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PedAM

Pediatric Disease Annotations & Medicines




Disease progressive multifocal leukoencephalopathy
Phenotype C0010346|crohn\'s disease
Sentences 3
PubMedID- 23232602 Objective: natalizumab, a highly effective treatment for multiple sclerosis (ms) and crohn's disease, is associated with progressive multifocal leukoencephalopathy (pml).
PubMedID- 20594122 There have been reports of progressive multifocal leukoencephalopathy after treatment with natalizumab in crohn's disease and multiple sclerosis.
PubMedID- 20565845 Due to detailed brain autopsies, natalizumab, a novel antibody directed to the adhesion molecule a4 integrin, was identified as a risk factor for development of progressive multifocal leukoencephalopathy in patients with crohn's disease or multiple sclerosis treated with this drug [28].

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