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PedAM

Pediatric Disease Annotations & Medicines




Disease pancreatitis
Phenotype C0010674|cystic fibrosis
Sentences 10
PubMedID- 22410943 Genetic alterations in cftr can be found in patients suffering from chronic pancreatitis and in patients with cystic fibrosis.
PubMedID- 26282838 The unique aspects of the case are highlighted, including the particular risk of drug-associated pancreatitis in those with cystic fibrosis.
PubMedID- 20923678 We investigated whether cftr genotypes determine the risk of pancreatitis in patients with cystic fibrosis (cf).
PubMedID- 22094894 Genetic pancreatitis (gp) is associated with mutations of cystic fibrosis transmembrane conductor regulator gene (cftr), cationic trypsinogen (prss1) gene, and serine protease inhibitor kazal type 1 (spink1).
PubMedID- 20718961 Acute pancreatitis in cystic fibrosis occurs almost exclusively in young patients with pancreatic sufficiency [1].
PubMedID- 24178571 The nonneoplastic diseases of the human pancreas generally comprise the inflammatory and degenerative conditions that include acute and chronic pancreatitis, with cystic fibrosis being arguably one of the most important diseases that induce the condition.
PubMedID- 20977904 Combined bicarbonate conductance-impairing variants in cftr and spink1 variants are associated with chronic pancreatitis in patients without cystic fibrosis.
PubMedID- 22515107 In cystic fibrosis and certain cases of chronic pancreatitis, the pancreatic duct epithelium secretes a small amount of fluid with neutral-acidic ph, which causes an obstruction of the duct lumen by a protein plug or viscous mucus.
PubMedID- 23469112 Provided that a fast protease-substrate is used these results open the door to better diagnoses of a number of important pathologies (cystic fibrosis, inflammation, pancreatitis) by omri or electron paramagnetic resonance imaging in vivo.
PubMedID- 20332619 Notably, cftr mutations not causal for classical cystic fibrosis segregate with unexplained pancreatitis and one of these lies in nbd1 near its atp-clamp (s573c; close to the walker b aspartate d572).

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