PedAM
Pediatric Disease Annotations & Medicines
| Disease | primary biliary cirrhosis |
| Phenotype | C0008370|cholestasis |
| Sentences | 2 |
| PubMedID- 25688837 | Our findings suggest that bile canalicular lumen expansion might explain the presence of cholestasis in patients with primary biliary cirrhosis and primary sclerosing cholangitis. |
| PubMedID- 23311897 | This is in line with previous data since cholestasis in cases of primary biliary cirrhosis or progressive familial intrahepatic cholestasis is associated with reduced oatp1b1 and oatp1b3 expression [12] and the concerted down-regulation of both bile salt uptake transporters is considered as a protective mechanism against hepatocellular injury caused by cytotoxic bile acids. |
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