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PedAM

Pediatric Disease Annotations & Medicines




Disease sarcoma
Phenotype C0025202|melanoma
Sentences 5
PubMedID- 24168510 Clear cell sarcoma shares features with melanoma, but frequently shows ewsr1 rearrangements.
PubMedID- 22493355 Materials and methods: to evaluate the existence of different molecular aberration patterns in melanoma associated with v-raf murine sarcoma viral oncogene homolog b1 (braf) or 9p21 locus alterations, eleven patient-derived melanoma cell lines were characterized.
PubMedID- 24237784 Under code c.69 where eye cancers are reported, the four main groups are retinoblastoma, malignant melanoma, carcinomas (11.4% of all eye cancers), sarcoma and other unspecified tumours.
PubMedID- 23825798 The most common mutations in sporadic melanoma are those of v-raf murine sarcoma viral oncogene homolog b1 (braf) and neuroblastoma ras viral oncogene homolog (nras), both of which result in constitutive activation of the mapk pathway and subsequent activation of pro-proliferative genes such as cyclin-d1 (ccnd1) (onken et al., 2008).
PubMedID- 22674423 Results: the following patients had indications for ue ili: melanoma, 36 of 47 patients (77%); sarcoma, 5 of 47 patients (11%); merkel cell sarcoma, 3 of 47 patients (6%), and squamous cell carcinoma, 3 of 47 patients (6%).

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