PedAM
Pediatric Disease Annotations & Medicines
| Disease | pancreatic cancer |
| Phenotype | C0030305|pancreatitis |
| Sentences | 43 |
| PubMedID- 24660091 | Smoking compounds can worsen chronic pancreatitis leading to pancreatic cancer [53]. |
| PubMedID- 24091659 | A history of alcoholism was known in five of these patients, one case represented an obstructive pancreatitis due to impn-related pancreatic cancer, and in one patient the cp was idiopathic. |
| PubMedID- 21510309 | This study aimed to identify a high risk group for developing pancreatic cancer associated with chronic pancreatitis, particularly the presence of k-ras mutations in the pancreatic juice. |
| PubMedID- 20123159 | Results: after adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [or], 4.68; 95% confidence interval [95% ci], 2.23-9.84). |
| PubMedID- 22338093 | The commentary that accompanied the publication of the article suggested a concern that long-term, asymptomatic pancreatitis may lead to pancreatic cancer (31). |
| PubMedID- 22511932 | Given the fact that not all cases of pancreatic cancer are associated with chronic pancreatitis, it could be that other forms of inflammation have a similar effect. |
| PubMedID- 21309046 | pancreatic cancer was significantly associated with pancreatitis, primarily among those diagnosed within 2 years (or = 7.16; 95% ci = 2.25-22.78). |
| PubMedID- 26146615 | Screening for pancreatic cancer in patients with hereditary pancreatitis has been recommended to start at age of 40 [18]. |
| PubMedID- 24178755 | However, concerning that diabetes mellitus or chronic pancreatitis might be consequences of pancreatic cancer, we ignored diabetes mellitus or chronic pancreatitis diagnoses within 5 years before pancreatic cancer diagnosis. |
| PubMedID- 24474940 | Reported a 2-fold increased risk of developing pancreatic cancer in smokers with hereditary pancreatitis as compared to non-smokers. |
| PubMedID- 21946811 | More than 9-times increased risk for pancreatic cancer among patients with acute pancreatitis in chinese population. |
| PubMedID- 24212624 | The risk of developing pancreatic cancer for patients with hereditary pancreatitis is much higher than for patients with sporadic chronic pancreatitis [43-45]. |
| PubMedID- 22973234 | Of particular relevance in this regard were the known increased risk of pancreatic cancer in patients with chronic pancreatitis (raimondi et al., 2010) and the commonalities in gene expression between the stromal compartments of chronic pancreatitis and pancreatic cancer (binkley et al., 2004). |
| PubMedID- 24138811 | Several studies have been conducted to clarify the relationship between dm 2, chronic pancreatitis and the risk of developing pancreatic cancer. |
| PubMedID- 22517654 | pancreatic cancer arising from pancreatitis is thought to occur only after several decades of ongoing recurrent acute attacks of pancreatitis most clearly evident in patients with hereditary forms of the disease (12), much in the way chronic inflammation predisposes to the development of other cancers, and not as a consequence of a short duration of drug-induced pancreatitis. |
| PubMedID- 22022519 | More recently, erkan et al [37] used transcript profiling to identify markers to differentiate pasc’s associated with chronic pancreatitis versus those of pancreatic cancer, with the aim of subtyping pasc's into either inflammation or cancer-associated. |
| PubMedID- 25789097 | Chronic pancreatitis increases the risk of developing pancreatic cancer. |
| PubMedID- 22989892 | The aim of this study was to confirm the high incidence of pancreatic cancer in patients with chronic pancreatitis in japan and to determine the factors associated with the risk for pancreatic cancer in patients with chronic pancreatitis. |
| PubMedID- 26266422 | Pc risk is associated with westernized diet, tobacco, alcohol, obesity, chronic pancreatitis, and family history of pancreatic cancer. |
| PubMedID- 23401773 | Data were confirmed by high-density protein microarray in a large cohort of 140 patients affected by pancreatic cancer, 10 patients with chronic pancreatitis and 87 healthy controls. |
| PubMedID- 23531764 | (2010) used transcript profiling to identify markers to differentiate psc associated with chronic pancreatitis against those of pancreatic cancer, with the ultimate aim of subtyping psc into either inflammation- or tumor-associated-psc. |
| PubMedID- 22536256 | High serum igg4 concentrations have been observed in 90% of patients with autoimmune pancreatitis, but rarely in patients with pancreatic cancer, chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and sjögren's syndrome, suggesting that igg4 is a sensitive and specific marker of autoimmune pancreatitis and may be diagnostic for this disease [5]. |
| PubMedID- 25848351 | A prediction rule was developed to stratify the risk for pancreatic cancer in patients with chronic pancreatitis, where gender, mass location, mass number, direct bilirubin, and ca 19-9 were included in the calculation [10]. |
| PubMedID- 24708788 | Mif expression was significantly increased in pancreatic cancer tissues compared with chronic pancreatitis or normal pancreas specimens. |
| PubMedID- 25982967 | However, questions have been raised over the long-term safety of incretin-based therapies: in particular, an off-target effect on ductal cells of the exocrine pancreas may increase the incidence of pancreatitis, potentially leading to pancreatic cancer [60,61]. |
| PubMedID- 25061491 | There is still an increased risk of pancreatic cancer in patients with hereditary pancreatitis, familial atypical multiple-mole melanoma syndrome (fammm syndrome), the von hippel-lindau group and a family history of breast cancer [10]. |
| PubMedID- 22520674 | Risk factors examined included: age, body mass index, smoking status, alcohol, deprivation, diabetes, pancreatitis, previous diagnosis of cancer apart from pancreatic cancer, dysphagia, abdominal pain, abdominal distension, appetite loss, weight loss, diarrhoea, constipation, tiredness, itching, and anaemia. |
| PubMedID- 23053420 | Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study. |
| PubMedID- 24228121 | Igg4-related autoimmune pancreatitis with pancreatic cancer has been reported. |
| PubMedID- 22617158 | Research findings pointing to this direction include the documented relationship of pancreatic cancer risk with chronic pancreatitis (raimondi et al, 2010), as well as with smoking (lynch et al, 2009; vrieling et al, 2010), pre-existing and long-standing diabetes mellitus (huxley et al, 2005), and excess weight (genkinger et al, 2010), all of which are known or suggestive determinants of low-grade inflammatory states (whitcomb, 2004; kolb and mandrup-poulsen, 2005; hotamisligil, 2006; goncalves et al, 2011). |
| PubMedID- 20349126 | Alcohol consumption also may lead to asymptomatic chronic pancreatitis that then leads to pancreatic cancer [66–71], although the prevalence of the history of pancreatitis is small in the overall population of pancreatic cancer patients. |
| PubMedID- 25531501 | The aim of our study was to examine igg4 serum levels and pancreatic tissue with respect to the simultaneous presence of autoimmune pancreatitis in patients with pancreatic cancer. |
| PubMedID- 22406605 | Context: pancreatic cancers can present with pancreatitis or its complications. |
| PubMedID- 24574842 | Furthermore, the fact that pancreatic cancer can coexist with complicated pancreatitis should be taken into consideration. |
| PubMedID- 23060806 | Using retrospective, histological examination of pancreases resected on suspicion of pancreatic cancer from patients with mass-forming chronic pancreatitis, american and european pathologists have described another unique histological pattern, called idiopathic duct-centric pancreatitis (idcp) (notohara et al., 2003), or aip with granulocytic epithelial lesion (gel) (zamboni et al., 2004). |
| PubMedID- 19844672 | We affirm that exocrine ductal replication is increased in pancreas obtained from individuals with pancreatitis associated with pancreatic cancer, and to an even greater extent in malignantly transformed ductal cells (fig. |
| PubMedID- 25887404 | That obstructive pancreatitis complicated with pancreatic cancer also revealed abundant igg4-bearing plasma cell infiltration [43], lpsp with marked igg4-bearing plasma cell infiltration may have coexisted with obstructive pancreatitis. |
| PubMedID- 20103562 | Of perhaps greatest concern in the case of the glp-1–based drugs, including glp-1 agonists and dipeptidyl peptidase-4 (dpp-4) inhibitors, is preliminary evidence to suggest the potential risks of asymptomatic chronic pancreatitis and, with time, pancreatic cancer. |
| PubMedID- 22414467 | Among six genes, p16 was more specifically methylated in pancreatic cancer compared with chronic pancreatitis (p=0.016). |
| PubMedID- 25419353 | For ca 19-9 measurement, its diagnostic value decreased in differentiating pancreatic cancer for patients with pancreatitis, especially chronic process. |
| PubMedID- 23018013 | The association of chronic pancreatitis with pancreatic cancer requires strict follow-up, especially in patients with inflammatory masses in the context of chronic pancreatitis. |
| PubMedID- 23678345 | We collected highly standardized samples of pancreatic cancer patients, subjects with pancreatitis, and healthy controls. |
| PubMedID- 18987909 | The risk of developing pancreatic cancer for patients with hereditary pancreatitis (hp) is extremely high [26]. |
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