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PedAM

Pediatric Disease Annotations & Medicines




Disease primary myelofibrosis
Phenotype C0001815|myelofibrosis
Sentences 15
PubMedID- 20359349 Clonal dysregulation linked to myeloproliferative neoplasms (mpn) arising from acquired mutations in the haematopoietic progenitor cells lead to a wide range of clonal haematological malignant diseases including polycythemia vera (pv), essential thrombocythemia (et), myeloid metaplasia with myelofibrosis (mmm), chronic myelomonocytic leukemia (cmml), chronic myelogenous leukemia (cml), hypereosinophilic syndrome (hes), and systemic mast cell disease (smcd)[1].
PubMedID- 23756559 An increase in circulating cd34+ cells has been described in myelofibrosis with myeloid metaplasia in adults (30) and in raeb in adults (31) and in children, associated with a low apoptotic rate (25).
PubMedID- 23259545 myelofibrosis with myeloid metaplasia (mmm) is a rare malignant hematological disease of the hematopoietic stem cells with a median age at diagnosis of 60 years.
PubMedID- 23259436 Altogether, the stepwise progress of myelofibrosis in cimf was associated with expression of a defined subset of target genes as shown in sequential trephine biopsies of cimf patients.
PubMedID- 22548075 Most of the reported pulmonary extramedullary hematopoiesis is seen in myelofibrosis with myeloid metaplasia, a subgroup of chronic myeloproliferative disorders.
PubMedID- 23208557 This mutation has been identified in most polycythemia vera (pv) patients, approximately half of essential thrombocythemia (et) and chronic idiopathic myelofibrosis with extramedullary hematopoiesis (cimf) patients, and in a substantial population of other chronic myeloproliferative disease (cmpd) patients [40].
PubMedID- 21870730 [myeloid metaplasia with myelofibrosis associated with acute coronary syndrome.
PubMedID- 24744667 Also suggested that pv patients homozygous for jak2v617f are more prone to transformation into myelofibrosis with myeloid metaplasia.
PubMedID- 19785025 Chronic idiopathic myelofibrosis (cim) with myeloid metaplasia is a myeloproliferative disorder characterized by leukoerythroblastosis, tear drop erythrocytes, extra-medullary hematopoesis (emh), and varying degree of myelofibrosis.
PubMedID- 23457485 Exclusion criteria were prior chronic renal dysfunction, previously treated malignancy (>4 weeks after the first chemotherapy dose), relapsing or refractory hematological malignancy, bone marrow or stem cell transplantation, low-grade or chronic malignancy (chronic myelogenous leukemia, chronic lymphocytic leukemia, low-grade nhl, multiple myeloma, myelodysplastic syndrome, myelofibrosis with myeloid metaplasia, or aplastic anemia), and absence of potentially lifespan-extending treatment options.
PubMedID- 22282696 Increase in fibrosis is due to liberation of cytokines such as tgf-β and pdgf from dysplastic megakaryocytes.15 the differential diagnosis includes myelofibrosis with myeloid metaplasia, chronic myelocytic leukemia and acute megakaryocytic leukemia.
PubMedID- 22704352 Report reduction of myelofibrosis in mice with jak2+ primary myelofibrosis (pmf) when pmf cells are treated sequentially with decitabine and saha (vorinostat) or trichostatin a in vitro prior to transplantation (wang et al.
PubMedID- 21224796 The role of splenectomy in myelofibrosis with myeloid metaplasia.
PubMedID- 20615740 Objective: lenalidomide (ldm) is an immunomodulatory and anti-angiogenic drug which has been shown to be effective in several haematological disorders (multiple myeloma [mm], myeloid metaplasia with myelofibrosis [mf] and myelodysplastic syndrome [mds]).
PubMedID- 24880208 Essential thrombocytosis (et) falls under the umbrella of myeloproliferative disorders, which also includes chronic myelogenous leukemia, polycythemia vera, and myelofibrosis with myeloid metaplasia.

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