PedAM
Pediatric Disease Annotations & Medicines
| Disease | pancreatitis |
| Phenotype | C0235974|pancreatic cancer |
| Sentences | 29 |
| PubMedID- 24504548 | Moreover it has been observed that kras point mutations could also occur in chronic pancreatitis and are associated with evolution towards pancreatic cancer [26], [27]. |
| PubMedID- 22406605 | Context: pancreatic cancers can present with pancreatitis or its complications. |
| PubMedID- 26146615 | Screening for pancreatic cancer in patients with hereditary pancreatitis has been recommended to start at age of 40 [18]. |
| PubMedID- 25531501 | The aim of our study was to examine igg4 serum levels and pancreatic tissue with respect to the simultaneous presence of autoimmune pancreatitis in patients with pancreatic cancer. |
| PubMedID- 25982967 | However, questions have been raised over the long-term safety of incretin-based therapies: in particular, an off-target effect on ductal cells of the exocrine pancreas may increase the incidence of pancreatitis, potentially leading to pancreatic cancer [60,61]. |
| PubMedID- 20123159 | Results: after adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [or], 4.68; 95% confidence interval [95% ci], 2.23-9.84). |
| PubMedID- 22536256 | High serum igg4 concentrations have been observed in 90% of patients with autoimmune pancreatitis, but rarely in patients with pancreatic cancer, chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and sjögren's syndrome, suggesting that igg4 is a sensitive and specific marker of autoimmune pancreatitis and may be diagnostic for this disease [5]. |
| PubMedID- 22414467 | Among six genes, p16 was more specifically methylated in pancreatic cancer compared with chronic pancreatitis (p=0.016). |
| PubMedID- 22511932 | Given the fact that not all cases of pancreatic cancer are associated with chronic pancreatitis, it could be that other forms of inflammation have a similar effect. |
| PubMedID- 22989892 | The aim of this study was to confirm the high incidence of pancreatic cancer in patients with chronic pancreatitis in japan and to determine the factors associated with the risk for pancreatic cancer in patients with chronic pancreatitis. |
| PubMedID- 25419353 | For ca 19-9 measurement, its diagnostic value decreased in differentiating pancreatic cancer for patients with pancreatitis, especially chronic process. |
| PubMedID- 21510309 | This study aimed to identify a high risk group for developing pancreatic cancer associated with chronic pancreatitis, particularly the presence of k-ras mutations in the pancreatic juice. |
| PubMedID- 22517654 | pancreatic cancer arising from pancreatitis is thought to occur only after several decades of ongoing recurrent acute attacks of pancreatitis most clearly evident in patients with hereditary forms of the disease (12), much in the way chronic inflammation predisposes to the development of other cancers, and not as a consequence of a short duration of drug-induced pancreatitis. |
| PubMedID- 24708788 | Results: mif expression was significantly increased in pancreatic cancer tissues compared with chronic pancreatitis or normal pancreas specimens. |
| PubMedID- 25887404 | That obstructive pancreatitis complicated with pancreatic cancer also revealed abundant igg4-bearing plasma cell infiltration [43], lpsp with marked igg4-bearing plasma cell infiltration may have coexisted with obstructive pancreatitis. |
| PubMedID- 24228121 | Igg4-related autoimmune pancreatitis with pancreatic cancer has been reported. |
| PubMedID- 24967284 | The diffuse uptake in cases of pancreatic cancer was due to obstructive pancreatitis which could be differentiated by other ct features. |
| PubMedID- 23018013 | The association of chronic pancreatitis with pancreatic cancer requires strict follow-up, especially in patients with inflammatory masses in the context of chronic pancreatitis. |
| PubMedID- 20103562 | Of perhaps greatest concern in the case of the glp-1–based drugs, including glp-1 agonists and dipeptidyl peptidase-4 (dpp-4) inhibitors, is preliminary evidence to suggest the potential risks of asymptomatic chronic pancreatitis and, with time, pancreatic cancer. |
| PubMedID- 20349126 | Alcohol consumption also may lead to asymptomatic chronic pancreatitis that then leads to pancreatic cancer [66–71], although the prevalence of the history of pancreatitis is small in the overall population of pancreatic cancer patients. |
| PubMedID- 22973234 | Of particular relevance in this regard were the known increased risk of pancreatic cancer in patients with chronic pancreatitis (raimondi et al., 2010) and the commonalities in gene expression between the stromal compartments of chronic pancreatitis and pancreatic cancer (binkley et al., 2004). |
| PubMedID- 24660091 | Smoking compounds can worsen chronic pancreatitis leading to pancreatic cancer [53]. |
| PubMedID- 22617158 | Research findings pointing to this direction include the documented relationship of pancreatic cancer risk with chronic pancreatitis (raimondi et al, 2010), as well as with smoking (lynch et al, 2009; vrieling et al, 2010), pre-existing and long-standing diabetes mellitus (huxley et al, 2005), and excess weight (genkinger et al, 2010), all of which are known or suggestive determinants of low-grade inflammatory states (whitcomb, 2004; kolb and mandrup-poulsen, 2005; hotamisligil, 2006; goncalves et al, 2011). |
| PubMedID- 25848351 | A prediction rule was developed to stratify the risk for pancreatic cancer in patients with chronic pancreatitis, where gender, mass location, mass number, direct bilirubin, and ca 19-9 were included in the calculation [10]. |
| PubMedID- 22338093 | The commentary that accompanied the publication of the article suggested a concern that long-term, asymptomatic pancreatitis may lead to pancreatic cancer (31). |
| PubMedID- 25061491 | There is still an increased risk of pancreatic cancer in patients with hereditary pancreatitis, familial atypical multiple-mole melanoma syndrome (fammm syndrome), the von hippel-lindau group and a family history of breast cancer [10]. |
| PubMedID- 21309046 | pancreatic cancer was significantly associated with pancreatitis, primarily among those diagnosed within 2 years (or = 7.16; 95% ci = 2.25-22.78). |
| PubMedID- 21946811 | More than 9-times increased risk for pancreatic cancer among patients with acute pancreatitis in chinese population. |
| PubMedID- 19844672 | We affirm that exocrine ductal replication is increased in pancreas obtained from individuals with pancreatitis associated with pancreatic cancer, and to an even greater extent in malignantly transformed ductal cells (fig. |
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