PedAM
Pediatric Disease Annotations & Medicines
| Disease | proteinuria |
| Phenotype | C0011854|type 1 diabetes |
| Sentences | 5 |
| PubMedID- 23908777 | Recently, to study the genesis of proteinuria in individuals with type 1 diabetes, the urine proteome in 12 healthy non-diabetic individuals was compared with the urine proteome in 12 subjects with type 1 diabetes and normal urinary albumin excretion rates as well as 12 subjects with type 1 diabetes and microalbuminuria.70 megalin and cubilin, two multiligand receptors expressed in kidney proximal tubule cells that enable re-uptake of filtered albumin and megalin/cubilin ligands, were significantly increased in those with type 1 diabetes and microalbuminuria compared with the other two groups. |
| PubMedID- 25664053 | Results: calcitriol supplementation alleviated inflammation and proteinuria in patients with type 1 diabetes. |
| PubMedID- 21949629 | In addition to the landmark trial by lewis et al demonstrating that the acei captopril reduced both the combined primary end point (time to doubling of serum creatinine, death or the need for dialysis) and proteinuria in patients with type 1 diabetes, other clinical trials involving fewer numbers of patients have also demonstrated a beneficial effect of aceis and arbs on proteinuria in patients with diabetes and in hypertensive and normotensive patients without diabetes with immunoglobulin nephropathy.49 although the dose-dependency of this effect of aceis and arbs on protein has not been extensively examined, dose-titration of agents from either class seems warranted in patients with proteinuria, to monitor for possible adverse effects as the dosage is increased. |
| PubMedID- 22187315 | We investigated the possible association of urinary heparanase activity with the development of proteinuria in patients with type 1 diabetes (t1d), type 2 diabetes (t2d), or membranous glomerulopathy (mgp) as non-diabetic disease controls. |
| PubMedID- 20332124 | Inflammatory and endothelial dysfunction markers and proteinuria in persons with type 1 diabetes mellitus. |
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