PedAM
Pediatric Disease Annotations & Medicines
| Disease | pneumococcal infections |
| Phenotype | C0032285|pneumonia |
| Sentences | 11 |
| PubMedID- 20591180 | Furthermore, case fatality rates of pneumonia with invasive pneumococcal disease increase sharply from 20% (for person 65 years or older) to 40% (for persons 85 years or older) [8]. |
| PubMedID- 21621575 | Pcv-13, with higher coverage of local serotypes, would prevent more cases of pneumonia, invasive pneumococcal disease, sequelae and deaths with a higher number of lyg and dalys averted, but pcv-10, due its higher impact in the prevention of aom, would save more costs to the healthcare system. |
| PubMedID- 23785543 | There is also a clear link between influenza and pneumonia, with pneumococcal infection being a major cause of mortality during influenza epidemics [20]. |
| PubMedID- 21666794 | It is well documented that balb/c and cba mice show variation in susceptibility to infection and pathology associated with a number of pathogens including leishmania major, streptococcus pneumonia, the cause of acute pneumococcal disease [31], [32], and candida albicans [33]. |
| PubMedID- 21191300 | We contrast the potential differences in prevention of invasive pneumococcal disease compared with nonbacteremic pneumonia and acute otitis media. |
| PubMedID- 21695128 | A prospective, observational study of the cytokine profile and genetic determinants of invasive pneumococcal disease (children presenting with pneumonia or meningitis) was undertaken at queen elizabeth central hospital (qech), blantyre, between 1st april 2004 and 30th october 2006. the details of the study participants and recruitment procedures have been previously reported [25], [26], [27]. |
| PubMedID- 23228352 | Invasive pneumococcal disease (ipd) associated with streptococcus pneumonia is a major public health problem worldwide for all age groups, including in lebanon. |
| PubMedID- 26015944 | Pneumococcal infection is the leading cause of community-acquired pneumonia and can lead to invasive pneumococcal disease that includes bacteremia, septicemia, pneumonia, and meningitis.1,2 it is estimated that community-acquired pneumonia alone accounts for 1 million physician visits and 60,000 hospitalizations annually in canada, costing about $100 million.3 the incidence of invasive pneumococcal disease in adults remains high, whereas the highest incidence is in the elderly and in children less than 5 years of age, particularly in aboriginal children living in northern canada.1,4 worldwide, s. pneumoniae continues to be the most significant bacterial pathogen in children, causing ~25% of all preventable deaths in children less than 5 years of age and 1.6 million infant deaths per year in developing countries.2,5,6 in addition, s. pneumoniae superinfection is the most common complication of influenza, which together form the leading cause of death from infectious diseases in canada.3,7 alarmingly, s. pneumoniae outbreaks have occurred across canada and elsewhere in north america in the last 10 years.8 treatment is complicated by the continuous emergence of antibiotic-resistant s. pneumoniae serotypes, the narrow serotype-specific protection provided by conjugate polysaccharide vaccines, and the ever-shifting bacterial serotypes away from the serotypes covered by the vaccine in invasive infections of vaccinated children.2,9,10 thus, there has been a pressing need for enhanced understanding of host defense mechanisms and development of novel therapeutic agents against pneumococcal diseases, particularly those caused by antibiotic resistant strains. |
| PubMedID- 20815900 | Our results show that a routine pcv program is expected to prevent, over the first 5 years of life of a birth cohort, approximately 1040-1650 cases of primary endpoint pneumonia, 470-740 hospitalizations due to severe pneumococcal diseases, and 30-50 pneumococcal deaths, as well as avert 740-1180 dalys, depending on the valences of pcvs (pcv7 to pcv13) used. |
| PubMedID- 20728764 | The main limitation of this study was uncertainty regarding how great a proportion of pneumonia could be attributed to pneumococcal disease. |
| PubMedID- 19900170 | Amelioration of pneumonia with streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model. |
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