PedAM
Pediatric Disease Annotations & Medicines
| Disease | rheumatic fever |
| Phenotype | C0035439|rheumatic heart disease |
| Sentences | 4 |
| PubMedID- 23273191 | Streptococcus pyogenes infection in human, causes initially pharyngitis due to inhalation of aerosols emitted by infected persons, develops rheumatic fever which leads to the rheumatic heart disease (damage of heart valves). |
| PubMedID- 22276281 | Discussion: recurrent episodes of acute rheumatic fever may lead to rheumatic heart disease. |
| PubMedID- 20356787 | Background: acute rheumatic fever, leading to rheumatic heart disease (rhd), is rare in australia except amongst aboriginal and torres strait islander people. |
| PubMedID- 22685225 | rheumatic fever complicated by rheumatic heart disease (rhd) remains a major contributor to morbidity and premature death among the socioeconomically underprivileged working age population of developing countries.1 rhd results from an autoimmune response due to molecular mimicry between the m-protein on the group a β-haemolytic streptococci cell membrane and cardiac myosin eventually leading to valvular damage.2 high prevalence rates of acute rheumatic fever (arf) and rhd have been reported from different geographic regions around the world such as southeast asia, the western pacific and africa that share demographic characteristics determined by poverty and limited access to healthcare resources.3 the burden of rhd is likely to escalate in these countries due to increasing urbanisation and overcrowding. |
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