PedAM
Pediatric Disease Annotations & Medicines
| Disease | proteinuria |
| Phenotype | C0011847|diabetes |
| Sentences | 48 |
| PubMedID- 25893098 | Monitoring for proteinuria in patients with type 2 diabetes mellitus. |
| PubMedID- 22145829 | Background: proteinuria in patients with diabetes mellitus (dm) is sometimes caused by glomerular diseases other than diabetic nephropathy. |
| PubMedID- 19889469 | Diabetic nephropathy remission and regression team trial in japan (dnett-japan) is an open, randomized controlled trial to evaluate the efficacy of renal protection of multifactorial intensive therapy in type 2 diabetes patients with overt proteinuria (urinary albumin-to-creatinine ratio > or =300 mg/g creatinine). |
| PubMedID- 25401694 | In addition to mgfr, an older age, diabetes, and lower levels of body mass index, proteinuria, and protein intake assessed by urinary urea were associated with lower mean urinary creatinine excretion at baseline. |
| PubMedID- 20490905 | Small, short term studies have examined the effects of high dose arb treatment on proteinuria in patients with diabetes and proteinuria. |
| PubMedID- 25876173 | Obstructive sleep apnea rather than diabetes or obesity associated with proteinuria in late mid-aged male workers: a decision tree analysis. |
| PubMedID- 26239680 | Halimi, in a recent review, concluded that progressive deterioration of renal function due to diabetes without developing significant proteinuria is common, is seen fairly frequently, and can affect 50% of patients with renal insufficiency [53]. |
| PubMedID- 20617081 | It has also been reported that hyperhomocysteinemia precedes the development of overt proteinuria in patients with type 2 diabetes [13]. |
| PubMedID- 25018963 | Microalbuminuria is much more common than frank proteinuria or albuminuria in patients with diabetes, but it is also associated with an increased risk of kidney and cardiovascular events. |
| PubMedID- 22400116 | Thus, the aim of this ancillary study was to investigate the effect of treatment with the lmwh dalteparin on proteinuria in patients with diabetes and severe vascular complications. |
| PubMedID- 20425064 | Angiotensin-converting enzyme (ace) inhibitors and angiotensin receptor blockers (arbs) are indispensable therapeutic agents for treating hypertension and proteinuria in patients with diabetes mellitus. |
| PubMedID- 25812668 | Type ii diabetes patients with proteinuria and the recovery of their metabolic parameters. |
| PubMedID- 22187315 | We investigated the possible association of urinary heparanase activity with the development of proteinuria in patients with type 1 diabetes (t1d), type 2 diabetes (t2d), or membranous glomerulopathy (mgp) as non-diabetic disease controls. |
| PubMedID- 26089878 | In addition, omega-3 fa could slow the progression of proteinuria in patients with type 2 diabetes, but the study in question included patients who were not controlling their bp [4]. |
| PubMedID- 20168990 | In the present study, we extended a previous large-scale association study for diabetic nephropathy, and provide evidence that a snp within the acetyl-coenzyme a (coa) carboxylase beta gene (acacb; mim: 601557) contributes to an increased prevalence of proteinuria in patients with type 2 diabetes across different ethnic populations. |
| PubMedID- 26517838 | These results show that diabetes with clinical proteinuria is accompanied by decreased urinary and serum level of ttp and increased levels of il-6 and il-18. |
| PubMedID- 24628963 | It has been reported to increase the risk of cardiovascular diseases and mortality in such patients [14] and to promote proteinuria in patients with type 2 diabetes [15]. |
| PubMedID- 22474041 | Finally, we examined the association of a +1 sd increase of pulse pressure (+13 mmhg), rather than pulse pressure as a dichotomous variable, with proteinuria in patients with diabetes by a multivariable logistic regression analysis. |
| PubMedID- 23514843 | To further investigate the interaction of proteinuria with hypertension and diabetes, logistic regression was separately performed in urban and rural residents (table 4). |
| PubMedID- 20419132 | We previously described that pkcα deficient mice show a better outcome after streptozotocin (stz) induced diabetes with less proteinuria and preserved nephrin expression [5], [6]. |
| PubMedID- 24843742 | The purpose of the present study was to emphasize hbv‐associated nephropathy in the differential diagnosis of clinical proteinuria in patients with diabetes mellitus. |
| PubMedID- 21949629 | In addition to the landmark trial by lewis et al demonstrating that the acei captopril reduced both the combined primary end point (time to doubling of serum creatinine, death or the need for dialysis) and proteinuria in patients with type 1 diabetes, other clinical trials involving fewer numbers of patients have also demonstrated a beneficial effect of aceis and arbs on proteinuria in patients with diabetes and in hypertensive and normotensive patients without diabetes with immunoglobulin nephropathy.49 although the dose-dependency of this effect of aceis and arbs on protein has not been extensively examined, dose-titration of agents from either class seems warranted in patients with proteinuria, to monitor for possible adverse effects as the dosage is increased. |
| PubMedID- 22218118 | Angiotensin receptor blocker and n-acetyl cysteine for reduction of proteinuria in patients with type 2 diabetes mellitus. |
| PubMedID- 26109389 | Selective vitamin d receptor activator paricalcitol effectively reduce proteinuria in patients with type 2 diabetes through inhibition of the renin-angiotensin-aldosterone system (raas) [12]. |
| PubMedID- 23209764 | The selective vitamin d receptor (vdr) activator, paricalcitol, effectively reduces proteinuria in patients with type 2 diabetes mellitus (t2dm) who have been treated with raas inhibitors [6]. |
| PubMedID- 26083525 | A previous study indicated that the combination of acei and furosemide was a risk factor for cin because it significantly decreased gfr and increased proteinuria in patients with diabetes and hypertension [49]. |
| PubMedID- 21782146 | The prevalence of microalbuminuria and proteinuria in cats with diabetes mellitus. |
| PubMedID- 22250064 | In adults with type 1 diabetes, the incidence of gross proteinuria was associated with wider retinal venules, but not arterioles (9). |
| PubMedID- 23714217 | Methods: eighty-four type 2 diabetes patients with overt proteinuria and biopsy-confirmed diabetic nephropathy were enrolled. |
| PubMedID- 22318512 | Kim et al.26 found that the expression of nephrin, which is a functional molecule located between slit diaphragms or two adjacent foot processes of podocytes, plays a critical role in proteinuria associated with diabetes,23,24,27 and that nephrin expression was significantly reduced in large glomeruli compared with small glomeruli in streptozotocin-induced diabetic rats. |
| PubMedID- 23781466 | This is used for treatment of hypertension and diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type-2 diabetes and hypertension. |
| PubMedID- 23414596 | In addition there were four health states of low gfr chronic kidney disease (ckd: ckd and diabetes mellitus with and without proteinuria and ckd and non-diabetes mellitus with and without proteinuria) and one state of esrd. |
| PubMedID- 24391440 | A pilot study104 indicated that oral sdx at 200 mg daily was more often successful, although not significantly, than placebo in inducing at least 50% reduction of proteinuria in patients with type 2 diabetes treated with maximal allowed doses of ace inhibitors or arbs. |
| PubMedID- 24841129 | Low-grade proteinuria was also associated with concomitant diabetes and exposure to nucleoside reverse transcriptase inhibitor [anytime during hiv infection, not tenofovir (tdf)-specific], whereas tubular proteinuria was linked to current and any exposure to nucleoside reverse transcriptase inhibitor (tdf-specific). |
| PubMedID- 23169362 | The effect of pentoxifylline on reduction of proteinuria among patients with type 2 diabetes under blockade of angiotensin system: a double blind and randomized clinical trial. |
| PubMedID- 21694939 | The incidence of cin is about 11.3% using the definition of a 25% increase in serum creatinine or an absolute increase in serum creatinine of 0.5 mg/dl.56 radiocontrast agents cause aki by inducing renal vasoconstriction followed by hypoxic tubular injury.57,58 predisposing factors include age (>55 years), prior renal insufficiency, diabetes mellitus with neurovascular complications, proteinuria, volume depletion, acute liver failure, and recent nephrotoxic drug exposure.59 the onset of renal failure usually is abrupt within 24 hours after exposure to contrast media and is characterized by oliguria, but it may be nonoliguric.60 recovery of renal function generally occurs. |
| PubMedID- 26169541 | It was reported to slow the progression of renal injury in a rat model of type 2 diabetes with preexisting proteinuria and renal disease (kojima et al. |
| PubMedID- 23908777 | Recently, to study the genesis of proteinuria in individuals with type 1 diabetes, the urine proteome in 12 healthy non-diabetic individuals was compared with the urine proteome in 12 subjects with type 1 diabetes and normal urinary albumin excretion rates as well as 12 subjects with type 1 diabetes and microalbuminuria.70 megalin and cubilin, two multiligand receptors expressed in kidney proximal tubule cells that enable re-uptake of filtered albumin and megalin/cubilin ligands, were significantly increased in those with type 1 diabetes and microalbuminuria compared with the other two groups. |
| PubMedID- 23431093 | In the same wesdr study, these associations were also confirmed in 557 patients with type 1 diabetes and 16-year incidence of gross proteinuria and renal insufficiency (31). |
| PubMedID- 26300986 | Some studies reported that pentoxifylline reduced proteinuria in subjects with diabetes, while other studies have failed to show a clear-cut anti-proteinuric effect of pentoxifylline [9–15]. |
| PubMedID- 23270101 | The addition of spironolactone to the combination of an ace inhibitor, and arb, and a direct renin inhibitor brought about dramatic and sustained reversal of 4-plus proteinuria in a patient with diabetes mellitus and hypertension. |
| PubMedID- 24145991 | (grade: weak recommendation, low-quality evidence) recommendation 2: acp recommends against testing for proteinuria in adults with or without diabetes who are currently taking an angiotensin-converting enzyme inhibitor or an angiotensin ii-receptor blocker. |
| PubMedID- 24732208 | diabetes increases prevalence of renal insufficiency and proteinuria among the elderly [34, 35]. |
| PubMedID- 24357461 | Of note, single nucleotide polymorphisms in acetyl-coa carboxylase β gene, which plays an important role in the regulation of fatty acid metabolism, exhibit a potent association with proteinuria in patients with type 2 diabetes [6, 7]. |
| PubMedID- 20705966 | Because the consequences of calcification may differ by vascular beds, we sought to test the hypothesis that patients who have diabetes with proteinuria and have significant renal artery calcification (rac) have a higher risk for progression to esrd. |
| PubMedID- 26132137 | Impaired fmd was also associated with proteinuria in patients with diabetes or hypertension [8,9]. |
| PubMedID- 21053070 | proteinuria was significantly associated with age and diabetes, hematuria was associated with age, female sex and smoking status, and leukocyturia was associated with age and female sex. |
| PubMedID- 23544132 | Nevertheless, kubo et al have reported wt1 mrna in whole urine from only 40% (8 in 20) diabetes mellitus patients with proteinuria [19]. |
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