PedAM
Pediatric Disease Annotations & Medicines
| Disease | salmonellosis |
| Phenotype | C0002895|sickle-cell disease |
| Sentences | 1 |
| PubMedID- 21903251 | First, malaria causes haemolytic anaemia, a mechanism believed to be important in the increased susceptibility to invasive salmonellosis in children with bartonellosis or sickle-cell disease.4,21 experimentally induced haemolysis also increases susceptibility to salmonellosis in mice.23 second, accumulation of haemozoin pigment in monocytes impairs diverse macrophage functions, inhibiting expression of intercellular adhesion molecule-1, integrin-cd11c, and mhc class ii antigens, delaying differentiation into functional antigen-presenting cells, and stimulating proinflammatory cytokines and chemokines.24 each of these functions has a role in antibacterial immunity. |
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