PedAM
Pediatric Disease Annotations & Medicines
| Disease | pertussis |
| Phenotype | C0043167|whooping cough |
| Sentences | 10 |
| PubMedID- 26375454 | whooping cough due to bordetella pertussis is increasing in incidence, in part due to accumulation of mutations which increase bacterial fitness in highly vaccinated populations. |
| PubMedID- 23027528 | Parapertussis in whooping cough cases has been increasing since the introduction of acellular pertussis vaccines containing purified antigens that are common to both strains. |
| PubMedID- 24219484 | Although there is a high uptake of vaccinations providing protection against bordetella pertussis, the main cause of whooping cough, there has been an increase in the incidence of notifications of the disease in the uk and other developed countries in recent years. |
| PubMedID- 22940441 | Bordetella pertussis, the cause of whooping cough, is highly contagious. |
| PubMedID- 23092514 | Licensed in the mid-1940s, the first whooping cough vaccines consisted of whole-cell inactivated b. pertussis (wp), and their use led to a dramatic decrease in disease incidence by the mid-1960s (2,3). |
| PubMedID- 26129684 | pertussisproteingeneb-cell epitopechildren with whooping coughpertussis toxin subunit 4 precursorptxs4cfgkdlkrpgsspmep.69a protein (pertactin)prnlwyaesnalskrlgep.69a protein (pertactin)prnavvhlqlatirrgdafilamentous hemagglutininfhabfaadlrtvyakqadqbifunctional hemolysin-adenylate cyclaseprecursorcyaahaanqavdqagieklouter membrane porin protein precursoromppfgvntfadgfkansychildren who received the the dtpa2 vaccinebifunctional hemolysin-adenylate cyclaseprecursorcyaadqtvsgleigldrgvtracheal colonization factortcfaasnglrikddgtnsmthe table shows the sequence of target epitopes specifically recognized in serum (10/10) children with whooping cough (n = 6 peptides) and in serum from children who receivedthe diphtheria, tetanus, pertussis acellular 2 components (dtpa2) vaccine (2 peptides). |
| PubMedID- 21115396 | The occasionally severe neurological complications following the human respiratory tract infection 'whooping cough' have been attributed to pertussis toxin (pt) expressed by the causative agent bordetella pertussis. |
| PubMedID- 24721229 | Infection with b holmesii is frequently misidentified as being with b pertussis, the cause of whooping cough, because routine diagnostic tests for pertussis are not species-specific. |
| PubMedID- PMC4512410 | Bordetella pertussis infection (whooping cough) has been on the riseand the most cases in the us since 1955 were reported in 2012 (48,277 or 15.4 per100,000) [1]. |
| PubMedID- 23249233 | whooping cough, due to bordetella pertussis and bordetella parapertussis, is an important cause of childhood morbidity and mortality. |
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