. |
| PubMedID- 22456094 | Given the effects of cognitive deficits associated with schizophrenia on functional disability, there remains an ongoing need to identify effective means of directly ameliorating them. |
| PubMedID- 22355184 | Because gamma-band synchrony is thought to be crucial for cognition, cognitive deficits in schizophrenia may reflect pv neuron dysfunction in cortical neural circuits. |
| PubMedID- 25804359 | These results suggest that tandospirone is a promising candidate for the treatment of cognitive deficits associated with schizophrenia and that adjunctive treatment with tandospirone and blonanserin is more appropriate for cognitive deficits than combination therapy with tandospirone and risperidone or haloperidol. |
| PubMedID- 24953512 | Then, we discuss the complex relationship between cognitive deficits in patients with schizophrenia, problems in task performance, and disease-related effects on brain activation measured by fmri. |
| PubMedID- 25324619 | Background: cognitive remediation therapy (crt) is one of the promising new non-drug approaches to reducing cognitive deficits of patients with schizophrenia that has not yet been fully evaluated in china. |
| PubMedID- 21833224 | Furthermore, heinrichs (2007) concludes that cognitive deficits in patients with schizophrenia appear for the most part unresponsive to antipsychotic medication and this regardless of the type of drug. |
| PubMedID- 21249164 | Taken together, these findings suggest that ssr180711 has the potential to improve cognitive deficits associated with schizophrenia and ad. |
| PubMedID- 21956441 | This study examined the effects of a sub-chronic ketamine treatment to model cognitive deficits associated with schizophrenia, and to evaluate the effectiveness of nicotine, antipsychotic clozapine, and the novel mglu2/3 agonist, ly404039, in restoring ost performance. |
| PubMedID- 24047425 | Objective: the course of neurocognitive deficits in schizophrenia has not yet been established. |
| PubMedID- 23618463 | While environmental influences are widely suggested to play a contributory role in development of this illness, genetics and familial predisposition play a very significant role: a meta-analytic review on cognitive performance between relatives of schizophrenic patients and healthy control subjects demonstrated that the same cognitive deficits found in patients with schizophrenia are also found in non-affected relatives [198]. |
| PubMedID- 24365456 | While an association has been reported between metabolic disturbance and cognitive deficits, including speed of processing deficits, in schizophrenia (meyer et al.2005; lindenmayer et al.2012), further investigation of possible bidirectionality is warranted in psychotic illness where cognitive impairment antedates the onset of metabolic disorders. |
| PubMedID- 21167848 | Furthermore, these results may have implications for developing effective therapeutics for the cognitive deficits associated with schizophrenia because a large subset of patients with schizophrenia exhibit cognitive deficits that may be related to nmdar dysfunction and smoke at much higher rates than the healthy population, which may be an attempt to ameliorate cognitive deficits. |